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Adjustment of Protein Crystal Porosity for Biotemplating: Chemical and Protein Engineering Tools
Protein crystals, routinely prepared for the elucidation of protein 3D structures by X‐ray crystallography, present an ordered and highly accurate 3D array of protein molecules. Inherent to the 3D arrangement of the protein molecules in the crystal is a complementary 3D array of voids made of interconnected cavities and exhibiting highly ordered porosity. Here we propose and demonstrate feasibility of using chemical and genetic tools to alter protein crystal packing by a series of modifications of targeted sites on protein’s surface, enabling the generation of a series of protein crystal biotemplates, all originating from same parent protein.
Adjustment of Protein Crystal Porosity for Biotemplating: Chemical and Protein Engineering Tools
Protein crystals, routinely prepared for the elucidation of protein 3D structures by X‐ray crystallography, present an ordered and highly accurate 3D array of protein molecules. Inherent to the 3D arrangement of the protein molecules in the crystal is a complementary 3D array of voids made of interconnected cavities and exhibiting highly ordered porosity. Here we propose and demonstrate feasibility of using chemical and genetic tools to alter protein crystal packing by a series of modifications of targeted sites on protein’s surface, enabling the generation of a series of protein crystal biotemplates, all originating from same parent protein.
Adjustment of Protein Crystal Porosity for Biotemplating: Chemical and Protein Engineering Tools
Wine, Yariv (Autor:in) / Cohen‐Hadar, Noa (Autor:in) / Lagziel‐Simis, Shira (Autor:in) / Dror, Yael (Autor:in) / Frolow, Felix (Autor:in) / Freeman, Amihay (Autor:in) / Vafai, Kambiz (Herausgeber:in)
POROUS MEDIA AND ITS APPLICATIONS IN SCIENCE, ENGINEERING, AND INDUSTRY: 3rd International Conference ; 2010 ; Montecatini (Italy)
AIP Conference Proceedings ; 1254 ; 198-203
30.05.2010
6 pages
Aufsatz (Konferenz)
Elektronische Ressource
Englisch
Adjustment of Protein Crystal Porosity for Biotemplating: Chemical and Protein Engineering Tools
| British Library Conference Proceedings | 2010
Biomimetics and Biotemplating of Natural Materials
| British Library Online Contents | 2010
| Wiley | 2023
| Wiley | 2023