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Behaviorally conditioned immunosuppression in a model of rheumatoid arthritis in rats: mechanisms and clinical relevance ; Konditionierung von Immunfunktionen im Model der rheumatoiden Arthritis in der Ratte: Mechanismen und klinische Relevanz
Behaviorally conditioning of immune functions is a fascinating paradigm to analyze the functional bi-directional interaction between the brain and the peripheral immune system. In the experimental approaches applied in this thesis, taste-immune conditioning in rats combined the novel taste saccharin (conditioned stimulus/CS) with an injection of the immunosuppressive drug cyclosporine A (CsA; unconditioned stimulus/UCS). The conditioned response was reflected by conditioned taste avoidance (CTA) as well as diminished interleukin (IL)-2 and interferon (IFN)-y cytokine production. In order to analyze the effects of pre-exposure to the CS or UCS, respectively, on this learned immunosuppression, rats were exposed either to the CS (saccharin) or to the UCS (CsA) prior to conditioning. Pre-exposure to either CS or UCS resulted in an accelerated extinction of the conditioned response on the behavioral level (CTA). In contrast, and more importantly, learned suppression of IL-2 and IFN-y production was not affected. From a clinical perspective, these findings indicate that learned immunosuppression may be inducible in patients that are already on immunosuppressive therapy or have had previous contact to the gustatory stimulus. A second experimental approach focused on the effects of learned immunosuppression on disease development and progression in a rat model of collagen II-induced arthritis. In three experiments, rats were conditioned at various stages of the disease. During retrieval, low-therapeutical doses of the UCS were administered as reminder cues to update and stabilize the memory of the learned immunosuppression. This memory-updating stabilized the learned immune response and significantly suppressed disease progression in immunized rats. Overall, these findings support the notion that associative learning protocols might be employed as supportive therapy to immunopharmacological regimens in patients, with chronic inflammatory autoimmune diseases. ; Die klassische Konditionierung von Immunfunktionen ist ein ...
Behaviorally conditioned immunosuppression in a model of rheumatoid arthritis in rats: mechanisms and clinical relevance ; Konditionierung von Immunfunktionen im Model der rheumatoiden Arthritis in der Ratte: Mechanismen und klinische Relevanz
Behaviorally conditioning of immune functions is a fascinating paradigm to analyze the functional bi-directional interaction between the brain and the peripheral immune system. In the experimental approaches applied in this thesis, taste-immune conditioning in rats combined the novel taste saccharin (conditioned stimulus/CS) with an injection of the immunosuppressive drug cyclosporine A (CsA; unconditioned stimulus/UCS). The conditioned response was reflected by conditioned taste avoidance (CTA) as well as diminished interleukin (IL)-2 and interferon (IFN)-y cytokine production. In order to analyze the effects of pre-exposure to the CS or UCS, respectively, on this learned immunosuppression, rats were exposed either to the CS (saccharin) or to the UCS (CsA) prior to conditioning. Pre-exposure to either CS or UCS resulted in an accelerated extinction of the conditioned response on the behavioral level (CTA). In contrast, and more importantly, learned suppression of IL-2 and IFN-y production was not affected. From a clinical perspective, these findings indicate that learned immunosuppression may be inducible in patients that are already on immunosuppressive therapy or have had previous contact to the gustatory stimulus. A second experimental approach focused on the effects of learned immunosuppression on disease development and progression in a rat model of collagen II-induced arthritis. In three experiments, rats were conditioned at various stages of the disease. During retrieval, low-therapeutical doses of the UCS were administered as reminder cues to update and stabilize the memory of the learned immunosuppression. This memory-updating stabilized the learned immune response and significantly suppressed disease progression in immunized rats. Overall, these findings support the notion that associative learning protocols might be employed as supportive therapy to immunopharmacological regimens in patients, with chronic inflammatory autoimmune diseases. ; Die klassische Konditionierung von Immunfunktionen ist ein ...
Behaviorally conditioned immunosuppression in a model of rheumatoid arthritis in rats: mechanisms and clinical relevance ; Konditionierung von Immunfunktionen im Model der rheumatoiden Arthritis in der Ratte: Mechanismen und klinische Relevanz
Lückemann, Laura (Autor:in) / Schedlowski, Manfred
09.10.2019
Hochschulschrift
Elektronische Ressource
Englisch
Peripheral mediatory mechanisms of behaviorally conditioned immunosuppression by cyclosporin A
| UB Braunschweig | 2008
Online Contents | 1993
ANTI-CYTOKINE THERAPY FOR RHEUMATOID ARTHRITIS
| British Library Online Contents | 2000