Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
First trimester plasma PER- AND Polyfluoroalkyl Substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnanacy
https://orcid.org/0000-0002-8835-6997
https://orcid.org/0000-0002-9239-7476
https://orcid.org/0000-0001-6685-0604
https://orcid.org/0000-0001-7752-2585
https://orcid.org/0000-0003-2513-3339
https://orcid.org/0000-0002-5527-5787
https://orcid.org/0000-0002-9796-7482
Graphical abstract Display Omitted
Highlights PFOS was associated with higher parameters of gestational BP trajectories. Positive associations were stronger in participants with parity ≥ 1.
Abstract Background Evidence suggests that exposure to per- and polyfluoroalkyl substances (PFAS) increases risk of high blood pressure (BP) during pregnancy. Prior studies did not examine associations with BP trajectory parameters (i.e., overall magnitude and velocity) during pregnancy, which is linked to adverse pregnancy outcomes. Objectives To estimate associations of multiple plasma PFAS in early pregnancy with BP trajectory parameters across the second and third trimesters. To assess potential effect modification by maternal age and parity. Methods In 1297 individuals, we quantified six PFAS in plasma collected during early pregnancy (median gestational age: 9.4 weeks). We abstracted from medical records systolic BP (SBP) and diastolic BP (DBP) measurements, recorded from 12 weeks gestation until delivery. BP trajectory parameters were estimated via Super Imposition by Translation and Rotation modeling. Subsequently, Bayesian Kernel Machine Regression (BKMR) was employed to estimate individual and joint associations of PFAS concentrations with trajectory parameters – adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index, income, parity, smoking status, and seafood intake. We evaluated effect modification by age at enrollment and parity. Results We collected a median of 13 BP measurements per participant. In BKMR, higher concentration of perfluorooctane sulfonate (PFOS) was independently associated with higher magnitude of overall SBP and DBP trajectories (i.e., upward shift of trajectories) and faster SBP trajectory velocity, holding all other PFAS at their medians. In stratified BKMR analyses, participants with ≥ 1 live birth had more pronounced positive associations between PFOS and SBP velocity, DBP magnitude, and DBP velocity – compared to nulliparous participants. We did not observe significant associations between concentrations of the overall PFAS mixture and either magnitude or velocity of the BP trajectories. Conclusion Early pregnancy plasma PFOS concentrations were associated with altered BP trajectory in pregnancy, which may impact future cardiovascular health of the mother.
First trimester plasma PER- AND Polyfluoroalkyl Substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnanacy
https://orcid.org/0000-0002-8835-6997
https://orcid.org/0000-0002-9239-7476
https://orcid.org/0000-0001-6685-0604
https://orcid.org/0000-0001-7752-2585
https://orcid.org/0000-0003-2513-3339
https://orcid.org/0000-0002-5527-5787
https://orcid.org/0000-0002-9796-7482
Graphical abstract Display Omitted
Highlights PFOS was associated with higher parameters of gestational BP trajectories. Positive associations were stronger in participants with parity ≥ 1.
Abstract Background Evidence suggests that exposure to per- and polyfluoroalkyl substances (PFAS) increases risk of high blood pressure (BP) during pregnancy. Prior studies did not examine associations with BP trajectory parameters (i.e., overall magnitude and velocity) during pregnancy, which is linked to adverse pregnancy outcomes. Objectives To estimate associations of multiple plasma PFAS in early pregnancy with BP trajectory parameters across the second and third trimesters. To assess potential effect modification by maternal age and parity. Methods In 1297 individuals, we quantified six PFAS in plasma collected during early pregnancy (median gestational age: 9.4 weeks). We abstracted from medical records systolic BP (SBP) and diastolic BP (DBP) measurements, recorded from 12 weeks gestation until delivery. BP trajectory parameters were estimated via Super Imposition by Translation and Rotation modeling. Subsequently, Bayesian Kernel Machine Regression (BKMR) was employed to estimate individual and joint associations of PFAS concentrations with trajectory parameters – adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index, income, parity, smoking status, and seafood intake. We evaluated effect modification by age at enrollment and parity. Results We collected a median of 13 BP measurements per participant. In BKMR, higher concentration of perfluorooctane sulfonate (PFOS) was independently associated with higher magnitude of overall SBP and DBP trajectories (i.e., upward shift of trajectories) and faster SBP trajectory velocity, holding all other PFAS at their medians. In stratified BKMR analyses, participants with ≥ 1 live birth had more pronounced positive associations between PFOS and SBP velocity, DBP magnitude, and DBP velocity – compared to nulliparous participants. We did not observe significant associations between concentrations of the overall PFAS mixture and either magnitude or velocity of the BP trajectories. Conclusion Early pregnancy plasma PFOS concentrations were associated with altered BP trajectory in pregnancy, which may impact future cardiovascular health of the mother.
