Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Controllable porous calcium phosphate scaffold and preparation method thereof
The invention relates to a controllable porous calcium phosphate scaffold and a preparation method thereof. The calcium phosphate scaffold comprises calcium phosphate ceramic and calcium phosphate bone cement, the calcium phosphate scaffold is provided with a pore structure, the pore structure comprises a macro-pore structure, a micro-pore structure and a through-pore structure, and the calcium phosphate scaffold comprises crystal structures; and a through hole structure is arranged between the crystal structures, and the shape of the calcium phosphate stent is matched and designed according to the defect part of a patient. The preparation method of the sacrificial material is improved, a 3D printing technology with higher precision is selected, and more complex and diversified pore structures can be prepared; the prepared stent is provided with controllable micropores and through holes among crystals of the stent, the degradation rate of the stent is changed by controlling the pore structure, meanwhile, the ingrowth rate and ingrowth volume of new bones and blood vessels are affected by the pore structure, and therefore the biological activity and osteogenesis of the bone implantation stent are further improved; and the technological process is simple and easy to operate, and the prepared scaffold is stable in structural performance, high in compressive strength and good in cell compatibility.
本发明涉及一种可控多孔磷酸钙支架及其制备方法，所述磷酸钙支架的成分包括钙磷陶瓷和磷酸钙骨水泥，所述磷酸钙支架上设置有孔结构，所述孔结构包括宏孔结构、微孔结构和通孔结构，所述磷酸钙支架包括晶体结构，所述晶体结构之间设置有通孔结构，所述磷酸钙支架的外形根据患者缺损部位进行匹配设计。本发明改进了牺牲材料的制备方法，选用精度更高的3D打印技术，可以制备出更加复杂多样的孔结构；本发明制备的支架具备可控的微孔和支架本身晶体间的贯通孔，控制孔结构进而改变支架降解速率，同时孔结构又影响新生骨和血管的长入速率和长入体积，所以进一步提升骨植入支架的生物活性和成骨性；本发明工艺流程简单易操作，制备的支架结构性能稳定，抗压强度大，具有良好的细胞相容性。
Controllable porous calcium phosphate scaffold and preparation method thereof
The invention relates to a controllable porous calcium phosphate scaffold and a preparation method thereof. The calcium phosphate scaffold comprises calcium phosphate ceramic and calcium phosphate bone cement, the calcium phosphate scaffold is provided with a pore structure, the pore structure comprises a macro-pore structure, a micro-pore structure and a through-pore structure, and the calcium phosphate scaffold comprises crystal structures; and a through hole structure is arranged between the crystal structures, and the shape of the calcium phosphate stent is matched and designed according to the defect part of a patient. The preparation method of the sacrificial material is improved, a 3D printing technology with higher precision is selected, and more complex and diversified pore structures can be prepared; the prepared stent is provided with controllable micropores and through holes among crystals of the stent, the degradation rate of the stent is changed by controlling the pore structure, meanwhile, the ingrowth rate and ingrowth volume of new bones and blood vessels are affected by the pore structure, and therefore the biological activity and osteogenesis of the bone implantation stent are further improved; and the technological process is simple and easy to operate, and the prepared scaffold is stable in structural performance, high in compressive strength and good in cell compatibility.
本发明涉及一种可控多孔磷酸钙支架及其制备方法，所述磷酸钙支架的成分包括钙磷陶瓷和磷酸钙骨水泥，所述磷酸钙支架上设置有孔结构，所述孔结构包括宏孔结构、微孔结构和通孔结构，所述磷酸钙支架包括晶体结构，所述晶体结构之间设置有通孔结构，所述磷酸钙支架的外形根据患者缺损部位进行匹配设计。本发明改进了牺牲材料的制备方法，选用精度更高的3D打印技术，可以制备出更加复杂多样的孔结构；本发明制备的支架具备可控的微孔和支架本身晶体间的贯通孔，控制孔结构进而改变支架降解速率，同时孔结构又影响新生骨和血管的长入速率和长入体积，所以进一步提升骨植入支架的生物活性和成骨性；本发明工艺流程简单易操作，制备的支架结构性能稳定，抗压强度大，具有良好的细胞相容性。
Controllable porous calcium phosphate scaffold and preparation method thereof
一种可控多孔磷酸钙支架及其制备方法
GUO LIKUN (Autor:in) / JIA HENGXING (Autor:in) / ZHU XIANGDONG (Autor:in) / FAN YUJIANG (Autor:in) / ZHANG XINGDONG (Autor:in)
10.08.2021
Patent
Elektronische Ressource
Chinesisch
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