Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Preparation method of calcium phosphate ceramic for drug loading and drug loading method
The invention discloses a preparation method of calcium phosphate ceramic for drug loading and a drug loading method, and the preparation method comprises the following steps: step 1, placing porous calcium phosphate ceramic in a hydrothermal medium formed by a phosphorus-containing organic salt or inorganic salt solution, and after the hydrothermal reaction is sufficient, washing and drying to obtain calcium phosphate ceramic with a hollow tube structure; and step 2, placing the calcium phosphate ceramic with the hollow tube structure obtained in the step 1 in a gel solution, adding a cross-linking agent, vacuumizing and carrying out a gel reaction, and obtaining the required calcium phosphate ceramic after gel formation, the calcium phosphate ceramic with the long-acting antibiotic release function is obtained through specific hydro-thermal treatment, antibiotic adsorption and gel coating, and the calcium phosphate ceramic with the long-acting antibiotic release function not only has the long-acting antibiotic release function, but also has good bone induction capacity and can meet the requirements of clinical infectious bone defect regeneration and repair.
本发明公开了一种用于载药的磷酸钙陶瓷制备方法和载药方法，包括以下步骤：步骤1：将多孔磷酸钙陶瓷置于含磷有机盐或无机盐溶液形成的水热介质中，水热反应充分后，洗涤、烘干得到具有中空管结构的磷酸钙陶瓷；步骤2：将步骤1中得到的具有中空管结构的磷酸钙陶瓷置于凝胶溶液中，加入交联剂，抽真空进行凝胶反应，成胶后即可得到所需磷酸钙陶瓷；本发明通过特定水热处理、吸附抗生素和包覆凝胶后即得到具有长效释放抗生素的磷酸钙陶瓷，具有长效释放抗生素的磷酸钙陶瓷不仅具有长效释放抗生素能力，而且具有较好的骨诱导能力，可以满足临床感染性骨缺损再生修复的要求。
Preparation method of calcium phosphate ceramic for drug loading and drug loading method
The invention discloses a preparation method of calcium phosphate ceramic for drug loading and a drug loading method, and the preparation method comprises the following steps: step 1, placing porous calcium phosphate ceramic in a hydrothermal medium formed by a phosphorus-containing organic salt or inorganic salt solution, and after the hydrothermal reaction is sufficient, washing and drying to obtain calcium phosphate ceramic with a hollow tube structure; and step 2, placing the calcium phosphate ceramic with the hollow tube structure obtained in the step 1 in a gel solution, adding a cross-linking agent, vacuumizing and carrying out a gel reaction, and obtaining the required calcium phosphate ceramic after gel formation, the calcium phosphate ceramic with the long-acting antibiotic release function is obtained through specific hydro-thermal treatment, antibiotic adsorption and gel coating, and the calcium phosphate ceramic with the long-acting antibiotic release function not only has the long-acting antibiotic release function, but also has good bone induction capacity and can meet the requirements of clinical infectious bone defect regeneration and repair.
本发明公开了一种用于载药的磷酸钙陶瓷制备方法和载药方法，包括以下步骤：步骤1：将多孔磷酸钙陶瓷置于含磷有机盐或无机盐溶液形成的水热介质中，水热反应充分后，洗涤、烘干得到具有中空管结构的磷酸钙陶瓷；步骤2：将步骤1中得到的具有中空管结构的磷酸钙陶瓷置于凝胶溶液中，加入交联剂，抽真空进行凝胶反应，成胶后即可得到所需磷酸钙陶瓷；本发明通过特定水热处理、吸附抗生素和包覆凝胶后即得到具有长效释放抗生素的磷酸钙陶瓷，具有长效释放抗生素的磷酸钙陶瓷不仅具有长效释放抗生素能力，而且具有较好的骨诱导能力，可以满足临床感染性骨缺损再生修复的要求。
Preparation method of calcium phosphate ceramic for drug loading and drug loading method
一种用于载药的磷酸钙陶瓷制备方法和载药方法
LI XIANGFENG (Autor:in) / FENG CONG (Autor:in) / HE TINGHAN (Autor:in) / ZHU XIANGDONG (Autor:in) / XIAO YUMEI (Autor:in) / ZHANG XINGDONG (Autor:in)
01.11.2022
Patent
Elektronische Ressource
Chinesisch
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