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Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues
Abstract Legacy environmental contaminants such as polybrominated diphenyl ethers (PBDEs) are widely detected in human tissues. However, few studies have measured PBDEs in placental tissues, and there are no reported measurements of 2,4,6-tribromophenol (2,4,6-TBP) in placental tissues. Measurements of these contaminants are important for understanding potential fetal exposures, as these compounds have been shown to alter thyroid hormone regulation in vitro and in vivo. In this study, we measured a suite of PBDEs and 2,4,6-TBP in 102 human placental tissues collected between 2010 and 2011 in Durham County, North Carolina, USA. The most abundant PBDE congener detected was BDE-47, with a mean concentration of 5.09ng/g lipid (range: 0.12–141ng/g lipid; detection frequency 91%); however, 2,4,6-TBP was ubiquitously detected and present at higher concentrations with a mean concentration of 15.4ng/g lipid (range:1.31–316ng/g lipid; detection frequency 100%). BDE-209 was also detected in more than 50% of the samples, and was significantly associated with 2,4,6-TBP in placental tissues, suggesting they may have a similar source, or that 2,4,6-TBP may be a degradation product of BDE-209. Interestingly, BDE-209 and 2,4,6-TBP were negatively associated with age (rs =−0.16; p=0.10 and rs =−0.17; p=0.08, respectively). The results of this work indicate that PBDEs and 2,4,6-TBP bioaccumulate in human placenta tissue and likely contribute to prenatal exposures to these environmental contaminants. Future studies are needed to determine if these joint exposures are associated with any adverse health measures in infants and children.
Highlights A suite of PBDEs and 2,4,6-TBP were measured in 102 placenta tissue samples. BDE-209 was detected in more than 50% of the samples. 2,4,6-TBP was found in the highest concentrations in placenta tissue. 2,4,6-TBP was significantly correlated with PBDEs. BDE-209 and 2,4,6-TBP were suggested to be negatively associated with maternal age.
Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues
Abstract Legacy environmental contaminants such as polybrominated diphenyl ethers (PBDEs) are widely detected in human tissues. However, few studies have measured PBDEs in placental tissues, and there are no reported measurements of 2,4,6-tribromophenol (2,4,6-TBP) in placental tissues. Measurements of these contaminants are important for understanding potential fetal exposures, as these compounds have been shown to alter thyroid hormone regulation in vitro and in vivo. In this study, we measured a suite of PBDEs and 2,4,6-TBP in 102 human placental tissues collected between 2010 and 2011 in Durham County, North Carolina, USA. The most abundant PBDE congener detected was BDE-47, with a mean concentration of 5.09ng/g lipid (range: 0.12–141ng/g lipid; detection frequency 91%); however, 2,4,6-TBP was ubiquitously detected and present at higher concentrations with a mean concentration of 15.4ng/g lipid (range:1.31–316ng/g lipid; detection frequency 100%). BDE-209 was also detected in more than 50% of the samples, and was significantly associated with 2,4,6-TBP in placental tissues, suggesting they may have a similar source, or that 2,4,6-TBP may be a degradation product of BDE-209. Interestingly, BDE-209 and 2,4,6-TBP were negatively associated with age (rs =−0.16; p=0.10 and rs =−0.17; p=0.08, respectively). The results of this work indicate that PBDEs and 2,4,6-TBP bioaccumulate in human placenta tissue and likely contribute to prenatal exposures to these environmental contaminants. Future studies are needed to determine if these joint exposures are associated with any adverse health measures in infants and children.
Highlights A suite of PBDEs and 2,4,6-TBP were measured in 102 placenta tissue samples. BDE-209 was detected in more than 50% of the samples. 2,4,6-TBP was found in the highest concentrations in placenta tissue. 2,4,6-TBP was significantly correlated with PBDEs. BDE-209 and 2,4,6-TBP were suggested to be negatively associated with maternal age.
Concentrations of polybrominated diphenyl ethers (PBDEs) and 2,4,6-tribromophenol in human placental tissues
Leonetti, Christopher (Autor:in) / Butt, Craig M. (Autor:in) / Hoffman, Kate (Autor:in) / Miranda, Marie Lynn (Autor:in) / Stapleton, Heather M. (Autor:in)
Environmental International ; 88 ; 23-29
02.12.2015
7 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
2,4,6-TBP , 2,4,6-tribromophenol , BFR , brominated flame retardant , DI , deiodinase , GC/ECNI-MS , electron capture negative ion mass spectrometry , HIPS , high-impact polystyrene , LC–MS/MS , liquid chromatography tandem mass spectrometry , PBDE , polybrominated diphenyl ether , SPE , solid phase extraction , SULT , sulfotransferase , THs , thyroid hormones , TPT , transplacental transfer , TTR , transthyretin , Brominated flame retardants , Polybrominated diphenyl ethers , Thyroid hormone , Placenta
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