Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort
Abstract Background Numerous cross-sectional studies of school-age children have observed that exposure to manganese (Mn) adversely affects neurodevelopment. However, few prospective studies have looked at the effects of both prenatal and postnatal Mn exposure on child neurodevelopment. Methods We measured Mn levels in prenatal and early postnatal dentine of shed teeth and examined their association with behavior, cognition, memory, and motor functioning in 248 children aged 7, 9, and/or 10.5years living near agricultural fields treated with Mn-containing fungicides in California. We used generalized linear models and generalized additive models to test for linear and nonlinear associations, and generalized estimating equation models to assess longitudinal effects. Results We observed that higher prenatal and early postnatal Mn levels in dentine of deciduous teeth were adversely associated with behavioral outcomes, namely internalizing, externalizing, and hyperactivity problems, in boys and girls at 7 and 10.5years. In contrast, higher Mn levels in prenatal and postnatal dentine were associated with better memory abilities at ages 9 and 10.5, and better cognitive and motor outcomes at ages 7 and 10.5years, among boys only. Higher prenatal dentine Mn levels were also associated with poorer visuospatial memory outcomes at 9years and worse cognitive scores at 7 and 10.5years in children with higher prenatal lead levels (≥0.8μg/dL). All these associations were linear and were consistent with findings from longitudinal analyses. Conclusions We observed that higher prenatal and early postnatal Mn levels measured in dentine of deciduous teeth, a novel biomarker that provides reliable information on the developmental timing of exposures to Mn, were associated with poorer behavioral outcomes in school-age boys and girls and better motor function, memory, and/or cognitive abilities in school-age boys. Additional research is needed to understand the inconsistencies in the neurodevelopmental findings across studies and the degree to which differences may be associated with different Mn exposure pathways and biomarkers.
Highlights Measured prenatal and postnatal Mn in dentine of deciduous teeth Assessed neurodevelopment in children at ages 7, 9, and 10.5years Higher Mn associated with poorer behavioral outcomes Higher Mn associated with better memory, cognitive, and motor abilities in boys Not statistically significant but notable interaction between prenatal Mn and lead
Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort
Abstract Background Numerous cross-sectional studies of school-age children have observed that exposure to manganese (Mn) adversely affects neurodevelopment. However, few prospective studies have looked at the effects of both prenatal and postnatal Mn exposure on child neurodevelopment. Methods We measured Mn levels in prenatal and early postnatal dentine of shed teeth and examined their association with behavior, cognition, memory, and motor functioning in 248 children aged 7, 9, and/or 10.5years living near agricultural fields treated with Mn-containing fungicides in California. We used generalized linear models and generalized additive models to test for linear and nonlinear associations, and generalized estimating equation models to assess longitudinal effects. Results We observed that higher prenatal and early postnatal Mn levels in dentine of deciduous teeth were adversely associated with behavioral outcomes, namely internalizing, externalizing, and hyperactivity problems, in boys and girls at 7 and 10.5years. In contrast, higher Mn levels in prenatal and postnatal dentine were associated with better memory abilities at ages 9 and 10.5, and better cognitive and motor outcomes at ages 7 and 10.5years, among boys only. Higher prenatal dentine Mn levels were also associated with poorer visuospatial memory outcomes at 9years and worse cognitive scores at 7 and 10.5years in children with higher prenatal lead levels (≥0.8μg/dL). All these associations were linear and were consistent with findings from longitudinal analyses. Conclusions We observed that higher prenatal and early postnatal Mn levels measured in dentine of deciduous teeth, a novel biomarker that provides reliable information on the developmental timing of exposures to Mn, were associated with poorer behavioral outcomes in school-age boys and girls and better motor function, memory, and/or cognitive abilities in school-age boys. Additional research is needed to understand the inconsistencies in the neurodevelopmental findings across studies and the degree to which differences may be associated with different Mn exposure pathways and biomarkers.
Highlights Measured prenatal and postnatal Mn in dentine of deciduous teeth Assessed neurodevelopment in children at ages 7, 9, and 10.5years Higher Mn associated with poorer behavioral outcomes Higher Mn associated with better memory, cognitive, and motor abilities in boys Not statistically significant but notable interaction between prenatal Mn and lead
Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort
Mora, Ana M. (Autor:in) / Arora, Manish (Autor:in) / Harley, Kim G. (Autor:in) / Kogut, Katherine (Autor:in) / Parra, Kimberly (Autor:in) / Hernández-Bonilla, David (Autor:in) / Gunier, Robert B. (Autor:in) / Bradman, Asa (Autor:in) / Smith, Donald R. (Autor:in) / Eskenazi, Brenda (Autor:in)
Environmental International ; 84 ; 39-54
05.07.2015
16 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
ADHD , Attention Deficit Hyperactivity Disorder , AUC , Area Under the Curve , BASC-2 , Behavior Assessment Scale for Children, 2nd edition , CADS , Conners' ADHD/DSM-IV Scales, Parent and Teacher versions , CAVLT-2 , Children's Auditory Verbal Learning Test, 2nd edition , CES-D , Center for Epidemiologic Studies Depression Scale , CHAM1 , Initial CHAMACOS cohort (recruited 1999–2000 during pregnancy) , CHAM2 , Second CHAMACOS cohort (recruited 2009–2011 at child age 9) , CHAMACOS , Center for the Health Assessment of Mothers and Children of Salinas , CI , Confidence Interval , CPT-II , Conners' Continuous Performance Test II, Version 5 , DAP , Dialkyl Phosphate , DSM-IV , Diagnostic and Statistical Manual of Mental Disorders, 4th edition , GEE , Generalized Estimating Equations , GM , Geometric Mean , HOME , Home Observation for Measurement of the Environment , IQ , Intelligence Quotient , LOD , Limit of Detection , Mn , Manganese , NEPSY-II , A Developmental Neuropsychological Assessment, 2nd edition , OP , Organophosphate , PBDE , Polybrominated Diphenyl Ether , PPVT , Peabody Picture Vocabulary Test , TVIP , Test de Vocabulario en Imágenes Peabody , SD , Standard Deviation , SE , Standard Error , WISC-IV , Wechsler Intelligence Scale for Children, 4th edition , WRAVMA , Wide Range Assessment of Visual Motor Ability , Teeth , Neurodevelopment , Children , California
Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort
| Elsevier | 2015
Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort
| Online Contents | 2015
| British Library Online Contents | 2004