Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls
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Highlights There is high variability in urinary endocrine-disrupting chemical biomarkers across puberty. Concentration of endocrine disrupting chemical biomarkers decreases with older age. Results suggest windows of susceptibility to phenols, parabens, and phthalates for breast density.
Abstract Background Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis. Methods In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log10-transformed EDCs and log10-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education. Results Urinary EDC biomarker concentrations highly varied across pubertal time points (ICC range 0.01–0.30). For 12 EDCs, biomarker concentrations decreased over time. Triclosan measured at 1-year post-menarche was inversely associated with %FGV at 2-years post-menarche (β = −0.025, 95 % confidence interval = −0.041, −0.008). Mono(2-ethyl-5-carboxypentyl) phthalate and the sum of di(2-ethylhexyl) phthalate metabolite concentrations at B4 were positively associated with aFGV and tBV at 2-years post-menarche. No measured phenols were associated with aFGV and tBV, while no measured parabens were associated with %FGV and aFGV. Conclusions Our study suggests relatively high variability in EDC biomarker concentrations across the peripubertal time period. We also found evidence to suggest that there may be pubertal windows of susceptibility to select EDCs for the association with adolescent breast density.
Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls
Graphical abstract Display Omitted
Highlights There is high variability in urinary endocrine-disrupting chemical biomarkers across puberty. Concentration of endocrine disrupting chemical biomarkers decreases with older age. Results suggest windows of susceptibility to phenols, parabens, and phthalates for breast density.
Abstract Background Epidemiologic evidence suggests that environmental factors acting as endocrine disrupting chemicals (EDCs) are associated with mammographic breast density and the risk of breast cancer. Exposure to EDCs during puberty, a period of rapid breast development, may affect susceptibility to breast carcinogenesis. Methods In a cohort of 366 Chilean adolescents from the Growth and Obesity Cohort Study, we evaluated the relation between urinary concentrations of 15 suspected EDC biomarkers across three pubertal time points (Tanner breast stage 1 (B1), 4 (B4), and 1-year post-menarche) and breast fibroglandular volume (FGV; percent FGV [%FGV] and absolute FGV [aFGV]) and total breast volume (tBV) at 2-years post-menarche. We used linear mixed models to test differences in creatinine-corrected EDC biomarker concentrations at B4 and 1-year post-menarche compared to B1 and calculated intraclass correlation coefficients (ICC) of EDC concentrations across time points to appraise the consistency of measurements. We fit multivariable generalized estimating equations (GEEs) to evaluate windows of susceptibility for the association between log10-transformed EDCs and log10-transformed breast outcomes. GEEs were adjusted for age, body fat percentage, total caloric intake, and maternal education. Results Urinary EDC biomarker concentrations highly varied across pubertal time points (ICC range 0.01–0.30). For 12 EDCs, biomarker concentrations decreased over time. Triclosan measured at 1-year post-menarche was inversely associated with %FGV at 2-years post-menarche (β = −0.025, 95 % confidence interval = −0.041, −0.008). Mono(2-ethyl-5-carboxypentyl) phthalate and the sum of di(2-ethylhexyl) phthalate metabolite concentrations at B4 were positively associated with aFGV and tBV at 2-years post-menarche. No measured phenols were associated with aFGV and tBV, while no measured parabens were associated with %FGV and aFGV. Conclusions Our study suggests relatively high variability in EDC biomarker concentrations across the peripubertal time period. We also found evidence to suggest that there may be pubertal windows of susceptibility to select EDCs for the association with adolescent breast density.
Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls
Yoon, Lara S. (Autor:in) / Binder, Alexandra M. (Autor:in) / Pereira, Ana (Autor:in) / Calafat, Antonia M. (Autor:in) / Shepherd, John (Autor:in) / Corvalán, Camila (Autor:in) / Michels, Karin B. (Autor:in)
14.10.2022
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Endocrine disruptors , Breast density , Puberty , Windows of susceptibility , EDC , Endocrine disrupting chemicals , BPA , Bisphenol A , MEP , Monoethyl phthalate , MEHP , Mono(2-ethylhexyl) phthalate , DEHP , di(2-ethylhexyl) phthalate , BMI , Body mass index , B1 , Tanner breast stage 1 , B4 , Tanner breast stage 4 , MCOP , Monocarboxy-isooctyl phthalate , GOCS , Growth and Obesity Cohort Study , INTA , Instituto de Nutrición y Tecnología de los Alimentos , BPF , Bisphenol F , BPS , Bisphenol S , MECPP , Mono(2-ethyl-5-carboxypentyl) phthalate , MEHHP , Mono(2-ethyl-5-hydroxyhexyl) phthalate , MEOHP , Mono(2-ethyl-5-oxohexyl) phthalate , MiBP , Mono-isobutyl phthalate , MBP , Mono-<italic>n</italic>-butyl phthalate , MCPP , Mono-3-carboxypropyl phthalate , LOD , Limit of detection , MWP , Molecular weight phthalate , DXA , Dual energy X-ray absorptiometry , FGV , Fibroglandular volume , BV , Breast volume , ICC , Intraclass correlation coefficient , LMM , Linear mixed models , GEE , Generalized estimating equation , FDR , False discovery rate , UPF , Ultra-processed foods
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