Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics
Plastic pollution has emerged as a critical global environmental challenge, yet the effects of the ingested plastic particles on ocular health remain largely unexplored. In this study, we investigated the impact of orally ingested polystyrene nanoplastics (PS-NPs) on the mouse retina. The in vivo experimental results showed that PS-NPs could penetrate the mouse retina within 2 h after gavage. Their levels increased at 4 h and remained detectable up to 24 h post-gavage. Prolonged exposure (28 days) to PS-NPs might disrupt the tight junctions of the inner blood-retinal barrier (iBRB). Moreover, PS-NPs induced oxidative stress in the retina by downregulating the expression of Nrf2 and HO-1, and potentially promoted apoptosis via the upregulation of Cleaved caspase 3. Additionally, we used human retinal microvascular endothelial cells (HRMECs) to model the iBRB and employed a human retinal pigment epithelial cell line (ARPE-19) to assess the potential toxicity of PS-NPs on the human retina. Our results indicated that PS-NPs penetrated and disrupted the simulated iBRB, inducing oxidative stress and promoting apoptosis in ARPE-19 cells. This study provides critical insights into the potential risks of ingested PS-NPs to retinal health and offers novel perspectives on the broader implications of plastic pollution for humans.
In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics
Plastic pollution has emerged as a critical global environmental challenge, yet the effects of the ingested plastic particles on ocular health remain largely unexplored. In this study, we investigated the impact of orally ingested polystyrene nanoplastics (PS-NPs) on the mouse retina. The in vivo experimental results showed that PS-NPs could penetrate the mouse retina within 2 h after gavage. Their levels increased at 4 h and remained detectable up to 24 h post-gavage. Prolonged exposure (28 days) to PS-NPs might disrupt the tight junctions of the inner blood-retinal barrier (iBRB). Moreover, PS-NPs induced oxidative stress in the retina by downregulating the expression of Nrf2 and HO-1, and potentially promoted apoptosis via the upregulation of Cleaved caspase 3. Additionally, we used human retinal microvascular endothelial cells (HRMECs) to model the iBRB and employed a human retinal pigment epithelial cell line (ARPE-19) to assess the potential toxicity of PS-NPs on the human retina. Our results indicated that PS-NPs penetrated and disrupted the simulated iBRB, inducing oxidative stress and promoting apoptosis in ARPE-19 cells. This study provides critical insights into the potential risks of ingested PS-NPs to retinal health and offers novel perspectives on the broader implications of plastic pollution for humans.
In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics
Jiang Zheng (Autor:in) / Lun He (Autor:in) / Qi Shi (Autor:in) / Meilan Wang (Autor:in) / Yu Ma (Autor:in) / Wenjuan Yu (Autor:in) / Lian Liu (Autor:in) / Guocheng Yu (Autor:in) / Xiaoting Liu (Autor:in) / Boguang Wang (Autor:in)
2025
Aufsatz (Zeitschrift)
Elektronische Ressource
Unbekannt
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Sorption Behavior of Trace Organic Chemicals on Carboxylated Polystyrene Nanoplastics
| American Chemical Society | 2024