Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Organophosphate pesticide exposure and perinatal outcomes in Shanghai, China
Abstract Although pesticide use is widespread in China, little is known about levels of exposure to organophosphate pesticides in the population and its potential adverse health effects. We investigated levels of organophosphate exposure in pregnant women and the association between organophosphate exposure and perinatal outcomes in Shanghai, China, by enrolling 187 healthy pregnant women between September 2006 and January 2007. Pesticide exposure was assessed by a questionnaire administered to the mothers in the hospital after delivery as well as by analyses of maternal urinary nonspecific metabolites of organophosphate pesticides (dimethyl and diethyl phosphates). Information on birth weight and length was collected from medical records. Geometric means of metabolites were 25.75μg/L for dimethylphosphate (DMP); 11.99μg/L for dimethylthiophosphate (DMTP); 9.03μg/L for diethylphosphate (DEP); and 9.45μg/L for diethyldithiophosphate (DETP). We found that a log unit increase in urinary DEP was associated with a decrease in gestational duration in girls by 1.79weeks. [ßadjusted =−1.79weeks per log10 unit increase; 95% confidence interval (CI), −2.82 to −0.76; p=0.001]. These data suggest that high pesticide level might adversely affect duration of gestation although this association was not present among boys. No associations for any of the organophosphate exposure measures were present for birth weight and length, suggesting that organophosphate pesticides may have no effects on fetal growth. Given that maternal urine pesticide levels in Shanghai were much higher than those reported in developed countries, more studies on the effects of in utero organophosphate exposure on fetal growth and child neurodevelopment are warranted.
Research highlights ► We examined possible adverse effects of prenatal exposure to organophosphate pesticide on perinatal outcomes in Shanghai. ► High urine levels of organophosphate pesticide were found in pregnant women. ► High pesticides level might adversely affect duration of gestation. ► No relationship was found between fetal growth and organophosphate pesticide exposure.
Organophosphate pesticide exposure and perinatal outcomes in Shanghai, China
Abstract Although pesticide use is widespread in China, little is known about levels of exposure to organophosphate pesticides in the population and its potential adverse health effects. We investigated levels of organophosphate exposure in pregnant women and the association between organophosphate exposure and perinatal outcomes in Shanghai, China, by enrolling 187 healthy pregnant women between September 2006 and January 2007. Pesticide exposure was assessed by a questionnaire administered to the mothers in the hospital after delivery as well as by analyses of maternal urinary nonspecific metabolites of organophosphate pesticides (dimethyl and diethyl phosphates). Information on birth weight and length was collected from medical records. Geometric means of metabolites were 25.75μg/L for dimethylphosphate (DMP); 11.99μg/L for dimethylthiophosphate (DMTP); 9.03μg/L for diethylphosphate (DEP); and 9.45μg/L for diethyldithiophosphate (DETP). We found that a log unit increase in urinary DEP was associated with a decrease in gestational duration in girls by 1.79weeks. [ßadjusted =−1.79weeks per log10 unit increase; 95% confidence interval (CI), −2.82 to −0.76; p=0.001]. These data suggest that high pesticide level might adversely affect duration of gestation although this association was not present among boys. No associations for any of the organophosphate exposure measures were present for birth weight and length, suggesting that organophosphate pesticides may have no effects on fetal growth. Given that maternal urine pesticide levels in Shanghai were much higher than those reported in developed countries, more studies on the effects of in utero organophosphate exposure on fetal growth and child neurodevelopment are warranted.
Research highlights ► We examined possible adverse effects of prenatal exposure to organophosphate pesticide on perinatal outcomes in Shanghai. ► High urine levels of organophosphate pesticide were found in pregnant women. ► High pesticides level might adversely affect duration of gestation. ► No relationship was found between fetal growth and organophosphate pesticide exposure.
Organophosphate pesticide exposure and perinatal outcomes in Shanghai, China
Wang, Pei (Autor:in) / Tian, Ying (Autor:in) / Wang, Xiao-Jin (Autor:in) / Gao, Yu (Autor:in) / Shi, Rong (Autor:in) / Wang, Guo-Quan (Autor:in) / Hu, Guo-Hua (Autor:in) / Shen, Xiao-Ming (Autor:in)
Environmental International ; 42 ; 100-104
01.01.2011
5 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
CDC , Centers for Disease Control and Prevention , CV , coefficient of variation , DAP , dialkylphosphate , DEDTP , diethyldithiophosphate , DEP , diethylphosphate , DETP , DMP , dimethylphosphate , DMTP , dimethylthiophosphate , LOD , Limit of Detection , GM , geometric mean , QC , quality control , AchE , acetylcholinesterase , Birth outcome , Birth weight , Gestational age , Organophosphate pesticide , Urinary metabolite
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