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pH-Responsive Polymersome Microparticles as Smart Cyclodextrin-Releasing Agents
Bayir, Ece/0000-0003-4886-3860; Puglisi, Antonino/0000-0001-8998-0700 ; WOS: 000490658900037 ; PubMed: 31553586 ; Cyclodextrins (CDs) are increasingly drawing attention as potential therapeutic tools in the treatment of cholesterol-associated diseases. However, bioavailability and delivery of CDs in the monomeric form still remain challenging. CD-based macromolecular systems seem to display a promising capacity in overcoming some of these limitations. Therefore, smart, stimuli-responsive nanosystems are currently being investigated in order to provide improved CD-releasing agents. Herein, we present a novel class of CD based polymersome microparticles (CD-PMs) designed for potential therapeutic use. A new synthetic route to obtain a CD-appended, pH-sensitive polymer that self-assembles into a stable polymersome microparticle is reported. Through an easy-to-use approach, a benzoic imine bond is incorporated into a poly(e-caprolactone) backbone and employed as a building block in the construction of the nanoarchitecture. the CD-PMs show cellular uptake representing a promising potential therapeutic tool in the treatment of cholesterol-associated conditions such as neurodegenerative diseases. ; European UnionEuropean Union (EU) [786560] ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 786560. SEM and cell culture experiments were performed at EGE MATAL (Ege University/Izmir).
pH-Responsive Polymersome Microparticles as Smart Cyclodextrin-Releasing Agents
Bayir, Ece/0000-0003-4886-3860; Puglisi, Antonino/0000-0001-8998-0700 ; WOS: 000490658900037 ; PubMed: 31553586 ; Cyclodextrins (CDs) are increasingly drawing attention as potential therapeutic tools in the treatment of cholesterol-associated diseases. However, bioavailability and delivery of CDs in the monomeric form still remain challenging. CD-based macromolecular systems seem to display a promising capacity in overcoming some of these limitations. Therefore, smart, stimuli-responsive nanosystems are currently being investigated in order to provide improved CD-releasing agents. Herein, we present a novel class of CD based polymersome microparticles (CD-PMs) designed for potential therapeutic use. A new synthetic route to obtain a CD-appended, pH-sensitive polymer that self-assembles into a stable polymersome microparticle is reported. Through an easy-to-use approach, a benzoic imine bond is incorporated into a poly(e-caprolactone) backbone and employed as a building block in the construction of the nanoarchitecture. the CD-PMs show cellular uptake representing a promising potential therapeutic tool in the treatment of cholesterol-associated conditions such as neurodegenerative diseases. ; European UnionEuropean Union (EU) [786560] ; This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 786560. SEM and cell culture experiments were performed at EGE MATAL (Ege University/Izmir).
pH-Responsive Polymersome Microparticles as Smart Cyclodextrin-Releasing Agents
Puglisi, Antonino (Autor:in) / Bayir, Ece (Autor:in) / Timur, Suna (Autor:in) / Yagci, Yusuf (Autor:in) / Ege Üniversitesi
01.01.2019
4007
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
DDC:
690
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