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Modeling the Oral Cavity with Mucoadhesive Drug Delivery Systems - A Potential Alternative to Conventional Therapy
Oral mucosal drug delivery system is widely applicable as novel site for administration of drug and controlled release action by preventing first pass metabolism and enzymatic degradation due to GI microbial flora. The oral cavity represents a challenging area to develop an effective drug delivery modelling. This arises due to the various inherent functions of the oral cavity (eating, swallowing, speaking, chewing), as well as the presence of the fluid that is involved in all these activities, saliva. This fluid is continually secreted into and then removed from the mouth. Oral Mucosa drug delivery system provides local and systemic action. The delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety of pharmaceutical compounds via the buccal route. To outline the progress in the in vitro and in vivo modeling of Mucosal drug delivery and provide a critical review of currently used methods. The purpose of this review is to represent the modeling of oral cavity with Mucoadhesive drug delivery systems and clarify the potential alternative to conventional therapy.
Modeling the Oral Cavity with Mucoadhesive Drug Delivery Systems - A Potential Alternative to Conventional Therapy
Oral mucosal drug delivery system is widely applicable as novel site for administration of drug and controlled release action by preventing first pass metabolism and enzymatic degradation due to GI microbial flora. The oral cavity represents a challenging area to develop an effective drug delivery modelling. This arises due to the various inherent functions of the oral cavity (eating, swallowing, speaking, chewing), as well as the presence of the fluid that is involved in all these activities, saliva. This fluid is continually secreted into and then removed from the mouth. Oral Mucosa drug delivery system provides local and systemic action. The delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety of pharmaceutical compounds via the buccal route. To outline the progress in the in vitro and in vivo modeling of Mucosal drug delivery and provide a critical review of currently used methods. The purpose of this review is to represent the modeling of oral cavity with Mucoadhesive drug delivery systems and clarify the potential alternative to conventional therapy.
Modeling the Oral Cavity with Mucoadhesive Drug Delivery Systems - A Potential Alternative to Conventional Therapy
Paul, A. Deevan (Autor:in) / Samatha, P. (Autor:in) / Manasa, S. (Autor:in) / Munemma, R. (Autor:in) / Supriya, D. (Autor:in)
20.11.2017
International Journal of Pharmaceutical Sciences and Drug Research; Vol 9, No 06 (2017) ; 0975-248X
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
DDC:
690
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