Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID):rationale and protocol for a national multicenter observational study in The Netherlands
Background: The coronavirus disease 2019 (COVID-19) pandemic is rapidly expanding across the world, with more than 100,000 new cases each day as of end-June 2020. Healthcare workers are struggling to provide the best care for COVID-19 patients. Approaches for invasive ventilation vary widely between and within countries and new insights are acquired rapidly. We aim to investigate invasive ventilation practices and outcome in COVID-19 patients in the Netherlands. Methods: PRoVENT-COVID ('study of PRactice of VENTilation in COVID-19') is an investigatorinitiated national, multicenter observational study to be undertaken in intensive care units (ICUs) in The Netherlands. Consecutive COVID-19 patients aged 18 years or older, who are receiving invasive ventilation in the participating ICUs, are to be enrolled during a 10-week period, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cmH(2)O) during the first 3 days of ventilation. Secondary outcomes include other ventilatory variables, use of rescue therapies for refractory hypoxemia such as prone positioning and extracorporeal membrane oxygenation, use of sedatives, vasopressors and inotropes; daily cumulative fluid balances; acute kidney injury; ventilator-free days and alive at day 28 (VFD-28), duration of ICU and hospital stay, and ICU, hospital and 90-day mortality. Discussion: PRoVENT-COVID will be the largest observational study to date, with high density ventilatory data and major outcomes. There is urgent need for a better understanding of ventilation practices, and the effects of ventilator settings on outcomes in COVID-19 patients. The results of PRoVENT-COVID will be rapidly disseminated through electronic presentations, such as webinars and electronic conferences, and publications in international peer-reviewed journals. Access to source data will be made available through local, regional and national anonymized ...
PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID):rationale and protocol for a national multicenter observational study in The Netherlands
Background: The coronavirus disease 2019 (COVID-19) pandemic is rapidly expanding across the world, with more than 100,000 new cases each day as of end-June 2020. Healthcare workers are struggling to provide the best care for COVID-19 patients. Approaches for invasive ventilation vary widely between and within countries and new insights are acquired rapidly. We aim to investigate invasive ventilation practices and outcome in COVID-19 patients in the Netherlands. Methods: PRoVENT-COVID ('study of PRactice of VENTilation in COVID-19') is an investigatorinitiated national, multicenter observational study to be undertaken in intensive care units (ICUs) in The Netherlands. Consecutive COVID-19 patients aged 18 years or older, who are receiving invasive ventilation in the participating ICUs, are to be enrolled during a 10-week period, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cmH(2)O) during the first 3 days of ventilation. Secondary outcomes include other ventilatory variables, use of rescue therapies for refractory hypoxemia such as prone positioning and extracorporeal membrane oxygenation, use of sedatives, vasopressors and inotropes; daily cumulative fluid balances; acute kidney injury; ventilator-free days and alive at day 28 (VFD-28), duration of ICU and hospital stay, and ICU, hospital and 90-day mortality. Discussion: PRoVENT-COVID will be the largest observational study to date, with high density ventilatory data and major outcomes. There is urgent need for a better understanding of ventilation practices, and the effects of ventilator settings on outcomes in COVID-19 patients. The results of PRoVENT-COVID will be rapidly disseminated through electronic presentations, such as webinars and electronic conferences, and publications in international peer-reviewed journals. Access to source data will be made available through local, regional and national anonymized ...
PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID):rationale and protocol for a national multicenter observational study in The Netherlands
Boers, Noor S. (Autor:in) / Botta, Michela (Autor:in) / Tsonas, Annisa M. (Autor:in) / Algera, Anna Geke (Autor:in) / Pillay, Janesh (Autor:in) / Dongelmans, Dave A. (Autor:in) / Horn, Janneke (Autor:in) / Vlaar, Alexander P. J. (Autor:in) / Hollmann, Markus W. (Autor:in) / Bos, Lieuwe D. J. (Autor:in)
01.10.2020
PRoVENT-COVID Investigators , Boers , N S , Botta , M , Tsonas , A M , Algera , A G , Pillay , J , Dongelmans , D A , Horn , J , Vlaar , A P J , Hollmann , M W , Bos , L D J , Paulus , F , Serpa Neto , A & Schultz , M J 2020 , ' PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID) : rationale and protocol for a national multicenter observational study in The Netherlands ' , Translational Research , vol. 8 , no. 19 , 1251 . https://doi.org/10.21037/atm-20-5107 ; ISSN:1878-1810
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
DDC:
690