Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Preparation method of sintering-free porous apatite composite scaffold
The invention discloses a preparation method of a sintering-free porous apatite composite scaffold, and the method specifically comprises the following steps: preparing coating fibers, and then carrying out hydrothermal treatment on the coating fibers; preparing a freezing medium solution; uniformly dispersing the coating fibers in the freezing medium solution to obtain turbid liquid; mixing solid-phase powder tetracalcium phosphate TTCP with dicalcium phosphate dihydrate DCPD or anhydrous dicalcium phosphate DCPA according to a certain proportion, then mixing with the turbid liquid, and then carrying out uniform ball milling to obtain stable slurry; injecting the stable slurry into a freeze-drying mold for directional freezing and vacuum drying to obtain a solid-phase composite scaffold; soaking the solid-phase composite scaffold in a Na2HPO4 liquid phase with a certain concentration for a liquid-phase impregnation reaction, and performing maintaining in simulated body fluid SBF to form the porous apatite composite scaffold. The problems that in the prior art, biological compatibility and mechanical compatibility of a porous apatite support are difficult to achieve at the same time, and a fiber reinforced phase is prone to being pulled out when stressed are solved.
本发明公开了一种免烧结多孔磷灰石复合支架的制备方法，具体为：制备涂层纤维，然后对涂层纤维进行水热处理；配置冷冻介质溶液；将涂层纤维均匀分散冷冻介质溶液之中，得到悬浊液；将固相粉磷酸四钙TTCP与二水合磷酸氢钙DCPD或者无水磷酸氢钙DCPA以一定比例混合后与悬浊液混合，然后球磨均匀后得到稳定浆料；将稳定浆料注入冻干模具中定向冷冻，真空干燥，得到固相复合支架；将固相复合支架浸泡在一定浓度的Na2HPO4液相进行液相浸渍反应后在模拟体液SBF中养护形成多孔磷灰石复合支架。本发明解决了现有技术中存在的多孔磷灰石支架的生物与力学相容性难以兼备以及纤维增强相受力易拔出的问题。
Preparation method of sintering-free porous apatite composite scaffold
The invention discloses a preparation method of a sintering-free porous apatite composite scaffold, and the method specifically comprises the following steps: preparing coating fibers, and then carrying out hydrothermal treatment on the coating fibers; preparing a freezing medium solution; uniformly dispersing the coating fibers in the freezing medium solution to obtain turbid liquid; mixing solid-phase powder tetracalcium phosphate TTCP with dicalcium phosphate dihydrate DCPD or anhydrous dicalcium phosphate DCPA according to a certain proportion, then mixing with the turbid liquid, and then carrying out uniform ball milling to obtain stable slurry; injecting the stable slurry into a freeze-drying mold for directional freezing and vacuum drying to obtain a solid-phase composite scaffold; soaking the solid-phase composite scaffold in a Na2HPO4 liquid phase with a certain concentration for a liquid-phase impregnation reaction, and performing maintaining in simulated body fluid SBF to form the porous apatite composite scaffold. The problems that in the prior art, biological compatibility and mechanical compatibility of a porous apatite support are difficult to achieve at the same time, and a fiber reinforced phase is prone to being pulled out when stressed are solved.
本发明公开了一种免烧结多孔磷灰石复合支架的制备方法，具体为：制备涂层纤维，然后对涂层纤维进行水热处理；配置冷冻介质溶液；将涂层纤维均匀分散冷冻介质溶液之中，得到悬浊液；将固相粉磷酸四钙TTCP与二水合磷酸氢钙DCPD或者无水磷酸氢钙DCPA以一定比例混合后与悬浊液混合，然后球磨均匀后得到稳定浆料；将稳定浆料注入冻干模具中定向冷冻，真空干燥，得到固相复合支架；将固相复合支架浸泡在一定浓度的Na2HPO4液相进行液相浸渍反应后在模拟体液SBF中养护形成多孔磷灰石复合支架。本发明解决了现有技术中存在的多孔磷灰石支架的生物与力学相容性难以兼备以及纤维增强相受力易拔出的问题。
Preparation method of sintering-free porous apatite composite scaffold
一种免烧结多孔磷灰石复合支架的制备方法
TANG YUFEI (Autor:in) / ZHOU XUAN (Autor:in) / ZHAO KANG (Autor:in) / WU CONG (Autor:in) / SONG YUTING (Autor:in)
10.08.2021
Patent
Elektronische Ressource
Chinesisch
IPC:
C04B
Kalk
,
LIME
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