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Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Enhanced Poromechanical Properties of Tissue Engineered Cartilage via Swelling Induced Collagen Remodelling
Mechanical loading and changes in culture media are both applied in bioreactors to improve the functionality of engineered cartilage tissue. The mechanical properties of articular cartilage are in part determined by its collagen architecture. It was previously shown that mechanical loading can alter structural characteristics of the collagen network. In this study, the influence of culture medium osmolarity and proteoglycan depletion on the collagen network in free swelling hydrogels was investigated with a remodelling algorithm. The driving force for remodelling was the balance between osmotic swelling pressures and tensile stresses in the collagen network as well as the hydrogel scaffold. A finite deformation biphasic model was used to describe the hydrogel and the tissue engineered cartilage. It was demonstrated that proteoglycan digestion at discrete time points during culture and culture in a hypertonic medium can improve the functionality of the collagen network. The positive changes manifested themselves as elevated stiffness values, lower permeabilities and an overall more compact tissue.
Enhanced Poromechanical Properties of Tissue Engineered Cartilage via Swelling Induced Collagen Remodelling
Mechanical loading and changes in culture media are both applied in bioreactors to improve the functionality of engineered cartilage tissue. The mechanical properties of articular cartilage are in part determined by its collagen architecture. It was previously shown that mechanical loading can alter structural characteristics of the collagen network. In this study, the influence of culture medium osmolarity and proteoglycan depletion on the collagen network in free swelling hydrogels was investigated with a remodelling algorithm. The driving force for remodelling was the balance between osmotic swelling pressures and tensile stresses in the collagen network as well as the hydrogel scaffold. A finite deformation biphasic model was used to describe the hydrogel and the tissue engineered cartilage. It was demonstrated that proteoglycan digestion at discrete time points during culture and culture in a hypertonic medium can improve the functionality of the collagen network. The positive changes manifested themselves as elevated stiffness values, lower permeabilities and an overall more compact tissue.
Enhanced Poromechanical Properties of Tissue Engineered Cartilage via Swelling Induced Collagen Remodelling
Nagel, Thomas (Autor:in) / Kolditz, Olaf (Autor:in) / Kelly, Daniel J. (Autor:in)
Fifth Biot Conference on Poromechanics ; 2013 ; Vienna, Austria
Poromechanics V ; 2158-2165
18.06.2013
Aufsatz (Konferenz)
Elektronische Ressource
Englisch
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