Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Interaction of life-time and early-life exposure to antibiotics and indoor environmental factors on childhood plant allergy
https://orcid.org/0000-0002-0110-9492
https://orcid.org/0000-0002-2945-4685
Abstract Background Doctor-diagnosed plant allergy (DPA) in children has emerged as a significant global public health concern. However, the role of antibiotics and indoor environmental factors (IEFs) in childhood DPA remains unknown. Objective To investigate the correlations between childhood DPA and exposure to antibiotics and IEFs during different time periods. Methods A retrospective cohort study of 8,689 preschoolers was performed in Changsha, China. We collected data on each child's health outcomes, antibiotics use and home environment by a questionnaire, as well as temperature and air pollutants in Changsha, and calculated personal exposure to temperature and pollutants. Multiple logistic regression models were used to assess the independent and joint effects of antibiotics and IEFs on childhood DPA. Results Life-time and early-life antibiotics use was associated with childhood DPA with ORs (95% CI) = 1.58 (1.15–2.17) and 1.33 (1.04–1.69), with a higher risk for early-life exposure than later-life exposure. Renovation-specific indoor air pollution (IAP) during pre-birth (1 year before pregnancy and pregnancy) and smoke-specific IAP during early life (pregnancy and first year) had significantly impacts on childhood DPA. Furthermore, dampness-specific allergens throughout lifetime elevated the risk of DPA, with ORs ranging from 1.34 (1.00–1.81) to 1.93 (1.44–2.59). Moreover, life-time and early-life antibiotic use significantly increased the DPA risk attributed to some specific IEFs, such as ETS especially grandparental smoking, exposure during first year and previous year, with a significant interaction. Conclusions Life-time and early-life exposure to antibiotics and IEFs independently and jointly played key roles in the development of DPA, supporting the “fetal origin of childhood PA” hypothesis.
Graphical abstract Display Omitted
Highlights Life-time and early-life antibiotic use increased the risk of childhood plant allergy (PA). Renovation-specific indoor air pollution (IAP) exposure before birth elevated the risk of PA. Smoke-specific IAP exposure during early life was associated with increased risk of PA. Dampness-specific indoor allergens exposure throughout lifetime was related with PA risk. Antibiotic use significantly increased childhood PA risk attributed to smoke-specific IAP.
Interaction of life-time and early-life exposure to antibiotics and indoor environmental factors on childhood plant allergy
https://orcid.org/0000-0002-0110-9492
https://orcid.org/0000-0002-2945-4685
Abstract Background Doctor-diagnosed plant allergy (DPA) in children has emerged as a significant global public health concern. However, the role of antibiotics and indoor environmental factors (IEFs) in childhood DPA remains unknown. Objective To investigate the correlations between childhood DPA and exposure to antibiotics and IEFs during different time periods. Methods A retrospective cohort study of 8,689 preschoolers was performed in Changsha, China. We collected data on each child's health outcomes, antibiotics use and home environment by a questionnaire, as well as temperature and air pollutants in Changsha, and calculated personal exposure to temperature and pollutants. Multiple logistic regression models were used to assess the independent and joint effects of antibiotics and IEFs on childhood DPA. Results Life-time and early-life antibiotics use was associated with childhood DPA with ORs (95% CI) = 1.58 (1.15–2.17) and 1.33 (1.04–1.69), with a higher risk for early-life exposure than later-life exposure. Renovation-specific indoor air pollution (IAP) during pre-birth (1 year before pregnancy and pregnancy) and smoke-specific IAP during early life (pregnancy and first year) had significantly impacts on childhood DPA. Furthermore, dampness-specific allergens throughout lifetime elevated the risk of DPA, with ORs ranging from 1.34 (1.00–1.81) to 1.93 (1.44–2.59). Moreover, life-time and early-life antibiotic use significantly increased the DPA risk attributed to some specific IEFs, such as ETS especially grandparental smoking, exposure during first year and previous year, with a significant interaction. Conclusions Life-time and early-life exposure to antibiotics and IEFs independently and jointly played key roles in the development of DPA, supporting the “fetal origin of childhood PA” hypothesis.
Graphical abstract Display Omitted
Highlights Life-time and early-life antibiotic use increased the risk of childhood plant allergy (PA). Renovation-specific indoor air pollution (IAP) exposure before birth elevated the risk of PA. Smoke-specific IAP exposure during early life was associated with increased risk of PA. Dampness-specific indoor allergens exposure throughout lifetime was related with PA risk. Antibiotic use significantly increased childhood PA risk attributed to smoke-specific IAP.
Interaction of life-time and early-life exposure to antibiotics and indoor environmental factors on childhood plant allergy
https://orcid.org/0000-0002-0110-9492
https://orcid.org/0000-0002-2945-4685
Abstract Background Doctor-diagnosed plant allergy (DPA) in children has emerged as a significant global public health concern. However, the role of antibiotics and indoor environmental factors (IEFs) in childhood DPA remains unknown. Objective To investigate the correlations between childhood DPA and exposure to antibiotics and IEFs during different time periods. Methods A retrospective cohort study of 8,689 preschoolers was performed in Changsha, China. We collected data on each child's health outcomes, antibiotics use and home environment by a questionnaire, as well as temperature and air pollutants in Changsha, and calculated personal exposure to temperature and pollutants. Multiple logistic regression models were used to assess the independent and joint effects of antibiotics and IEFs on childhood DPA. Results Life-time and early-life antibiotics use was associated with childhood DPA with ORs (95% CI) = 1.58 (1.15–2.17) and 1.33 (1.04–1.69), with a higher risk for early-life exposure than later-life exposure. Renovation-specific indoor air pollution (IAP) during pre-birth (1 year before pregnancy and pregnancy) and smoke-specific IAP during early life (pregnancy and first year) had significantly impacts on childhood DPA. Furthermore, dampness-specific allergens throughout lifetime elevated the risk of DPA, with ORs ranging from 1.34 (1.00–1.81) to 1.93 (1.44–2.59). Moreover, life-time and early-life antibiotic use significantly increased the DPA risk attributed to some specific IEFs, such as ETS especially grandparental smoking, exposure during first year and previous year, with a significant interaction. Conclusions Life-time and early-life exposure to antibiotics and IEFs independently and jointly played key roles in the development of DPA, supporting the “fetal origin of childhood PA” hypothesis.
Graphical abstract Display Omitted
Highlights Life-time and early-life antibiotic use increased the risk of childhood plant allergy (PA). Renovation-specific indoor air pollution (IAP) exposure before birth elevated the risk of PA. Smoke-specific IAP exposure during early life was associated with increased risk of PA. Dampness-specific indoor allergens exposure throughout lifetime was related with PA risk. Antibiotic use significantly increased childhood PA risk attributed to smoke-specific IAP.
Interaction of life-time and early-life exposure to antibiotics and indoor environmental factors on childhood plant allergy
Lu, Chan (Autor:in) / Lan, Mengju (Autor:in) / Wang, Lin (Autor:in) / Jiang, Ying (Autor:in) / Li, Bin (Autor:in) / Wang, Faming (Autor:in)
Building and Environment ; 254
10.03.2024
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Multiple environmental exposures in early-life and allergy-related outcomes in childhood
| DOAJ | 2020