Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Study of the efficacy of a new topical skin formulation rich in antioxidants in patients with mild to moderate atopic dermatitis ; Studie über die Wirksamkeit einer neuen, antioxidantienreichen topischen Hautrezeptur bei Patienten mit leichter bis mittelschwerer Atopic Dermatitis
Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Its pathogenic mechanism is complex, in which oxidative stress plays an important pathogenic role. In the treatment strategy of atopic dermatitis, the role of topical preparations cannot be ignored. As a chronic relapsing inflammatory disease, although topical steroids and immunomodulators can relieve symptoms relatively quickly during the acute period, they cannot be used safely for a long time due to their side effects. Although emollients can be safely used for a long time, they are usually used as an adjuvant therapy, and their independent efficacy studies in vivo are very limited. Given the above information, a topical formulation that is effective in the acute phase and can act as an emollient for long-term use would greatly improve the quality of life of AD patients. Nevertheless, the skin is an organ with barrier properties, and the bio permeable activity of topically applied substances often affects the efficacy of topical formulations. Therefore, to develop a new emollient for long-term use, the work was carried out in three steps: 1. In view of the anti-inflammatory and antioxidant effects of green tea extract, apple extract and curly kale extract reported in related publications, the above extracts were mixed and the anti-inflammatory and skin barrier repairing effects were investigated in vitro, 2. the penetration depth of a formulation containing the extract mixture was investigated on porcine skin ex vivo using Raman microscopy. 3. the effect of the antioxidantrich formulation was investigated in a clinical trial on skin lesions in patients with mild to moderate AD. An in vitro investigation on cells clearly showed the increase in barrier related and anti-inflammatory properties. The antioxidant capacity of the extracts quantified by electron paramagnetic resonance (EPR) spectroscopy, confirmed the strong antioxi-dant effects of the extracts. The penetration results showed that cream containing the extract could penetrate ...
Study of the efficacy of a new topical skin formulation rich in antioxidants in patients with mild to moderate atopic dermatitis ; Studie über die Wirksamkeit einer neuen, antioxidantienreichen topischen Hautrezeptur bei Patienten mit leichter bis mittelschwerer Atopic Dermatitis
Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Its pathogenic mechanism is complex, in which oxidative stress plays an important pathogenic role. In the treatment strategy of atopic dermatitis, the role of topical preparations cannot be ignored. As a chronic relapsing inflammatory disease, although topical steroids and immunomodulators can relieve symptoms relatively quickly during the acute period, they cannot be used safely for a long time due to their side effects. Although emollients can be safely used for a long time, they are usually used as an adjuvant therapy, and their independent efficacy studies in vivo are very limited. Given the above information, a topical formulation that is effective in the acute phase and can act as an emollient for long-term use would greatly improve the quality of life of AD patients. Nevertheless, the skin is an organ with barrier properties, and the bio permeable activity of topically applied substances often affects the efficacy of topical formulations. Therefore, to develop a new emollient for long-term use, the work was carried out in three steps: 1. In view of the anti-inflammatory and antioxidant effects of green tea extract, apple extract and curly kale extract reported in related publications, the above extracts were mixed and the anti-inflammatory and skin barrier repairing effects were investigated in vitro, 2. the penetration depth of a formulation containing the extract mixture was investigated on porcine skin ex vivo using Raman microscopy. 3. the effect of the antioxidantrich formulation was investigated in a clinical trial on skin lesions in patients with mild to moderate AD. An in vitro investigation on cells clearly showed the increase in barrier related and anti-inflammatory properties. The antioxidant capacity of the extracts quantified by electron paramagnetic resonance (EPR) spectroscopy, confirmed the strong antioxi-dant effects of the extracts. The penetration results showed that cream containing the extract could penetrate ...
Study of the efficacy of a new topical skin formulation rich in antioxidants in patients with mild to moderate atopic dermatitis ; Studie über die Wirksamkeit einer neuen, antioxidantienreichen topischen Hautrezeptur bei Patienten mit leichter bis mittelschwerer Atopic Dermatitis
01.01.2024
Hochschulschrift
Elektronische Ressource
Englisch
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