Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Personal exposure to fine particulate matter and blood pressure: A role of angiotensin converting enzyme and its DNA methylation
Abstract Background The underlying intermediate mechanisms about the association between fine particulate matter (PM2.5) air pollution and blood pressure (BP) were unclear. Few epidemiological studies have explored the potential mediation effects of angiotensin-converting enzyme (ACE) and its DNA methylation. Methods We designed a longitudinal panel study with 4 follow-ups among 36 healthy college students in Shanghai, China from December 17, 2014 to July 11, 2015. We measured personal real-time exposure to PM2.5, serum ACE level, and blood methylation of ACE gene and the repetitive elements. We applied linear mixed-effects models to examine the effects of PM2.5 on ACE protein, DNA methylation and BP markers. Furthermore, we conducted mediation analyses to evaluate the potential pathways. Results An interquartile range increase (26.78μg/m3) in 24-h average exposure to PM2.5 was significantly associated with 1.12 decreases in ACE average methylation (%5mC), 13.27% increase in ACE protein, and increments of 1.13mmHg in systolic BP, 0.66mmHg in diastolic BP and 0.82mmHg in mean arterial pressure. ACE hypomethylation mediated 11.78% (P=0.03) of the elevated ACE protein by PM2.5. Increased ACE protein accounted for 3.90~13.44% (P=0.35~0.68) of the elevated BP by PM2.5. Repetitive-element methylation was also decreased but did not significantly mediate the association between PM2.5 and BP. Conclusions This investigation provided strong evidence that short-term exposure to PM2.5 was significantly associated with BP, ACE protein and ACE methylation. Our findings highlighted a possible involvement of ACE and ACE methylation in the effects of PM2.5 on elevating BP.
Highlights Personal exposure to PM2.5 was significantly associated with elevated BP. The first study examining the mediation of ACE protein in the effects of PM2.5 on BP. The first study examining the effects of PM2.5 on ACE methylation. ACE and ACE methylation may mediate the effects of PM2.5 on BP.
Personal exposure to fine particulate matter and blood pressure: A role of angiotensin converting enzyme and its DNA methylation
Abstract Background The underlying intermediate mechanisms about the association between fine particulate matter (PM2.5) air pollution and blood pressure (BP) were unclear. Few epidemiological studies have explored the potential mediation effects of angiotensin-converting enzyme (ACE) and its DNA methylation. Methods We designed a longitudinal panel study with 4 follow-ups among 36 healthy college students in Shanghai, China from December 17, 2014 to July 11, 2015. We measured personal real-time exposure to PM2.5, serum ACE level, and blood methylation of ACE gene and the repetitive elements. We applied linear mixed-effects models to examine the effects of PM2.5 on ACE protein, DNA methylation and BP markers. Furthermore, we conducted mediation analyses to evaluate the potential pathways. Results An interquartile range increase (26.78μg/m3) in 24-h average exposure to PM2.5 was significantly associated with 1.12 decreases in ACE average methylation (%5mC), 13.27% increase in ACE protein, and increments of 1.13mmHg in systolic BP, 0.66mmHg in diastolic BP and 0.82mmHg in mean arterial pressure. ACE hypomethylation mediated 11.78% (P=0.03) of the elevated ACE protein by PM2.5. Increased ACE protein accounted for 3.90~13.44% (P=0.35~0.68) of the elevated BP by PM2.5. Repetitive-element methylation was also decreased but did not significantly mediate the association between PM2.5 and BP. Conclusions This investigation provided strong evidence that short-term exposure to PM2.5 was significantly associated with BP, ACE protein and ACE methylation. Our findings highlighted a possible involvement of ACE and ACE methylation in the effects of PM2.5 on elevating BP.
Highlights Personal exposure to PM2.5 was significantly associated with elevated BP. The first study examining the mediation of ACE protein in the effects of PM2.5 on BP. The first study examining the effects of PM2.5 on ACE methylation. ACE and ACE methylation may mediate the effects of PM2.5 on BP.
Personal exposure to fine particulate matter and blood pressure: A role of angiotensin converting enzyme and its DNA methylation
Wang, Cuicui (Autor:in) / Chen, Renjie (Autor:in) / Cai, Jing (Autor:in) / Shi, Jingjin (Autor:in) / Yang, Changyuan (Autor:in) / Tse, Lap Ah. (Autor:in) / Li, Huichu (Autor:in) / Lin, Zhijing (Autor:in) / Meng, Xia (Autor:in) / Liu, Cong (Autor:in)
Environmental International ; 94 ; 661-666
01.07.2016
6 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
PM<inf>2.5</inf> , fine particulate matter , CVDs , cardiovascular diseases , BP , blood pressure , ACE , angiotensin-converting enzyme , <italic>LINE-1</italic> , long interspersed nucleotide element-1 , SBP , systolic blood pressure , DBP , diastolic blood pressure , MAP , mean arterial pressure , LME , linear mixed-effect model , IQR , interquartile range , CI , confidence interval , SD , standard deviation , RAS , renin–angiotensin system , Ang II , angiotensin II , Fine particulate matter , Blood pressure , Angiotensin-converting enzyme , DNA methylation , Panel study
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| Elsevier | 2021
Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth
| DOAJ | 2021