Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Long-term exposure to ultrafine particles and natural and cause-specific mortality
https://orcid.org/0000-0002-9085-6026
https://orcid.org/0000-0001-9065-6916
https://orcid.org/0000-0003-3612-5780
Abstract Background Health implications of long-term exposure to ubiquitously present ultrafine particles (UFP) are uncertain. The aim of this study was to investigate the associations between long-term UFP exposure and natural and cause-specific mortality (including cardiovascular disease (CVD), respiratory disease, and lung cancer) in the Netherlands. Methods A Dutch national cohort of 10.8 million adults aged ≥ 30 years was followed from 2013 until 2019. Annual average UFP concentrations were estimated at the home address at baseline, using land-use regression models based on a nationwide mobile monitoring campaign performed at the midpoint of the follow-up period. Cox proportional hazard models were applied, adjusting for individual and area-level socio-economic status covariates. Two-pollutant models with the major regulated pollutants nitrogen dioxide (NO2) and fine particles (PM2 . 5 and PM10), and the health relevant combustion aerosol pollutant (elemental carbon (EC)) were assessed based on dispersion modelling. Results A total of 945,615 natural deaths occurred during 71,008,209 person-years of follow-up. The correlation of UFP concentration with other pollutants ranged from moderate (0.59 (PM2 . 5)) to high (0.81 (NO2)). We found a significant association between annual average UFP exposure and natural mortality [HR 1.012 (95 % CI 1.010–1.015), per interquartile range (IQR) (2723 particles/cm3) increment]. Associations were stronger for respiratory disease mortality [HR 1.022 (1.013–1.032)] and lung cancer mortality [HR 1.038 (1.028–1.048)] and weaker for CVD mortality [HR 1.005 (1.000–1.011)]. The associations of UFP with natural and lung cancer mortality attenuated but remained significant in all two-pollutant models, whereas the associations with CVD and respiratory mortality attenuated to the null. Conclusion Long-term UFP exposure was associated with natural and lung cancer mortality among adults independently from other regulated air pollutants.
Long-term exposure to ultrafine particles and natural and cause-specific mortality
https://orcid.org/0000-0002-9085-6026
https://orcid.org/0000-0001-9065-6916
https://orcid.org/0000-0003-3612-5780
Abstract Background Health implications of long-term exposure to ubiquitously present ultrafine particles (UFP) are uncertain. The aim of this study was to investigate the associations between long-term UFP exposure and natural and cause-specific mortality (including cardiovascular disease (CVD), respiratory disease, and lung cancer) in the Netherlands. Methods A Dutch national cohort of 10.8 million adults aged ≥ 30 years was followed from 2013 until 2019. Annual average UFP concentrations were estimated at the home address at baseline, using land-use regression models based on a nationwide mobile monitoring campaign performed at the midpoint of the follow-up period. Cox proportional hazard models were applied, adjusting for individual and area-level socio-economic status covariates. Two-pollutant models with the major regulated pollutants nitrogen dioxide (NO2) and fine particles (PM2 . 5 and PM10), and the health relevant combustion aerosol pollutant (elemental carbon (EC)) were assessed based on dispersion modelling. Results A total of 945,615 natural deaths occurred during 71,008,209 person-years of follow-up. The correlation of UFP concentration with other pollutants ranged from moderate (0.59 (PM2 . 5)) to high (0.81 (NO2)). We found a significant association between annual average UFP exposure and natural mortality [HR 1.012 (95 % CI 1.010–1.015), per interquartile range (IQR) (2723 particles/cm3) increment]. Associations were stronger for respiratory disease mortality [HR 1.022 (1.013–1.032)] and lung cancer mortality [HR 1.038 (1.028–1.048)] and weaker for CVD mortality [HR 1.005 (1.000–1.011)]. The associations of UFP with natural and lung cancer mortality attenuated but remained significant in all two-pollutant models, whereas the associations with CVD and respiratory mortality attenuated to the null. Conclusion Long-term UFP exposure was associated with natural and lung cancer mortality among adults independently from other regulated air pollutants.
Long-term exposure to ultrafine particles and natural and cause-specific mortality
https://orcid.org/0000-0002-9085-6026
https://orcid.org/0000-0001-9065-6916
https://orcid.org/0000-0003-3612-5780
Abstract Background Health implications of long-term exposure to ubiquitously present ultrafine particles (UFP) are uncertain. The aim of this study was to investigate the associations between long-term UFP exposure and natural and cause-specific mortality (including cardiovascular disease (CVD), respiratory disease, and lung cancer) in the Netherlands. Methods A Dutch national cohort of 10.8 million adults aged ≥ 30 years was followed from 2013 until 2019. Annual average UFP concentrations were estimated at the home address at baseline, using land-use regression models based on a nationwide mobile monitoring campaign performed at the midpoint of the follow-up period. Cox proportional hazard models were applied, adjusting for individual and area-level socio-economic status covariates. Two-pollutant models with the major regulated pollutants nitrogen dioxide (NO2) and fine particles (PM2 . 5 and PM10), and the health relevant combustion aerosol pollutant (elemental carbon (EC)) were assessed based on dispersion modelling. Results A total of 945,615 natural deaths occurred during 71,008,209 person-years of follow-up. The correlation of UFP concentration with other pollutants ranged from moderate (0.59 (PM2 . 5)) to high (0.81 (NO2)). We found a significant association between annual average UFP exposure and natural mortality [HR 1.012 (95 % CI 1.010–1.015), per interquartile range (IQR) (2723 particles/cm3) increment]. Associations were stronger for respiratory disease mortality [HR 1.022 (1.013–1.032)] and lung cancer mortality [HR 1.038 (1.028–1.048)] and weaker for CVD mortality [HR 1.005 (1.000–1.011)]. The associations of UFP with natural and lung cancer mortality attenuated but remained significant in all two-pollutant models, whereas the associations with CVD and respiratory mortality attenuated to the null. Conclusion Long-term UFP exposure was associated with natural and lung cancer mortality among adults independently from other regulated air pollutants.
Long-term exposure to ultrafine particles and natural and cause-specific mortality
Bouma, Femke (Autor:in) / Janssen, Nicole AH (Autor:in) / Wesseling, Joost (Autor:in) / van Ratingen, Sjoerd (Autor:in) / Strak, Maciek (Autor:in) / Kerckhoffs, Jules (Autor:in) / Gehring, Ulrike (Autor:in) / Hendricx, Wouter (Autor:in) / de Hoogh, Kees (Autor:in) / Vermeulen, Roel (Autor:in)
03.05.2023
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Long-term exposure to ultrafine particles and natural and cause-specific mortality
| DOAJ | 2023
| Elsevier | 2024