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Iron status is associated with mood, cognition, and functional ability in older adults: a cross-sectional study
Several conditions are risk factors for iron deficiency (ID), some of which are highly prevalent in older individuals. Despite the amount of evidence pointing for a role of ID in cognition, mood and physical functional ability, the research addressing these associations in older individuals is still scarce. In the present study, 162 older community-dwelling individuals (29.53% classified as ID) were enrolled in a cross-sectional analysis and characterized regarding cognition, mood, functional ability, general nutritional intake and iron status. Assessment of iron status was performed using several blood biomarkers. Storage and erythropoiesis dimensions were positively associated with memory, along with an interaction (moderator effect) between iron storage and nutritional status. A more depressed mood was negatively associated with (iron) transport, transport saturation and erythropoiesis dimensions, and functional tiredness was positively associated with the erythropoiesis dimension. These observations indicate that lower iron status is associated with depressive mood, functional tiredness and poorer memory ability, with the latter moderated by nutritional status. These findings suggest that using iron as a continuous variable may be useful in finding associations with iron homeostasis, eventually missed when iron levels are considered within the usual classification groups. ; This work has been funded by National funds, through the Foundation for Science and Technology (FCT)-project UIDB/50026/2020 and UIDP/50026/2020; and by the projects NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), by the Fundacao Calouste Gulbenkian (Portugal) (contract grant number: P-139977; project "Better Mental Health during Ageing based on Temporal Prediction of Individual Brain Ageing Trajectories (TEMPO)") and by the European Commission (FP7): "SwitchBox" (Contract HEALTH-F2-2010-259772). C.P.-N was supported by the Portuguese Science Foundation (FCT) doctoral scholarship PD/BD/106050/2015 via the Inter-University PhD Programme in Ageing and Chronic Diseases, T.C.C. was a recipient of a doctoral fellowship from the Portuguese Foundation for Science and Technology (FCT; SFRH/BD/90078/2012), L.A. was a recipient of a doctoral fellowship from the Portuguese Foundation for Science and Technology (FCT; SFRH/BD/101398/2014), P.S.M. was supported by the FCT fellowship grant with the reference PDE/BDE/113601/2015 from the PhDiHES program, N.C.S. was a recipient of a research assistantship by the through the FCT Investigator Programme 200 infinity Ciencia.
Iron status is associated with mood, cognition, and functional ability in older adults: a cross-sectional study
Several conditions are risk factors for iron deficiency (ID), some of which are highly prevalent in older individuals. Despite the amount of evidence pointing for a role of ID in cognition, mood and physical functional ability, the research addressing these associations in older individuals is still scarce. In the present study, 162 older community-dwelling individuals (29.53% classified as ID) were enrolled in a cross-sectional analysis and characterized regarding cognition, mood, functional ability, general nutritional intake and iron status. Assessment of iron status was performed using several blood biomarkers. Storage and erythropoiesis dimensions were positively associated with memory, along with an interaction (moderator effect) between iron storage and nutritional status. A more depressed mood was negatively associated with (iron) transport, transport saturation and erythropoiesis dimensions, and functional tiredness was positively associated with the erythropoiesis dimension. These observations indicate that lower iron status is associated with depressive mood, functional tiredness and poorer memory ability, with the latter moderated by nutritional status. These findings suggest that using iron as a continuous variable may be useful in finding associations with iron homeostasis, eventually missed when iron levels are considered within the usual classification groups. ; This work has been funded by National funds, through the Foundation for Science and Technology (FCT)-project UIDB/50026/2020 and UIDP/50026/2020; and by the projects NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), by the Fundacao Calouste Gulbenkian (Portugal) (contract grant number: P-139977; project "Better Mental Health during Ageing based on Temporal Prediction of Individual Brain Ageing Trajectories (TEMPO)") and by the European Commission (FP7): "SwitchBox" (Contract HEALTH-F2-2010-259772). C.P.-N was supported by the Portuguese Science Foundation (FCT) doctoral scholarship PD/BD/106050/2015 via the Inter-University PhD Programme in Ageing and Chronic Diseases, T.C.C. was a recipient of a doctoral fellowship from the Portuguese Foundation for Science and Technology (FCT; SFRH/BD/90078/2012), L.A. was a recipient of a doctoral fellowship from the Portuguese Foundation for Science and Technology (FCT; SFRH/BD/101398/2014), P.S.M. was supported by the FCT fellowship grant with the reference PDE/BDE/113601/2015 from the PhDiHES program, N.C.S. was a recipient of a research assistantship by the through the FCT Investigator Programme 200 infinity Ciencia.
Iron status is associated with mood, cognition, and functional ability in older adults: a cross-sectional study
Portugal-Nunes, Carlos (Autor:in) / Castanho, Teresa Costa (Autor:in) / Amorim, Liliana (Autor:in) / Moreira, Pedro Silva (Autor:in) / Mariz, José (Autor:in) / Marques, Fernanda (Autor:in) / Sousa, Nuno (Autor:in) / Santos, Nadine Correia (Autor:in) / Palha, Joana Almeida (Autor:in)
01.01.2020
33238615
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
DDC:
690
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