Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Torque teno virus load predicts opportunistic Infections after kidney transplantation but Is not associated with maintenance immunosuppression exposure
Measuring the non-pathogenic Torque Teno Virus (TTV) load allows assessing the net immunosuppressive state after kidney transplantation (KTx). Currently, it is not known how exposure to maintenance immunosuppression affects TTV load. We hypothesized that TTV load is associated with the exposure to mycophenolic acid (MPA) and tacrolimus. We performed a prospective study including 54 consecutive KTx. Blood TTV load was measured by an in-house PCR at months 1 and 3. Together with doses and trough blood levels of tacrolimus and MPA, we calculated the coefficient of variability (CV), time in therapeutic range (TTR) and concentration/dose ratio (C/D) of tacrolimus, and the MPA-area under the curve (AUC-MPA) at the third month. TTV load at the first and third month discriminated those patients at risk of developing opportunistic infections between months 1 and 3 (AUC-ROC 0.723, 95%CI 0.559-0.905, p = 0.023) and between months 3 and 6 (AUC-ROC 0.778, 95%CI 0.599-0.957, p = 0.028), respectively, but not those at risk of acute rejection. TTV load did not relate to mean tacrolimus blood level, CV, TTR, C/D and AUC-MPA. To conclude, although TTV is a useful marker of net immunosuppressive status after KTx, it is not related to exposure to maintenance immunosuppression. ; Funding: This research was funded by grants for Fondo de Investigaciones Sanitarias-ISCIII (PI20/01710) and RICORS (ISCIII RD21/0005/0010, “Financiado por la Unión Europea—NextGenerationEU,” Mecanismo para la Recuperación y la Resiliencia [MRR]). Acknowledgments: The authors are indebted to Consuelo Agüeros (Nephrology Research Laboratory, Hospital Marqués de Valdecilla-IDIVAL) for technician support
Torque teno virus load predicts opportunistic Infections after kidney transplantation but Is not associated with maintenance immunosuppression exposure
Measuring the non-pathogenic Torque Teno Virus (TTV) load allows assessing the net immunosuppressive state after kidney transplantation (KTx). Currently, it is not known how exposure to maintenance immunosuppression affects TTV load. We hypothesized that TTV load is associated with the exposure to mycophenolic acid (MPA) and tacrolimus. We performed a prospective study including 54 consecutive KTx. Blood TTV load was measured by an in-house PCR at months 1 and 3. Together with doses and trough blood levels of tacrolimus and MPA, we calculated the coefficient of variability (CV), time in therapeutic range (TTR) and concentration/dose ratio (C/D) of tacrolimus, and the MPA-area under the curve (AUC-MPA) at the third month. TTV load at the first and third month discriminated those patients at risk of developing opportunistic infections between months 1 and 3 (AUC-ROC 0.723, 95%CI 0.559-0.905, p = 0.023) and between months 3 and 6 (AUC-ROC 0.778, 95%CI 0.599-0.957, p = 0.028), respectively, but not those at risk of acute rejection. TTV load did not relate to mean tacrolimus blood level, CV, TTR, C/D and AUC-MPA. To conclude, although TTV is a useful marker of net immunosuppressive status after KTx, it is not related to exposure to maintenance immunosuppression. ; Funding: This research was funded by grants for Fondo de Investigaciones Sanitarias-ISCIII (PI20/01710) and RICORS (ISCIII RD21/0005/0010, “Financiado por la Unión Europea—NextGenerationEU,” Mecanismo para la Recuperación y la Resiliencia [MRR]). Acknowledgments: The authors are indebted to Consuelo Agüeros (Nephrology Research Laboratory, Hospital Marqués de Valdecilla-IDIVAL) for technician support
Torque teno virus load predicts opportunistic Infections after kidney transplantation but Is not associated with maintenance immunosuppression exposure
Cañamero, Lucía (Autor:in) / Benito-Hernández, Adalberto (Autor:in) / González, Elena (Autor:in) / Escagedo, Clara (Autor:in) / Rodríguez-Vidriales, María (Autor:in) / García Saiz, María del Mar (Autor:in) / Valero San Cecilio, Rosalía María (Autor:in) / Belmar Vega, Lara (Autor:in) / Cos Cossio, María de los Ángeles de (Autor:in) / Francia Gil, María Victoria (Autor:in)
01.01.2023
doi:10.3390/biomedicines11051410
Biomedicines, 2023, 11, 1410
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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