Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Preparation method of hydroxyapatite bone tissue engineering scaffold
The invention relates to the technical field of biomedical materials, in particular to a preparation method of a hydroxyapatite bone tissue engineering scaffold, which comprises the following steps: preparing acetylated or alkylated modified cellulose nanocrystals; synthesizing hydroxyapatite by taking the modified cellulose nanocrystal as a biological dispersing agent; and preparing the bone tissue engineering scaffold from the synthesized hydroxyapatite. The preparation method disclosed by the invention is simple in process, low in experimental condition requirement and free of expensive equipment; meanwhile, no organic surfactant is introduced, and the used dispersing agent is basically harmless to the environment and organisms; the prepared HA has good dispersity; the hydroxyapatite bone tissue engineering scaffold has good biocompatibility, is beneficial to proliferation and differentiation of osteoblasts, and is beneficial to structural remodeling and construction of bone defect tissues.
本发明涉及生物医用材料技术领域，尤其涉及一种羟基磷灰石骨组织工程支架的制备方法，包括如下步骤：制备乙酰化或烷基化的改性纤维素纳米晶；将所述改性纤维素纳米晶作为生物分散剂合成羟基磷灰石；采用合成的所述羟基磷灰石制备得到骨组织工程支架。本发明的制备方法工艺简单，实验条件要求不高，无需昂贵设备；同时不引入有机表面活性剂，所使用的分散剂对环境和生物体基本无害；制备的HA具有良好的分散性；羟基磷灰石骨组织工程支架具有较好的生物相容性，有利于成骨细胞的增殖分化，有利于骨缺损组织的结构重塑和构建。
Preparation method of hydroxyapatite bone tissue engineering scaffold
The invention relates to the technical field of biomedical materials, in particular to a preparation method of a hydroxyapatite bone tissue engineering scaffold, which comprises the following steps: preparing acetylated or alkylated modified cellulose nanocrystals; synthesizing hydroxyapatite by taking the modified cellulose nanocrystal as a biological dispersing agent; and preparing the bone tissue engineering scaffold from the synthesized hydroxyapatite. The preparation method disclosed by the invention is simple in process, low in experimental condition requirement and free of expensive equipment; meanwhile, no organic surfactant is introduced, and the used dispersing agent is basically harmless to the environment and organisms; the prepared HA has good dispersity; the hydroxyapatite bone tissue engineering scaffold has good biocompatibility, is beneficial to proliferation and differentiation of osteoblasts, and is beneficial to structural remodeling and construction of bone defect tissues.
本发明涉及生物医用材料技术领域，尤其涉及一种羟基磷灰石骨组织工程支架的制备方法，包括如下步骤：制备乙酰化或烷基化的改性纤维素纳米晶；将所述改性纤维素纳米晶作为生物分散剂合成羟基磷灰石；采用合成的所述羟基磷灰石制备得到骨组织工程支架。本发明的制备方法工艺简单，实验条件要求不高，无需昂贵设备；同时不引入有机表面活性剂，所使用的分散剂对环境和生物体基本无害；制备的HA具有良好的分散性；羟基磷灰石骨组织工程支架具有较好的生物相容性，有利于成骨细胞的增殖分化，有利于骨缺损组织的结构重塑和构建。
Preparation method of hydroxyapatite bone tissue engineering scaffold
一种羟基磷灰石骨组织工程支架的制备方法
SUN HONGNAN (Autor:in) / MU TAIHUA (Autor:in) / ZHU SHUNSHUN (Autor:in) / MA MENGMEI (Autor:in) / ZHANG MIAO (Autor:in) / HUA FEIGUO (Autor:in)
29.08.2023
Patent
Elektronische Ressource
Chinesisch
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