Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Methacryloylated gelatin/biological ceramic paste and forming and printing method
The invention provides a preparation method and application of methacrylated gelatin/biological ceramic paste suitable for an SLA technology. According to the paste material, methacrylic acid gelatin is used as a prepolymer, biological ceramic powder is loaded, the formula is simple, and the components are all medical-grade components. The biological ceramic formed by SLA printing has a controllable microscopic aperture and a personalized appearance structure. In addition, the microporous structure is similar to a cancellous bone structure in natural bone tissue, so that the material can be used for repairing bone defects. Degreasing and sintering are not needed after photocuring forming, biological ceramic crystal grains in a formed part can keep the original shape and size, and the biological activity is high. The biological ceramic/methacrylated gelatin paste prepared by the invention is mild in forming condition, can carry bioactive factors, does not influence the activity of the bioactive factors due to process problems, and can further improve the osteoinductivity of the material.
本发明提供一种适用于SLA技术的甲基丙烯酰化明胶/生物陶瓷膏料的制备方法及应用。该膏料以甲基丙烯酸化明胶为预聚物，负载生物陶瓷粉末，配方简单，成分均为医用级。经SLA打印成形的生物陶瓷具有可控的微观孔径和个性化的外形结构。并且，微孔结构与天然骨组织中的松质骨结构类似，可以用于骨缺陷的修复。光固化成形后无需脱脂烧结，成形件中的生物陶瓷晶粒可以保持原始的形状尺寸，生物活性高。本发明制备的生物陶瓷/甲基丙烯酰化明胶膏料成形条件温和，可以搭载生物活性因子，并且不会因工艺问题影响生物活性因子的活性，可进一步提高材料的骨诱导性。
Methacryloylated gelatin/biological ceramic paste and forming and printing method
The invention provides a preparation method and application of methacrylated gelatin/biological ceramic paste suitable for an SLA technology. According to the paste material, methacrylic acid gelatin is used as a prepolymer, biological ceramic powder is loaded, the formula is simple, and the components are all medical-grade components. The biological ceramic formed by SLA printing has a controllable microscopic aperture and a personalized appearance structure. In addition, the microporous structure is similar to a cancellous bone structure in natural bone tissue, so that the material can be used for repairing bone defects. Degreasing and sintering are not needed after photocuring forming, biological ceramic crystal grains in a formed part can keep the original shape and size, and the biological activity is high. The biological ceramic/methacrylated gelatin paste prepared by the invention is mild in forming condition, can carry bioactive factors, does not influence the activity of the bioactive factors due to process problems, and can further improve the osteoinductivity of the material.
本发明提供一种适用于SLA技术的甲基丙烯酰化明胶/生物陶瓷膏料的制备方法及应用。该膏料以甲基丙烯酸化明胶为预聚物，负载生物陶瓷粉末，配方简单，成分均为医用级。经SLA打印成形的生物陶瓷具有可控的微观孔径和个性化的外形结构。并且，微孔结构与天然骨组织中的松质骨结构类似，可以用于骨缺陷的修复。光固化成形后无需脱脂烧结，成形件中的生物陶瓷晶粒可以保持原始的形状尺寸，生物活性高。本发明制备的生物陶瓷/甲基丙烯酰化明胶膏料成形条件温和，可以搭载生物活性因子，并且不会因工艺问题影响生物活性因子的活性，可进一步提高材料的骨诱导性。
Methacryloylated gelatin/biological ceramic paste and forming and printing method
一种甲基丙烯酰化明胶/生物陶瓷膏料及成形打印方法
ZOU BIN (Autor:in) / CHEN QINGHUA (Autor:in) / LAI QINGGUO (Autor:in) / HUANG CHUANZHEN (Autor:in)
13.05.2022
Patent
Elektronische Ressource
Chinesisch
IPC:
C04B
Kalk
,
LIME
/
B29C
Formen oder Verbinden von Kunststoffen
,
SHAPING OR JOINING OF PLASTICS
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
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