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Assessment of Cancellous Bone Microarchitecture from Poroelastic Ultrasound (PEUS) Theory
Propagation of two waves (fast and slow) in trabecular bone has been reported by several laboratories around the world. This is an unequivocal signature of poroelastic wave propagation accordingly to Biot's theory. Velocity and attenuation of fast and slow waves in Biot's poroelasticity theory depend on the porosity, physical properties of the solid and fluid constituents of the porous medium, and the frequency of the wave. Importantly, ultrasound is sensitive to the directionality of pore microarchitecture, which was not taken into account until recently, when a fabric-dependent anisotropic poroelastic wave propagation theory was developed for pure wave modes propagating along a plane of symmetry in an anisotropic medium (Cowin and Cardoso 2011). Key to this development was the addition of the fabric tensor (a quantitative stereological measure of the degree of structural anisotropy of bone) into the linear poroelasticity theory. This framework was further extended to the propagation of quasi-wave modes along an arbitrary direction in porous media (Cardoso and Cowin 2011). In the present study we use this poroelastic ultrasound (PEUS) model of wave propagation to predict the porosity and fabric microarchitecture from measurements of ultrasound wave velocities. Predicted values of microarchitecture are compared to microCT measurements of microarchitecture in the human calcaneum. We have found that the porosity and fabric components of bone microarchitecture derived from PEUS approach are highly correlated to microCT measurements of the same parameters. Therefore, the anisotropic poroelastic ultrasound wave propagation model developed by Cowin and Cardoso (2011) has the potential to assess porosity and microarchitecture directionality which cannot be assessed by DEXA, thus representing a bone quality assessment beyond BMD.
Assessment of Cancellous Bone Microarchitecture from Poroelastic Ultrasound (PEUS) Theory
Propagation of two waves (fast and slow) in trabecular bone has been reported by several laboratories around the world. This is an unequivocal signature of poroelastic wave propagation accordingly to Biot's theory. Velocity and attenuation of fast and slow waves in Biot's poroelasticity theory depend on the porosity, physical properties of the solid and fluid constituents of the porous medium, and the frequency of the wave. Importantly, ultrasound is sensitive to the directionality of pore microarchitecture, which was not taken into account until recently, when a fabric-dependent anisotropic poroelastic wave propagation theory was developed for pure wave modes propagating along a plane of symmetry in an anisotropic medium (Cowin and Cardoso 2011). Key to this development was the addition of the fabric tensor (a quantitative stereological measure of the degree of structural anisotropy of bone) into the linear poroelasticity theory. This framework was further extended to the propagation of quasi-wave modes along an arbitrary direction in porous media (Cardoso and Cowin 2011). In the present study we use this poroelastic ultrasound (PEUS) model of wave propagation to predict the porosity and fabric microarchitecture from measurements of ultrasound wave velocities. Predicted values of microarchitecture are compared to microCT measurements of microarchitecture in the human calcaneum. We have found that the porosity and fabric components of bone microarchitecture derived from PEUS approach are highly correlated to microCT measurements of the same parameters. Therefore, the anisotropic poroelastic ultrasound wave propagation model developed by Cowin and Cardoso (2011) has the potential to assess porosity and microarchitecture directionality which cannot be assessed by DEXA, thus representing a bone quality assessment beyond BMD.
Assessment of Cancellous Bone Microarchitecture from Poroelastic Ultrasound (PEUS) Theory
Cardoso, Luis (Autor:in) / Cowin, Stephen C. (Autor:in)
Fifth Biot Conference on Poromechanics ; 2013 ; Vienna, Austria
Poromechanics V ; 1183-1192
18.06.2013
Aufsatz (Konferenz)
Elektronische Ressource
Englisch
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