Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Estrogenic endocrine disruptors: Molecular mechanisms of action
Abstract A comprehensive summary of more than 450 estrogenic chemicals including estrogenic endocrine disruptors is provided here to understand the complex and profound impact of estrogen action. First, estrogenic chemicals are categorized by structure as well as their applications, usage and effects. Second, estrogenic signaling is examined by the molecular mechanism based on the receptors, signaling pathways, crosstalk/bypassing and autocrine/paracrine/homeostatic networks involved in the signaling. Third, evaluation of estrogen action is discussed by focusing on the technologies and protocols of the assays for assessing estrogenicity. Understanding the molecular mechanisms of estrogen action is important to assess the action of endocrine disruptors and will be used for risk management based on pathway-based toxicity testing.
Highlights A comprehensive summary of more than 450 estrogenic chemicals is provided. Intracellular and intercellular signaling pathways involved in estrogen signaling are summarized. Potential toxicity pathways that could be used for endocrine disruptor studies are discussed.
Estrogenic endocrine disruptors: Molecular mechanisms of action
Abstract A comprehensive summary of more than 450 estrogenic chemicals including estrogenic endocrine disruptors is provided here to understand the complex and profound impact of estrogen action. First, estrogenic chemicals are categorized by structure as well as their applications, usage and effects. Second, estrogenic signaling is examined by the molecular mechanism based on the receptors, signaling pathways, crosstalk/bypassing and autocrine/paracrine/homeostatic networks involved in the signaling. Third, evaluation of estrogen action is discussed by focusing on the technologies and protocols of the assays for assessing estrogenicity. Understanding the molecular mechanisms of estrogen action is important to assess the action of endocrine disruptors and will be used for risk management based on pathway-based toxicity testing.
Highlights A comprehensive summary of more than 450 estrogenic chemicals is provided. Intracellular and intercellular signaling pathways involved in estrogen signaling are summarized. Potential toxicity pathways that could be used for endocrine disruptor studies are discussed.
Estrogenic endocrine disruptors: Molecular mechanisms of action
Kiyama, Ryoiti (Autor:in) / Wada-Kiyama, Yuko (Autor:in)
Environmental International ; 83 ; 11-40
27.05.2015
30 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Estrogenic endocrine disruptors: Molecular mechanisms of action
| Elsevier | 2015
Estrogenic endocrine disruptors: Molecular mechanisms of action
| Online Contents | 2015
Online SPE-LC-APPI-MS/MS for the quantification of estrogenic endocrine disruptors in water
| British Library Conference Proceedings | 2008
EPA interim report on endocrine disruptors
Online Contents | 1997
Are brominated flame retardants endocrine disruptors?
| Elsevier | 2003