Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy
https://orcid.org/0000-0003-3979-7443
Abstract Background Biobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited. Objective To describe the within- and between-person variations in serum concentrations of non-persistent chemicals and changes over trimesters, including phthalate metabolites, parabens, phenols, and UV filters. Design Longitudinal study with repeated blood samples from 128 healthy pregnant women during pregnancy. Setting Population based study at a University Hospital in Copenhagen 1999–2001. Methods 503 repetitive prenatal serum samples from 128 pregnant women taken at approximately gestational week 12, 20, 30 and 40 were analyzed for 7 UV filters, 32 metabolites of 15 phthalate diesters, 8 phenols and 7 parabens by LC-MS/MS. Results Ten of 32 phthalate metabolites from six out of 15 phthalate diesters, two of seven parabens, two of eight phenols and three of seven UV filters were measurable in more than half of the serum samples. Of these chemicals, mono‑ethyl phthalate (MEP), mono‑iso‑nonyl phthalate (MiNP), mono‑iso‑decyl phthalate (MiDP), 4‑methylbenzophenone (4‑MBP), 4‑hydroxybenzoephenone (4‑HBP) and n‑propyl paraben (nPrP) had intra-class correlation coefficients (ICC) above 0.4 in both adjusted and unadjusted analyses (0.427–0.795), indicating low within-person variation. The serum concentration of UV filters 4‑MBP and 4‑HBP significantly increased throughout pregnancy, also after adjusting for seasonal variation (4‑HBP: effect estimates 0.142–0.437, p < 0.001. 4‑MBP: effect estimates 0.156–0.458, p < 0.002.). Conclusion MEP, MiNP, MiDP, 4‑MBP, 4‑HBP and nPrP were measurable in >50% of serum samples and showed low within-person variation. Thus, it is possible with acceptable accuracy to evaluate maternal exposure during pregnancy for these non-persistent chemicals using one or more biobank serum samples. The here presented adjusted ICC values can in addition be applied as adjustment of residual variation in future studies that evaluate outcomes related to prenatal exposures.
Highlights Historical mother-child cohorts have serum stored. This study includes serum measurements of phthalates, parabens, phenols and UV filters. Evaluating maternal exposure is possible for some non-persistent chemicals using serum samples. Our study further presents adjusted ICC values which can be applied as adjustment of residual variation.
Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy
https://orcid.org/0000-0003-3979-7443
Abstract Background Biobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited. Objective To describe the within- and between-person variations in serum concentrations of non-persistent chemicals and changes over trimesters, including phthalate metabolites, parabens, phenols, and UV filters. Design Longitudinal study with repeated blood samples from 128 healthy pregnant women during pregnancy. Setting Population based study at a University Hospital in Copenhagen 1999–2001. Methods 503 repetitive prenatal serum samples from 128 pregnant women taken at approximately gestational week 12, 20, 30 and 40 were analyzed for 7 UV filters, 32 metabolites of 15 phthalate diesters, 8 phenols and 7 parabens by LC-MS/MS. Results Ten of 32 phthalate metabolites from six out of 15 phthalate diesters, two of seven parabens, two of eight phenols and three of seven UV filters were measurable in more than half of the serum samples. Of these chemicals, mono‑ethyl phthalate (MEP), mono‑iso‑nonyl phthalate (MiNP), mono‑iso‑decyl phthalate (MiDP), 4‑methylbenzophenone (4‑MBP), 4‑hydroxybenzoephenone (4‑HBP) and n‑propyl paraben (nPrP) had intra-class correlation coefficients (ICC) above 0.4 in both adjusted and unadjusted analyses (0.427–0.795), indicating low within-person variation. The serum concentration of UV filters 4‑MBP and 4‑HBP significantly increased throughout pregnancy, also after adjusting for seasonal variation (4‑HBP: effect estimates 0.142–0.437, p < 0.001. 4‑MBP: effect estimates 0.156–0.458, p < 0.002.). Conclusion MEP, MiNP, MiDP, 4‑MBP, 4‑HBP and nPrP were measurable in >50% of serum samples and showed low within-person variation. Thus, it is possible with acceptable accuracy to evaluate maternal exposure during pregnancy for these non-persistent chemicals using one or more biobank serum samples. The here presented adjusted ICC values can in addition be applied as adjustment of residual variation in future studies that evaluate outcomes related to prenatal exposures.
Highlights Historical mother-child cohorts have serum stored. This study includes serum measurements of phthalates, parabens, phenols and UV filters. Evaluating maternal exposure is possible for some non-persistent chemicals using serum samples. Our study further presents adjusted ICC values which can be applied as adjustment of residual variation.
Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy
https://orcid.org/0000-0003-3979-7443
Abstract Background Biobank serum samples from longitudinal mother-child cohorts have been used to estimate prenatal exposures to endocrine disrupting chemicals (EDCs). However, the knowledge about variations in serum concentrations of non-persistent chemicals during pregnancy is limited. Objective To describe the within- and between-person variations in serum concentrations of non-persistent chemicals and changes over trimesters, including phthalate metabolites, parabens, phenols, and UV filters. Design Longitudinal study with repeated blood samples from 128 healthy pregnant women during pregnancy. Setting Population based study at a University Hospital in Copenhagen 1999–2001. Methods 503 repetitive prenatal serum samples from 128 pregnant women taken at approximately gestational week 12, 20, 30 and 40 were analyzed for 7 UV filters, 32 metabolites of 15 phthalate diesters, 8 phenols and 7 parabens by LC-MS/MS. Results Ten of 32 phthalate metabolites from six out of 15 phthalate diesters, two of seven parabens, two of eight phenols and three of seven UV filters were measurable in more than half of the serum samples. Of these chemicals, mono‑ethyl phthalate (MEP), mono‑iso‑nonyl phthalate (MiNP), mono‑iso‑decyl phthalate (MiDP), 4‑methylbenzophenone (4‑MBP), 4‑hydroxybenzoephenone (4‑HBP) and n‑propyl paraben (nPrP) had intra-class correlation coefficients (ICC) above 0.4 in both adjusted and unadjusted analyses (0.427–0.795), indicating low within-person variation. The serum concentration of UV filters 4‑MBP and 4‑HBP significantly increased throughout pregnancy, also after adjusting for seasonal variation (4‑HBP: effect estimates 0.142–0.437, p < 0.001. 4‑MBP: effect estimates 0.156–0.458, p < 0.002.). Conclusion MEP, MiNP, MiDP, 4‑MBP, 4‑HBP and nPrP were measurable in >50% of serum samples and showed low within-person variation. Thus, it is possible with acceptable accuracy to evaluate maternal exposure during pregnancy for these non-persistent chemicals using one or more biobank serum samples. The here presented adjusted ICC values can in addition be applied as adjustment of residual variation in future studies that evaluate outcomes related to prenatal exposures.
Highlights Historical mother-child cohorts have serum stored. This study includes serum measurements of phthalates, parabens, phenols and UV filters. Evaluating maternal exposure is possible for some non-persistent chemicals using serum samples. Our study further presents adjusted ICC values which can be applied as adjustment of residual variation.
Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy
Assens, Maria (Autor:in) / Frederiksen, Hanne (Autor:in) / Petersen, Jørgen Holm (Autor:in) / Larsen, Torben (Autor:in) / Skakkebæk, Niels E. (Autor:in) / Juul, Anders (Autor:in) / Andersson, Anna-Maria (Autor:in) / Main, Katharina M. (Autor:in)
Environmental International ; 123 ; 318-324
19.11.2018
7 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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Presence of parabens, phenols and phthalates in paired maternal serum, urine and amniotic fluid
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