Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
The anti-inflammatory activity of natural allophane
Abstract This paper presents evidence of the novel anti-inflammatory properties of natural allophane collected from New Zealand, Japan, and Ecuador. Allophanes were assessed by (i) the mouse-ear edema method using 12-O-tetradecanoylphorbol-13-acetate (TPA) as inflammatory agent; and (ii) the myeloperoxidase (MPO) enzymatic-activity method. After 4h, applying 1mgear−1 allophane conveyed edema inhibition (EI; p ≤0.01) in up to 39%, while MPO content inhibition (CI) values surpassed 60%. Pearson's correlation analysis between EI and MPO data showed that edema was mediated by the migration of neutrophils at t =4h (p <0.05), but not at t =24h. The lack of variation in cellular migration with time was explained because of a reaction of zero-order kinetics. EPR spectra for allophanes showing higher anti-inflammatory activity denoted a broad signal centered at g =2, and an intense spin–spin interaction, typical of a low-spin, octahedral Fe3+ environment (S =1/2); and overlapping signals typical for Ni, with octahedral coordination, explained either by oxidation states +1 (Ni1+), +3 (Ni3+), or bulk Ni2+ ions.
Graphical abstract After 4h, naturally-occurring allophanes (Allo-1, Allo-2, Allo-3, Allo-E), primary components of respirable volcanic ash (<4μm aerodynamic diameter), present novel anti-inflammatory properties, comparable to those by naturally-occurring halloysite (PA, CLA-1) and commercial indomethacin. Display Omitted
Highlights Natural allophane acts as anti-inflammatory. At 4h, applying 1mgear−1 allophane, MPO content inhibition values surpassed 60%. Edema was mediated by the migration of neutrophils at t =4h, but not at t =24h. Highly-active allophane contained octahedral Fe3+ (S =1/2) and Ni (+1, +3, or +2).
The anti-inflammatory activity of natural allophane
Abstract This paper presents evidence of the novel anti-inflammatory properties of natural allophane collected from New Zealand, Japan, and Ecuador. Allophanes were assessed by (i) the mouse-ear edema method using 12-O-tetradecanoylphorbol-13-acetate (TPA) as inflammatory agent; and (ii) the myeloperoxidase (MPO) enzymatic-activity method. After 4h, applying 1mgear−1 allophane conveyed edema inhibition (EI; p ≤0.01) in up to 39%, while MPO content inhibition (CI) values surpassed 60%. Pearson's correlation analysis between EI and MPO data showed that edema was mediated by the migration of neutrophils at t =4h (p <0.05), but not at t =24h. The lack of variation in cellular migration with time was explained because of a reaction of zero-order kinetics. EPR spectra for allophanes showing higher anti-inflammatory activity denoted a broad signal centered at g =2, and an intense spin–spin interaction, typical of a low-spin, octahedral Fe3+ environment (S =1/2); and overlapping signals typical for Ni, with octahedral coordination, explained either by oxidation states +1 (Ni1+), +3 (Ni3+), or bulk Ni2+ ions.
Graphical abstract After 4h, naturally-occurring allophanes (Allo-1, Allo-2, Allo-3, Allo-E), primary components of respirable volcanic ash (<4μm aerodynamic diameter), present novel anti-inflammatory properties, comparable to those by naturally-occurring halloysite (PA, CLA-1) and commercial indomethacin. Display Omitted
Highlights Natural allophane acts as anti-inflammatory. At 4h, applying 1mgear−1 allophane, MPO content inhibition values surpassed 60%. Edema was mediated by the migration of neutrophils at t =4h, but not at t =24h. Highly-active allophane contained octahedral Fe3+ (S =1/2) and Ni (+1, +3, or +2).
The anti-inflammatory activity of natural allophane
Cervini-Silva, Javiera (Autor:in) / Nieto-Camacho, Antonio (Autor:in) / Gómez-Vidales, Virginia (Autor:in) / Kaufhold, Stephan (Autor:in) / Theng, Benny K.G. (Autor:in)
Applied Clay Science ; 105-106 ; 48-51
10.12.2014
4 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Edema inhibition , Neutrophils , Volcanic , Iron , Nickel , Aluminum
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