Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Sled dogs as a model for PM2.5 exposure from wildfires in Alaska
Particulate matter 2.5 (PM2.5) exposure induces oxidative stress associated with many negative health outcomes such as respiratory disorders, cardiovascular disease and neurodegenerative disease. Research shows that diet and exercise can improve antioxidant defense against oxidative stress. This study is the first to use an Arctic animal model to investigate the cumulative effects of two lifestyle interventions on the antioxidant response before, during, and after ambient PM 2.5 exposure from wildfire: antioxidant supplementation (Arthrospira platensis) and exercise. In a two-factorial, longitudinal design, this study divided sled dogs (n = 48) into four groups (exercise and supplemented, exercise, supplemented, and control) to (1) test the effects of a 30-day exercise and antioxidant supplementation protocol on antioxidant response; and (2) measure the antioxidant response of all groups during and after a natural wildfire event. Commercial assays for total antioxidant power (TAP) and the enzymatic antioxidant superoxide dismutase (SOD) were used as markers for antioxidant status and response. During the forest fire, SOD was increased 5- to 10-fold over pre/post-exposure levels in all groups suggesting an endogenous upregulation of defense systems in response to the acute environmental stress. TAP was lower in all groups at peak PM2.5 exposure compared to 48 h after peak exposure in all groups except the exercise alone group which may indicate that exercise offers improved endogenous defense.
Sled dogs as a model for PM2.5 exposure from wildfires in Alaska
Particulate matter 2.5 (PM2.5) exposure induces oxidative stress associated with many negative health outcomes such as respiratory disorders, cardiovascular disease and neurodegenerative disease. Research shows that diet and exercise can improve antioxidant defense against oxidative stress. This study is the first to use an Arctic animal model to investigate the cumulative effects of two lifestyle interventions on the antioxidant response before, during, and after ambient PM 2.5 exposure from wildfire: antioxidant supplementation (Arthrospira platensis) and exercise. In a two-factorial, longitudinal design, this study divided sled dogs (n = 48) into four groups (exercise and supplemented, exercise, supplemented, and control) to (1) test the effects of a 30-day exercise and antioxidant supplementation protocol on antioxidant response; and (2) measure the antioxidant response of all groups during and after a natural wildfire event. Commercial assays for total antioxidant power (TAP) and the enzymatic antioxidant superoxide dismutase (SOD) were used as markers for antioxidant status and response. During the forest fire, SOD was increased 5- to 10-fold over pre/post-exposure levels in all groups suggesting an endogenous upregulation of defense systems in response to the acute environmental stress. TAP was lower in all groups at peak PM2.5 exposure compared to 48 h after peak exposure in all groups except the exercise alone group which may indicate that exercise offers improved endogenous defense.
Sled dogs as a model for PM2.5 exposure from wildfires in Alaska
Jacob J. Witkop (Autor:in) / Theresa Vertigan (Autor:in) / Arleigh Reynolds (Autor:in) / Lawrence Duffy (Autor:in) / Bahareh Barati (Autor:in) / Scott Jerome (Autor:in) / Kriya Dunlap (Autor:in)
2021
Aufsatz (Zeitschrift)
Elektronische Ressource
Unbekannt
Metadata by DOAJ is licensed under CC BY-SA 1.0
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