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Development of a novel ‘nanocarrier’ system based on Halloysite Nanotubes to overcome the complexation of ciprofloxacin with iron: An in vitro approach
AbstractThe bioavailability of ciprofloxacin (CIP) is known to decrease upon administration due to its complexation with iron present in the body. A possible way to prevent this complexation is by entrapping the drug in a carrier. In this study, Halloysite Nanotubes (HNT) post functionalization with 3-aminopropyltriethoxysilane (APTES) were used as ‘nanocarrier’ for the entrapment of CIP. The complexation studies between CIP and iron revealed 71%±1.2% decrease in drug's absorbance upon complexation. Further, the in vitro antibacterial studies also exhibited a reduction in the antibacterial property of CIP on complexation with iron. Pristine HNT exhibited no interaction with CIP and iron. But post functionalization, the nanotubes had a strong interaction with iron and removed 80%±0.9% of it from the solution. Drug loading studies using functionalized HNT (fHNT) presented a 70%±1.7% loading of CIP on it. The samples of HNT (before and after functionalization and after drug loading) were characterized with TEM, XRD, FTIR and DSC. The drug release studies exhibited a sustained release of CIP from drug loaded fHNT. Further, drug loaded fHNT (CIP-fHNT) removed iron from the iron-rich solution and released the loaded drug back into the solution.
Graphical abstract
HighlightsfHNT entrap CIP to avoid its complexation with Fe.71.7%±1.2% reduction in CIP's absorbance upon complexation.Antibacterial studies indicated complexation's effect on drug.NH2 groups on fHNT prevented CIP's complexation with Fe.
Development of a novel ‘nanocarrier’ system based on Halloysite Nanotubes to overcome the complexation of ciprofloxacin with iron: An in vitro approach
AbstractThe bioavailability of ciprofloxacin (CIP) is known to decrease upon administration due to its complexation with iron present in the body. A possible way to prevent this complexation is by entrapping the drug in a carrier. In this study, Halloysite Nanotubes (HNT) post functionalization with 3-aminopropyltriethoxysilane (APTES) were used as ‘nanocarrier’ for the entrapment of CIP. The complexation studies between CIP and iron revealed 71%±1.2% decrease in drug's absorbance upon complexation. Further, the in vitro antibacterial studies also exhibited a reduction in the antibacterial property of CIP on complexation with iron. Pristine HNT exhibited no interaction with CIP and iron. But post functionalization, the nanotubes had a strong interaction with iron and removed 80%±0.9% of it from the solution. Drug loading studies using functionalized HNT (fHNT) presented a 70%±1.7% loading of CIP on it. The samples of HNT (before and after functionalization and after drug loading) were characterized with TEM, XRD, FTIR and DSC. The drug release studies exhibited a sustained release of CIP from drug loaded fHNT. Further, drug loaded fHNT (CIP-fHNT) removed iron from the iron-rich solution and released the loaded drug back into the solution.
Graphical abstract
HighlightsfHNT entrap CIP to avoid its complexation with Fe.71.7%±1.2% reduction in CIP's absorbance upon complexation.Antibacterial studies indicated complexation's effect on drug.NH2 groups on fHNT prevented CIP's complexation with Fe.
Development of a novel ‘nanocarrier’ system based on Halloysite Nanotubes to overcome the complexation of ciprofloxacin with iron: An in vitro approach
Rawtani, Deepak (Autor:in) / Pandey, Gaurav (Autor:in) / Tharmavaram, Maithri (Autor:in) / Pathak, Pooja (Autor:in) / Akkireddy, Satyaprasad (Autor:in) / Agrawal, Y.K. (Autor:in)
Applied Clay Science ; 150 ; 293-302
03.10.2017
10 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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