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Characterization of Venezuelan kaolins as health care ingredients
Abstract Characterization directed to evaluate health care usefulness of kaolinitic samples from various deposits from the south of Venezuela exploited used as raw materials in ceramics have been done Identity, purity and richness in mineral phases and presence of chemical impurities were compared to pharmaceutical grade kaolins and correlated to international requirements described in pharmacopoeias. Color parameters and textural analysis were used as a complementary characterization of the suitability of the samples as a diluent for pharmaceutical oral dosage forms. Most of the samples would require purification before considering their use as health care ingredients. In particular, treatment to eliminate quartz as a mineral impurity or Pb as metallic impurity would be advisable for some of the studied kaolins. Nevertheless, at least seven of the studied samples could be used directly, as they are comparable to commercial kaolin used as excipients or cosmetic ingredients.
Highlights Health care usefullness of fourteen Venezuelan kaolins have been determined. Kaolinite content in seven of the samples was higher or similar to pharmaceutical kaolins. The presence of heavy metals or other impurities limit the possibilities of some high purity kaolinitic samples. Some samples comply with identity and safety quality requirements to be used as health care ingredients.
Characterization of Venezuelan kaolins as health care ingredients
Abstract Characterization directed to evaluate health care usefulness of kaolinitic samples from various deposits from the south of Venezuela exploited used as raw materials in ceramics have been done Identity, purity and richness in mineral phases and presence of chemical impurities were compared to pharmaceutical grade kaolins and correlated to international requirements described in pharmacopoeias. Color parameters and textural analysis were used as a complementary characterization of the suitability of the samples as a diluent for pharmaceutical oral dosage forms. Most of the samples would require purification before considering their use as health care ingredients. In particular, treatment to eliminate quartz as a mineral impurity or Pb as metallic impurity would be advisable for some of the studied kaolins. Nevertheless, at least seven of the studied samples could be used directly, as they are comparable to commercial kaolin used as excipients or cosmetic ingredients.
Highlights Health care usefullness of fourteen Venezuelan kaolins have been determined. Kaolinite content in seven of the samples was higher or similar to pharmaceutical kaolins. The presence of heavy metals or other impurities limit the possibilities of some high purity kaolinitic samples. Some samples comply with identity and safety quality requirements to be used as health care ingredients.
Characterization of Venezuelan kaolins as health care ingredients
Hernández, Ana C. (Autor:in) / Sánchez-Espejo, Rita (Autor:in) / Meléndez, Williams (Autor:in) / González, Gema (Autor:in) / López-Galindo, Alberto (Autor:in) / Viseras, César (Autor:in)
Applied Clay Science ; 175 ; 30-39
05.01.2019
10 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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