Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) and survival following breast cancer in the Carolina Breast Cancer Study
https://orcid.org/0000-0001-6562-8577
Abstract Objectives To examine plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) in association with survival among women with breast cancer who participated in a population-based case-control study. Methods Participants included 456 white and 292 black women from the Carolina Breast Cancer Study Phase I who were diagnosed with primary invasive breast cancer from 1993 to 1996, and who had available DDE/DDT and lipid measurements from blood samples obtained on average 4.1 months after diagnosis. Using the National Death Index, we identified 392 deaths (210 from breast cancer) over a median follow-up of 20.6 years. We used Cox regression to estimate covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and breast cancer-specific 5-year mortality, and 20-year mortality conditional on 5-year survival, for lipid-standardized DDE and DDT levels. Associations stratified by race and estrogen receptor (ER) status were also examined. Results The highest versus lowest DDE tertile and the highest vs non-detectable DDT quantile were associated with HRs of 1.95 (95% CI = 1.31–2.92) and 1.64 (95% CI = 1.10–2.44), respectively, for 20-year conditional all-cause mortality. DDE levels above versus below the median were associated with a HR of 1.69 (95% CI = 1.06–2.68) for 20-year conditional breast cancer-specific mortality among women overall, and HRs were 2.36 (95% CI = 1.03–5.42) among black women and 1.57 (95% CI = 0.86–2.89) among white women (P Interaction = 0.42), and 3.24 (95% CI = 1.38–7.58) among women with ER− tumors and 1.29 (95% CI = 0.73–2.28) among women with ER+ tumors (P Interaction = 0.03). Conclusion Exposure to DDE/DDT may adversely impact overall and breast cancer-specific survival. DDE exposure may contribute to the racial disparities in breast cancer survival.
Highlights Higher DDE and DDT levels were associated with worse overall survival. Higher DDE levels were associated with worse breast cancer-specific survival. Mortality rates were elevated more so among black women than among white women. Mortality rates were elevated more so among women with ER− than ER+ breast cancer.
Plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) and survival following breast cancer in the Carolina Breast Cancer Study
https://orcid.org/0000-0001-6562-8577
Abstract Objectives To examine plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) in association with survival among women with breast cancer who participated in a population-based case-control study. Methods Participants included 456 white and 292 black women from the Carolina Breast Cancer Study Phase I who were diagnosed with primary invasive breast cancer from 1993 to 1996, and who had available DDE/DDT and lipid measurements from blood samples obtained on average 4.1 months after diagnosis. Using the National Death Index, we identified 392 deaths (210 from breast cancer) over a median follow-up of 20.6 years. We used Cox regression to estimate covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and breast cancer-specific 5-year mortality, and 20-year mortality conditional on 5-year survival, for lipid-standardized DDE and DDT levels. Associations stratified by race and estrogen receptor (ER) status were also examined. Results The highest versus lowest DDE tertile and the highest vs non-detectable DDT quantile were associated with HRs of 1.95 (95% CI = 1.31–2.92) and 1.64 (95% CI = 1.10–2.44), respectively, for 20-year conditional all-cause mortality. DDE levels above versus below the median were associated with a HR of 1.69 (95% CI = 1.06–2.68) for 20-year conditional breast cancer-specific mortality among women overall, and HRs were 2.36 (95% CI = 1.03–5.42) among black women and 1.57 (95% CI = 0.86–2.89) among white women (P Interaction = 0.42), and 3.24 (95% CI = 1.38–7.58) among women with ER− tumors and 1.29 (95% CI = 0.73–2.28) among women with ER+ tumors (P Interaction = 0.03). Conclusion Exposure to DDE/DDT may adversely impact overall and breast cancer-specific survival. DDE exposure may contribute to the racial disparities in breast cancer survival.
Highlights Higher DDE and DDT levels were associated with worse overall survival. Higher DDE levels were associated with worse breast cancer-specific survival. Mortality rates were elevated more so among black women than among white women. Mortality rates were elevated more so among women with ER− than ER+ breast cancer.
Plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) and survival following breast cancer in the Carolina Breast Cancer Study
https://orcid.org/0000-0001-6562-8577
Abstract Objectives To examine plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) in association with survival among women with breast cancer who participated in a population-based case-control study. Methods Participants included 456 white and 292 black women from the Carolina Breast Cancer Study Phase I who were diagnosed with primary invasive breast cancer from 1993 to 1996, and who had available DDE/DDT and lipid measurements from blood samples obtained on average 4.1 months after diagnosis. Using the National Death Index, we identified 392 deaths (210 from breast cancer) over a median follow-up of 20.6 years. We used Cox regression to estimate covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and breast cancer-specific 5-year mortality, and 20-year mortality conditional on 5-year survival, for lipid-standardized DDE and DDT levels. Associations stratified by race and estrogen receptor (ER) status were also examined. Results The highest versus lowest DDE tertile and the highest vs non-detectable DDT quantile were associated with HRs of 1.95 (95% CI = 1.31–2.92) and 1.64 (95% CI = 1.10–2.44), respectively, for 20-year conditional all-cause mortality. DDE levels above versus below the median were associated with a HR of 1.69 (95% CI = 1.06–2.68) for 20-year conditional breast cancer-specific mortality among women overall, and HRs were 2.36 (95% CI = 1.03–5.42) among black women and 1.57 (95% CI = 0.86–2.89) among white women (P Interaction = 0.42), and 3.24 (95% CI = 1.38–7.58) among women with ER− tumors and 1.29 (95% CI = 0.73–2.28) among women with ER+ tumors (P Interaction = 0.03). Conclusion Exposure to DDE/DDT may adversely impact overall and breast cancer-specific survival. DDE exposure may contribute to the racial disparities in breast cancer survival.
Highlights Higher DDE and DDT levels were associated with worse overall survival. Higher DDE levels were associated with worse breast cancer-specific survival. Mortality rates were elevated more so among black women than among white women. Mortality rates were elevated more so among women with ER− than ER+ breast cancer.
Plasma levels of dichlorodiphenyldichloroethene (DDE) and dichlorodiphenyltrichloroethane (DDT) and survival following breast cancer in the Carolina Breast Cancer Study
Parada, Humberto Jr (Autor:in) / Sun, Xuezheng (Autor:in) / Tse, Chiu-Kit (Autor:in) / Engel, Lawrence S. (Autor:in) / Olshan, Andrew F. (Autor:in) / Troester, Melissa A. (Autor:in)
Environmental International ; 125 ; 161-171
11.01.2019
11 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Male fertility following occupational exposure to dichlorodiphenyltrichloroethane (DDT)
| Online Contents | 2015