Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Assessment of cadmium bioaccessibility to predict its bioavailability in contaminated soils
https://orcid.org/0000-0002-8463-9957
Abstract In vitro assays have been developed to determine metal bioaccessibility in contaminated soils; however, their application to Cd is limited. To assess their suitability to determine Cd relative bioavailability (RBA), Cd-RBA in 12 contaminated soils containing 3.00–296mgkg−1 Cd were determined using a mouse model and compared with Cd bioaccessibility data based on four assays including the UBM, SBRC, IVG, and PBET. After being administered feed amended with soil or CdCl2 for 10-day, the Cd concentrations in the mouse liver and/or kidneys were used as biomarkers to estimate Cd-RBA. Cd-RBA was comparable at 34–90% and 40–78% based on mouse liver and kidneys with RSD of 7.10–8.99%, and 37–84% based on mouse liver plus kidneys with lower RSD of 5.8%. Cadmium bioaccessibility in soils varied with assays, with 61–99, 59–103, 54–107, and 35–97% in the gastric phase and 20–56, 38–77, 42–88, and 19–64% in the intestinal phase of the UBM, SBRC, IVG and PBET assays. Based on the combined biomarker of liver plus kidneys, better correlation was observed for PBET (r2 =0.61–0.70) than those for IVG, UBM and SBRC assays (0.12–0.52). The monthly Cd intake in children was 0.24–23.9μgkg−1 using total Cd concentration in soils, which was reduced by 43% to 0.18–12.3μgkg−1 using bioavailable Cd. Our data suggest it is important to consider Cd-RBA to assess risk associated with contaminated soils and the PBET may have potential to predict Cd-RBA in contaminated soils.
Graphical abstract Display Omitted
Highlights Cd bioaccessibility in soils was determined using UBM, SBRC, IVG, and PBET assays. Cd relative bioavailability in contaminated soils was determined using a mouse model. A 10-d steady state dosing was used with Cd in kidneys plus liver as a biomarker. PBET has the potential to predict Cd bioavailability in contaminated soils.
Assessment of cadmium bioaccessibility to predict its bioavailability in contaminated soils
https://orcid.org/0000-0002-8463-9957
Abstract In vitro assays have been developed to determine metal bioaccessibility in contaminated soils; however, their application to Cd is limited. To assess their suitability to determine Cd relative bioavailability (RBA), Cd-RBA in 12 contaminated soils containing 3.00–296mgkg−1 Cd were determined using a mouse model and compared with Cd bioaccessibility data based on four assays including the UBM, SBRC, IVG, and PBET. After being administered feed amended with soil or CdCl2 for 10-day, the Cd concentrations in the mouse liver and/or kidneys were used as biomarkers to estimate Cd-RBA. Cd-RBA was comparable at 34–90% and 40–78% based on mouse liver and kidneys with RSD of 7.10–8.99%, and 37–84% based on mouse liver plus kidneys with lower RSD of 5.8%. Cadmium bioaccessibility in soils varied with assays, with 61–99, 59–103, 54–107, and 35–97% in the gastric phase and 20–56, 38–77, 42–88, and 19–64% in the intestinal phase of the UBM, SBRC, IVG and PBET assays. Based on the combined biomarker of liver plus kidneys, better correlation was observed for PBET (r2 =0.61–0.70) than those for IVG, UBM and SBRC assays (0.12–0.52). The monthly Cd intake in children was 0.24–23.9μgkg−1 using total Cd concentration in soils, which was reduced by 43% to 0.18–12.3μgkg−1 using bioavailable Cd. Our data suggest it is important to consider Cd-RBA to assess risk associated with contaminated soils and the PBET may have potential to predict Cd-RBA in contaminated soils.
Graphical abstract Display Omitted
Highlights Cd bioaccessibility in soils was determined using UBM, SBRC, IVG, and PBET assays. Cd relative bioavailability in contaminated soils was determined using a mouse model. A 10-d steady state dosing was used with Cd in kidneys plus liver as a biomarker. PBET has the potential to predict Cd bioavailability in contaminated soils.
Assessment of cadmium bioaccessibility to predict its bioavailability in contaminated soils
https://orcid.org/0000-0002-8463-9957
Abstract In vitro assays have been developed to determine metal bioaccessibility in contaminated soils; however, their application to Cd is limited. To assess their suitability to determine Cd relative bioavailability (RBA), Cd-RBA in 12 contaminated soils containing 3.00–296mgkg−1 Cd were determined using a mouse model and compared with Cd bioaccessibility data based on four assays including the UBM, SBRC, IVG, and PBET. After being administered feed amended with soil or CdCl2 for 10-day, the Cd concentrations in the mouse liver and/or kidneys were used as biomarkers to estimate Cd-RBA. Cd-RBA was comparable at 34–90% and 40–78% based on mouse liver and kidneys with RSD of 7.10–8.99%, and 37–84% based on mouse liver plus kidneys with lower RSD of 5.8%. Cadmium bioaccessibility in soils varied with assays, with 61–99, 59–103, 54–107, and 35–97% in the gastric phase and 20–56, 38–77, 42–88, and 19–64% in the intestinal phase of the UBM, SBRC, IVG and PBET assays. Based on the combined biomarker of liver plus kidneys, better correlation was observed for PBET (r2 =0.61–0.70) than those for IVG, UBM and SBRC assays (0.12–0.52). The monthly Cd intake in children was 0.24–23.9μgkg−1 using total Cd concentration in soils, which was reduced by 43% to 0.18–12.3μgkg−1 using bioavailable Cd. Our data suggest it is important to consider Cd-RBA to assess risk associated with contaminated soils and the PBET may have potential to predict Cd-RBA in contaminated soils.
Graphical abstract Display Omitted
Highlights Cd bioaccessibility in soils was determined using UBM, SBRC, IVG, and PBET assays. Cd relative bioavailability in contaminated soils was determined using a mouse model. A 10-d steady state dosing was used with Cd in kidneys plus liver as a biomarker. PBET has the potential to predict Cd bioavailability in contaminated soils.
Assessment of cadmium bioaccessibility to predict its bioavailability in contaminated soils
Li, Shi-Wei (Autor:in) / Sun, Hong-Jie (Autor:in) / Li, Hong-Bo (Autor:in) / Luo, Jun (Autor:in) / Ma, Lena Q. (Autor:in)
Environmental International ; 94 ; 600-606
16.06.2016
7 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Bioavailability , Heavy metal , Kidneys , Liver , Biomarker , Contamination
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