Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Risk assessment and dissemination mechanism of antibiotic resistance genes in compost
https://orcid.org/0009-0005-0939-7969
Graphical abstract Display Omitted
Highlights A comprehensive investigation of antibiotic resistance genes (ARGs) in compost. The potential risk of ARGs in compost lies between manure and soil. The metabolic interactions dominated by antibiotic-resistant bacteria might intensify the transfer of ARGs.
Abstract In recent years, the excessive of antibiotics in livestock and poultry husbandry, stemming from extensive industry experience, has resulted in the accumulation of residual antibiotics and antibiotic resistance genes (ARGs) in livestock manure. Composting, as a crucial approach for the utilization of manure resources, has the potential to reduce the levels of antibiotics and ARGs in manure, although complete elimination is challenging. Previous studies have primarily focused on the diversity and abundance of ARGs in compost or have solely examined the correlation between ARGs and their carriers, potentially leading to a misjudgment of the actual risk associated with ARGs in compost. To address this gap, this study investigated the transfer potential of ARGs in compost and their co-occurrence with opportunistic pathogenic bacteria by extensively analyzing metagenomic sequencing data of compost worldwide. The results demonstrated that the potential risk of ARGs in compost was significantly lower than in manure, suggesting that composting effectively reduces the risk of ARGs. Further analysis showed that the microbes shifted their life history strategy in manure and compost due to antibiotic pressure and formed metabolic interactions dominated by antibiotic-resistant microbes, increasing ARG dissemination frequency. Therefore, husbandry practice without antibiotic addition was recommended to control ARG evolution, dissemination, and abatement both at the source and throughout processing.
Risk assessment and dissemination mechanism of antibiotic resistance genes in compost
https://orcid.org/0009-0005-0939-7969
Graphical abstract Display Omitted
Highlights A comprehensive investigation of antibiotic resistance genes (ARGs) in compost. The potential risk of ARGs in compost lies between manure and soil. The metabolic interactions dominated by antibiotic-resistant bacteria might intensify the transfer of ARGs.
Abstract In recent years, the excessive of antibiotics in livestock and poultry husbandry, stemming from extensive industry experience, has resulted in the accumulation of residual antibiotics and antibiotic resistance genes (ARGs) in livestock manure. Composting, as a crucial approach for the utilization of manure resources, has the potential to reduce the levels of antibiotics and ARGs in manure, although complete elimination is challenging. Previous studies have primarily focused on the diversity and abundance of ARGs in compost or have solely examined the correlation between ARGs and their carriers, potentially leading to a misjudgment of the actual risk associated with ARGs in compost. To address this gap, this study investigated the transfer potential of ARGs in compost and their co-occurrence with opportunistic pathogenic bacteria by extensively analyzing metagenomic sequencing data of compost worldwide. The results demonstrated that the potential risk of ARGs in compost was significantly lower than in manure, suggesting that composting effectively reduces the risk of ARGs. Further analysis showed that the microbes shifted their life history strategy in manure and compost due to antibiotic pressure and formed metabolic interactions dominated by antibiotic-resistant microbes, increasing ARG dissemination frequency. Therefore, husbandry practice without antibiotic addition was recommended to control ARG evolution, dissemination, and abatement both at the source and throughout processing.
Risk assessment and dissemination mechanism of antibiotic resistance genes in compost
https://orcid.org/0009-0005-0939-7969
Graphical abstract Display Omitted
Highlights A comprehensive investigation of antibiotic resistance genes (ARGs) in compost. The potential risk of ARGs in compost lies between manure and soil. The metabolic interactions dominated by antibiotic-resistant bacteria might intensify the transfer of ARGs.
Abstract In recent years, the excessive of antibiotics in livestock and poultry husbandry, stemming from extensive industry experience, has resulted in the accumulation of residual antibiotics and antibiotic resistance genes (ARGs) in livestock manure. Composting, as a crucial approach for the utilization of manure resources, has the potential to reduce the levels of antibiotics and ARGs in manure, although complete elimination is challenging. Previous studies have primarily focused on the diversity and abundance of ARGs in compost or have solely examined the correlation between ARGs and their carriers, potentially leading to a misjudgment of the actual risk associated with ARGs in compost. To address this gap, this study investigated the transfer potential of ARGs in compost and their co-occurrence with opportunistic pathogenic bacteria by extensively analyzing metagenomic sequencing data of compost worldwide. The results demonstrated that the potential risk of ARGs in compost was significantly lower than in manure, suggesting that composting effectively reduces the risk of ARGs. Further analysis showed that the microbes shifted their life history strategy in manure and compost due to antibiotic pressure and formed metabolic interactions dominated by antibiotic-resistant microbes, increasing ARG dissemination frequency. Therefore, husbandry practice without antibiotic addition was recommended to control ARG evolution, dissemination, and abatement both at the source and throughout processing.
Risk assessment and dissemination mechanism of antibiotic resistance genes in compost
Xu, Yifei (Autor:in) / Zhu, Lin (Autor:in) / Chen, Shanguo (Autor:in) / Wu, Haiyan (Autor:in) / Li, Ruiqi (Autor:in) / Li, Jing (Autor:in) / Yuan, Jun (Autor:in) / Wen, Tao (Autor:in) / Xue, Chao (Autor:in) / Shen, Qirong (Autor:in)
30.07.2023
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Compost , Antibiotic resistance genes (ARGs) , Risk assessment , Metagenome , Metabolic interactions , ARGs , antibiotic resistance genes , BMRGs , biocide metal resistance genes , CUB , codon usage bias , MGEs , mobile genetic elements , VFs , virulence factors , MAGs , metagenome-assembled genomes , ARMs , antibiotic-resistant microbes , non-ARMs , nonantibiotic-resistant microbes , HGT , horizontal gene transfer , ICEs , integrative and conjugative elements , MLS , macrolide-lincosamide-streptogramin
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