Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Exposure to phthalates, bisphenol A and metals in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC study
Abstract Background Studies from several countries report increases in rates of gestational diabetes mellitus (GDM) over recent decades. Exposure to environmental chemicals could contribute to this trend. Objectives To determine the associations between plasticisers and metals measured in early pregnancy with impaired glucose tolerance (IGT) and GDM in a Canadian pregnancy cohort. Methods Women enrolled in the Maternal–Infant Research on Environmental Chemicals (MIREC) Study were included if they had a singleton delivery and did not have pre-existing diabetes. Eleven phthalate metabolites and total bisphenol A (BPA) were measured in first-trimester urine samples, and four metals (lead, cadmium, mercury and arsenic) were measured in first-trimester blood samples. IGT and GDM were assessed in accordance with standard guidelines by chart review. Chemical concentrations were grouped by quartiles, and associations with outcomes were examined using logistic regression with adjustment for maternal age, race, pre-pregnancy BMI, and education. Restricted cubic spline analysis was performed to help assess linearity and nature of any dose–response relationships. Results Of 2001 women recruited into the MIREC cohort, 1274 met the inclusion criteria and had outcome data and biomonitoring data measured for at least one of the chemicals we examined. Elevated odds of GDM were observed in the highest quartile of arsenic exposure (OR=3.7, 95% CI=1.4–9.6) in the adjusted analyses. A significant dose–response relationship was observed in a cubic spline model between arsenic and odds of GDM (p<0.01). No statistically significant associations were observed between phthalates or BPA or other metals with IGT or GDM. Conclusions Our findings add to the growing body of evidence supporting the role of maternal arsenic exposure as a risk factor for gestational diabetes.
Highlights Environmental chemical exposure may be a risk factor for gestational diabetes. We examined relationships between metals, plasticizers and gestational diabetes. Maternal arsenic levels were associated with increased gestational diabetes risk. Phthalate and bisphenol A exposure was not associated with gestational diabetes.
Exposure to phthalates, bisphenol A and metals in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC study
Abstract Background Studies from several countries report increases in rates of gestational diabetes mellitus (GDM) over recent decades. Exposure to environmental chemicals could contribute to this trend. Objectives To determine the associations between plasticisers and metals measured in early pregnancy with impaired glucose tolerance (IGT) and GDM in a Canadian pregnancy cohort. Methods Women enrolled in the Maternal–Infant Research on Environmental Chemicals (MIREC) Study were included if they had a singleton delivery and did not have pre-existing diabetes. Eleven phthalate metabolites and total bisphenol A (BPA) were measured in first-trimester urine samples, and four metals (lead, cadmium, mercury and arsenic) were measured in first-trimester blood samples. IGT and GDM were assessed in accordance with standard guidelines by chart review. Chemical concentrations were grouped by quartiles, and associations with outcomes were examined using logistic regression with adjustment for maternal age, race, pre-pregnancy BMI, and education. Restricted cubic spline analysis was performed to help assess linearity and nature of any dose–response relationships. Results Of 2001 women recruited into the MIREC cohort, 1274 met the inclusion criteria and had outcome data and biomonitoring data measured for at least one of the chemicals we examined. Elevated odds of GDM were observed in the highest quartile of arsenic exposure (OR=3.7, 95% CI=1.4–9.6) in the adjusted analyses. A significant dose–response relationship was observed in a cubic spline model between arsenic and odds of GDM (p<0.01). No statistically significant associations were observed between phthalates or BPA or other metals with IGT or GDM. Conclusions Our findings add to the growing body of evidence supporting the role of maternal arsenic exposure as a risk factor for gestational diabetes.
Highlights Environmental chemical exposure may be a risk factor for gestational diabetes. We examined relationships between metals, plasticizers and gestational diabetes. Maternal arsenic levels were associated with increased gestational diabetes risk. Phthalate and bisphenol A exposure was not associated with gestational diabetes.
Exposure to phthalates, bisphenol A and metals in pregnancy and the association with impaired glucose tolerance and gestational diabetes mellitus: The MIREC study
Shapiro, G.D. (Autor:in) / Dodds, L. (Autor:in) / Arbuckle, T.E. (Autor:in) / Ashley-Martin, J. (Autor:in) / Fraser, W. (Autor:in) / Fisher, M. (Autor:in) / Taback, S. (Autor:in) / Keely, E. (Autor:in) / Bouchard, M.F. (Autor:in) / Monnier, P. (Autor:in)
Environmental International ; 83 ; 63-71
24.05.2015
9 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
BMI , body mass index , BPA , bisphenol A , CRP , C-reactive protein , DEHP , di(2-ethylhexyl)phthalate , EDC , endocrine disrupting chemical , GCT , glucose challenge test , GDM , gestational diabetes mellitus , IGT , impaired glucose tolerance , LOD , limit of detection , MBP , mono-n-butyl phthalate , MBzP , mono-benzyl phthalate , MCHP , monocyclohexyl phthalate , MCPP , mono-3-carboxypropyl phthalate , MEHHP , mono-(2-ethyl-5-hydroxyhexyl) phthalate , MEHP , monoethylhexyl phthalate , MEOHP , mono-(2-ethyl-5-oxohexyl) phthalate , MEP , monoethyl phthalate , MiBP , mono-isobutylphthalate , MIREC , Maternal–Infant Research on Environmental Chemicals , MMP , monomethyl phthalate , MNP , mono-isononyl phthalate , MOP , mono-n-octyl phthalate , NHANES , National Health and Nutrition Examination Survey , NHS , Nurses' Health Study , OGTT , oral glucose tolerance test , PPAR , peroxisome proliferator–activated receptor , SG , specific gravity , UPLC , ultra performance liquid chromatography , Metals , Phthalates , Gestational diabetes , Cohort study , Pregnancy , Arsenic
Prenatal exposure to phthalates and phenols and infant endocrine-sensitive outcomes: The MIREC study
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