Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Parental occupational exposure to pesticides as risk factor for brain tumors in children and young adults: A systematic review and meta-analysis
Abstract Objective To examine the potential association between parental occupational exposure to pesticides and the occurrence of brain tumors in children and young adults. Methods Studies identified from a MEDLINE search through 15 January 2013 and from the reference lists of identified publications were submitted to a systematic review and meta-analysis. Relative risk estimates were extracted from 20 studies published between 1974 and 2010. Most of the retrieved studies involved farm/agricultural jobs. Summary ratio estimates (SR) were calculated according to fixed and random-effect meta-analysis models. Separate analyses were conducted after stratification for study design, exposure parameters, disease definition, geographic location and age at diagnosis. Results Statistically significant associations were observed for parents potentially exposed to pesticides in occupational settings and the occurrence of brain tumor in their offspring after combining all case–control studies (summary odds ratio [SOR]: 1.30; 95%: 1.11, 1.53) or all cohort studies (summary rate ratio [SRR]: 1.53; 95% CI: 1.20, 1.95). Significantly increased risks were seen for prenatal exposure windows, for either exposed parent, for exposure defined as to pesticides as well as by occupational/industry title, for astroglial brain tumors and after combining case–control studies from North America or cohort studies from Europe. Conclusions This meta-analysis supports an association between parental occupational exposure to pesticides and brain tumors in children and young adults, and adds to the evidence leading to the recommendation of minimizing (parental) occupational exposure to pesticides. These results must, however, be interpreted with caution because the impact of work-related factors others than pesticide exposure is not known.
Highlights Relative risk estimates extracted from 20 case-control and cohort studies. Significant association between parental job-related exposure to pesticides and brain tumor in children. Significant association for either exposed parent, exposure defined as to pesticides or by job title, astroglial tumor. Results to be interpreted with caution, potential impact of other factors not known.
Parental occupational exposure to pesticides as risk factor for brain tumors in children and young adults: A systematic review and meta-analysis
Abstract Objective To examine the potential association between parental occupational exposure to pesticides and the occurrence of brain tumors in children and young adults. Methods Studies identified from a MEDLINE search through 15 January 2013 and from the reference lists of identified publications were submitted to a systematic review and meta-analysis. Relative risk estimates were extracted from 20 studies published between 1974 and 2010. Most of the retrieved studies involved farm/agricultural jobs. Summary ratio estimates (SR) were calculated according to fixed and random-effect meta-analysis models. Separate analyses were conducted after stratification for study design, exposure parameters, disease definition, geographic location and age at diagnosis. Results Statistically significant associations were observed for parents potentially exposed to pesticides in occupational settings and the occurrence of brain tumor in their offspring after combining all case–control studies (summary odds ratio [SOR]: 1.30; 95%: 1.11, 1.53) or all cohort studies (summary rate ratio [SRR]: 1.53; 95% CI: 1.20, 1.95). Significantly increased risks were seen for prenatal exposure windows, for either exposed parent, for exposure defined as to pesticides as well as by occupational/industry title, for astroglial brain tumors and after combining case–control studies from North America or cohort studies from Europe. Conclusions This meta-analysis supports an association between parental occupational exposure to pesticides and brain tumors in children and young adults, and adds to the evidence leading to the recommendation of minimizing (parental) occupational exposure to pesticides. These results must, however, be interpreted with caution because the impact of work-related factors others than pesticide exposure is not known.
Highlights Relative risk estimates extracted from 20 case-control and cohort studies. Significant association between parental job-related exposure to pesticides and brain tumor in children. Significant association for either exposed parent, exposure defined as to pesticides or by job title, astroglial tumor. Results to be interpreted with caution, potential impact of other factors not known.
Parental occupational exposure to pesticides as risk factor for brain tumors in children and young adults: A systematic review and meta-analysis
Van Maele-Fabry, Geneviève (Autor:in) / Hoet, Perrine (Autor:in) / Lison, Dominique (Autor:in)
Environmental International ; 56 ; 19-31
22.02.2013
13 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
ASTRO , astroglial brain tumors , 95% CI , 95% confidence interval , ICD , international classification of disease , SR , summary ratio estimate , SIR , standardized incidence ratio , SOR , summary odds ratio , SRR , summary risk ratio , OR , odds ratio , PNET , primitive neuroectodermal tumors , RR , relative risk , 95% UI , 95% uncertainty interval , Child , Brain tumors , Parental occupational exposure , Pesticides , Systematic review , Meta-analysis