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Persistent organic pollutants and diabetes among Inuit in the Canadian Arctic
https://orcid.org/0000-0003-4351-7483
AbstractType 2 diabetes is a chronic metabolic disease that is of increasing concern in Inuit communities. Behavioural factors such as physical inactivity and poor diet are well-known risk factors. Exposure to persistent organic pollutants (POPs) has emerged as an additional factor in the pathogenesis of diabetes.In this study, association between polychlorinated biphenyls (PCBs) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) with diabetes in Canadian Inuit was examined.Data from the Adult Inuit Health Survey (2007–2008) of Inuit participants from the Canadian Arctic were analyzed. Self-reported diabetes (excluding gestational diabetes) and clinical measurement of fasting glucose were examined as outcomes. Association with individual PCB congeners, sum of dioxin-like PCBs (∑DL-PCB), non-dioxin-like PCBs (∑NDL-PCB), total PCBs (∑PCB), and p,p′-DDE were investigated using multiple regression models adjusted for confounding factors. Using different methods to incorporate serum lipids, highest vs. lowest quartile exposures to PCB-105, PCB-118, PCB-153, PCB-156, PCB-170, PCB-180, PCB-183, ∑PCB, and p,p′-DDE were associated with increased risk of diabetes. For these PCBs, odds ratios (ORs) ranged from 1.9–3.5 (lower 95% CI: 0.8–1.4, upper 95% CI: 4.4–9.0) and for p,p′-DDE the OR was 2.5 (lower 95% CI: 1.1–1.2, upper 95% CI: 5.9–6.0). The highest vs. lowest quartile exposure to most PCBs and p,p′-DDE were associated with an increase of fasting glucose by 3–7%.PCBs and p,p′-DDE were associated with increased risk of diabetes and higher fasting glucose level in a cross-sectional survey of Canadian Inuit. Cause-effect relationships of PCBs and p,p′-DDE with diabetes and diabetes-related outcomes need to be further investigated in a cohort study.
HighlightsBlood PCB and p,p′-DDE levels were associated with increased risk of self-reported diabetes among Canadian Inuit.Fasting glucose in the highest quartile of exposure was 3–7% higher compared with the lowest quartile of exposure.Contaminant exposure, as a risk factor for diabetes, needs to be further investigated in cohort studies.
Persistent organic pollutants and diabetes among Inuit in the Canadian Arctic
https://orcid.org/0000-0003-4351-7483
AbstractType 2 diabetes is a chronic metabolic disease that is of increasing concern in Inuit communities. Behavioural factors such as physical inactivity and poor diet are well-known risk factors. Exposure to persistent organic pollutants (POPs) has emerged as an additional factor in the pathogenesis of diabetes.In this study, association between polychlorinated biphenyls (PCBs) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) with diabetes in Canadian Inuit was examined.Data from the Adult Inuit Health Survey (2007–2008) of Inuit participants from the Canadian Arctic were analyzed. Self-reported diabetes (excluding gestational diabetes) and clinical measurement of fasting glucose were examined as outcomes. Association with individual PCB congeners, sum of dioxin-like PCBs (∑DL-PCB), non-dioxin-like PCBs (∑NDL-PCB), total PCBs (∑PCB), and p,p′-DDE were investigated using multiple regression models adjusted for confounding factors. Using different methods to incorporate serum lipids, highest vs. lowest quartile exposures to PCB-105, PCB-118, PCB-153, PCB-156, PCB-170, PCB-180, PCB-183, ∑PCB, and p,p′-DDE were associated with increased risk of diabetes. For these PCBs, odds ratios (ORs) ranged from 1.9–3.5 (lower 95% CI: 0.8–1.4, upper 95% CI: 4.4–9.0) and for p,p′-DDE the OR was 2.5 (lower 95% CI: 1.1–1.2, upper 95% CI: 5.9–6.0). The highest vs. lowest quartile exposure to most PCBs and p,p′-DDE were associated with an increase of fasting glucose by 3–7%.PCBs and p,p′-DDE were associated with increased risk of diabetes and higher fasting glucose level in a cross-sectional survey of Canadian Inuit. Cause-effect relationships of PCBs and p,p′-DDE with diabetes and diabetes-related outcomes need to be further investigated in a cohort study.
HighlightsBlood PCB and p,p′-DDE levels were associated with increased risk of self-reported diabetes among Canadian Inuit.Fasting glucose in the highest quartile of exposure was 3–7% higher compared with the lowest quartile of exposure.Contaminant exposure, as a risk factor for diabetes, needs to be further investigated in cohort studies.
Persistent organic pollutants and diabetes among Inuit in the Canadian Arctic
https://orcid.org/0000-0003-4351-7483
AbstractType 2 diabetes is a chronic metabolic disease that is of increasing concern in Inuit communities. Behavioural factors such as physical inactivity and poor diet are well-known risk factors. Exposure to persistent organic pollutants (POPs) has emerged as an additional factor in the pathogenesis of diabetes.In this study, association between polychlorinated biphenyls (PCBs) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) with diabetes in Canadian Inuit was examined.Data from the Adult Inuit Health Survey (2007–2008) of Inuit participants from the Canadian Arctic were analyzed. Self-reported diabetes (excluding gestational diabetes) and clinical measurement of fasting glucose were examined as outcomes. Association with individual PCB congeners, sum of dioxin-like PCBs (∑DL-PCB), non-dioxin-like PCBs (∑NDL-PCB), total PCBs (∑PCB), and p,p′-DDE were investigated using multiple regression models adjusted for confounding factors. Using different methods to incorporate serum lipids, highest vs. lowest quartile exposures to PCB-105, PCB-118, PCB-153, PCB-156, PCB-170, PCB-180, PCB-183, ∑PCB, and p,p′-DDE were associated with increased risk of diabetes. For these PCBs, odds ratios (ORs) ranged from 1.9–3.5 (lower 95% CI: 0.8–1.4, upper 95% CI: 4.4–9.0) and for p,p′-DDE the OR was 2.5 (lower 95% CI: 1.1–1.2, upper 95% CI: 5.9–6.0). The highest vs. lowest quartile exposure to most PCBs and p,p′-DDE were associated with an increase of fasting glucose by 3–7%.PCBs and p,p′-DDE were associated with increased risk of diabetes and higher fasting glucose level in a cross-sectional survey of Canadian Inuit. Cause-effect relationships of PCBs and p,p′-DDE with diabetes and diabetes-related outcomes need to be further investigated in a cohort study.
HighlightsBlood PCB and p,p′-DDE levels were associated with increased risk of self-reported diabetes among Canadian Inuit.Fasting glucose in the highest quartile of exposure was 3–7% higher compared with the lowest quartile of exposure.Contaminant exposure, as a risk factor for diabetes, needs to be further investigated in cohort studies.
Persistent organic pollutants and diabetes among Inuit in the Canadian Arctic
Singh, Kavita (Autor:in) / Chan, Hing Man (Autor:in)
Environmental International ; 101 ; 183-189
03.02.2017
7 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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