First trimester plasma PER- AND Polyfluoroalkyl Substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnanacy
https://orcid.org/0000-0002-8835-6997
https://orcid.org/0000-0002-9239-7476
https://orcid.org/0000-0001-6685-0604
https://orcid.org/0000-0001-7752-2585
https://orcid.org/0000-0003-2513-3339
https://orcid.org/0000-0002-5527-5787
https://orcid.org/0000-0002-9796-7482
Graphical abstract Display Omitted
Highlights PFOS was associated with higher parameters of gestational BP trajectories. Positive associations were stronger in participants with parity ≥ 1.
Abstract Background Evidence suggests that exposure to per- and polyfluoroalkyl substances (PFAS) increases risk of high blood pressure (BP) during pregnancy. Prior studies did not examine associations with BP trajectory parameters (i.e., overall magnitude and velocity) during pregnancy, which is linked to adverse pregnancy outcomes. Objectives To estimate associations of multiple plasma PFAS in early pregnancy with BP trajectory parameters across the second and third trimesters. To assess potential effect modification by maternal age and parity. Methods In 1297 individuals, we quantified six PFAS in plasma collected during early pregnancy (median gestational age: 9.4 weeks). We abstracted from medical records systolic BP (SBP) and diastolic BP (DBP) measurements, recorded from 12 weeks gestation until delivery. BP trajectory parameters were estimated via Super Imposition by Translation and Rotation modeling. Subsequently, Bayesian Kernel Machine Regression (BKMR) was employed to estimate individual and joint associations of PFAS concentrations with trajectory parameters – adjusting for maternal age, race/ethnicity, pre-pregnancy body mass index, income, parity, smoking status, and seafood intake. We evaluated effect modification by age at enrollment and parity. Results We collected a median of 13 BP measurements per participant. In BKMR, higher concentration of perfluorooctane sulfonate (PFOS) was independently associated with higher magnitude of overall SBP and DBP trajectories (i.e., upward shift of trajectories) and faster SBP trajectory velocity, holding all other PFAS at their medians. In stratified BKMR analyses, participants with ≥ 1 live birth had more pronounced positive associations between PFOS and SBP velocity, DBP magnitude, and DBP velocity – compared to nulliparous participants. We did not observe significant associations between concentrations of the overall PFAS mixture and either magnitude or velocity of the BP trajectories. Conclusion Early pregnancy plasma PFOS concentrations were associated with altered BP trajectory in pregnancy, which may impact future cardiovascular health of the mother.
First trimester plasma PER- AND Polyfluoroalkyl Substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnanacy
Burdeau, Jordan A. (Autor:in) / Stephenson, Briana J.K. (Autor:in) / Aris, Izzuddin M. (Autor:in) / Preston, Emma V. (Autor:in) / Hivert, Marie-France (Autor:in) / Oken, Emily (Autor:in) / Mahalingaiah, Shruthi (Autor:in) / Chavarro, Jorge E. (Autor:in) / Calafat, Antonia M. (Autor:in) / Rifas-Shiman, Sheryl L. (Autor:in)
02.04.2024
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Per- and polyfluoroalkyl substances (PFAS) , Pregnancy , Blood pressure , Hypertensive disorders of pregnancy , BKMR , Bayesian Kernel Machine Regression , BMI , body mass index , BP , blood pressure , CDC , Centers for Disease Control and Prevention , CI , credible interval , DBP , diastolic blood pressure , EtFOSAA , 2-(N-ethyl-perfluorooctane sulfonamido) acetate , FOSA , perfluorooctane sulfonamide , HDP , hypertensive disorders of pregnancy , IQR , interquartile range , kg , kilograms , LOD , limit of detection , m , meters , MeFOSAA , 2-(N-methyl-perfluorooctane sulfonamido) acetate , mL , milliliters , mmHg , millimeters of mercury , ng , nanograms , PFAS , per- and polyfluoroalkyl substances , PFDA , perfluorodecanoate , PFHxS , perfluorohexane sulfonate , PFNA , perfluorononanoate , PFOA , perfluorooctanoate , PFOS , perfluorooctane sulfonate , r<inf>s</inf> , Spearman rank correlation coefficient , SBP , systolic blood pressure , SDs , standard deviations , SE , standard error , SITAR , Super Imposition by Translation and Rotation , U.S. , United States
| DOAJ | 2019
| Elsevier | 2024