Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Photocuring 3D printing biological ceramic osteochondral scaffold and preparation method thereof
The invention discloses a photocuring 3D printing biological ceramic bone cartilage scaffold, and relates to the technical field of tissue repair materials, the scaffold comprises a cartilage repair layer and a subchondral bone repair layer which are made of the same material, the cartilage repair layer has a porous structure with a first aperture, the first aperture is 100-1000 [mu] m, the subchondral bone repair layer has a porous structure with a second aperture, and the second aperture is 100-1000 [mu] m. The second aperture is 300-1000 [mu] m, the cartilage repair layer and the lower bone repair layer are mutually staggered at the junction to form a pore structure with a third aperture, and the third aperture is 50-300 [mu] m; the third aperture is smaller than the first aperture and the second aperture. The osteochondral scaffold disclosed by the invention not only can ensure that bone marrow blood carries bioactive substances such as mesenchymal stem cells and growth factors to permeate to a cartilage defect part, but also can prevent blood vessel invasion of a lower bone repair layer and prevent calcification of a cartilage layer; and the lower bone repair layer provides enough support for the repair of the cartilage layer in the repair process.
本申请公开了一种光固化3D打印生物陶瓷骨软骨支架，涉及组织修复材料技术领域，该支架包括由相同材料形成的软骨修复层和软骨下骨修复层，软骨修复层具有第一孔径的多孔结构，第一孔径为100‑1000μm，下骨修复层具有第二孔径的多孔结构，第二孔径为300‑1000μm，软骨修复层与下骨修复层在交界处相互交错形成具有第三孔径的孔隙结构，第三孔径为50‑300μm；第三孔径小于第一孔径和第二孔径。本发明的骨软骨支架既能保证骨髓血携带骨髓间充质干细胞和生长因子等生物活性物质向软骨缺损部位渗透，同时能阻碍下骨修复层的血管侵袭，防止软骨层钙化；下骨修复层在修复过程中对软骨层的修复提供足够的支撑。
Photocuring 3D printing biological ceramic osteochondral scaffold and preparation method thereof
The invention discloses a photocuring 3D printing biological ceramic bone cartilage scaffold, and relates to the technical field of tissue repair materials, the scaffold comprises a cartilage repair layer and a subchondral bone repair layer which are made of the same material, the cartilage repair layer has a porous structure with a first aperture, the first aperture is 100-1000 [mu] m, the subchondral bone repair layer has a porous structure with a second aperture, and the second aperture is 100-1000 [mu] m. The second aperture is 300-1000 [mu] m, the cartilage repair layer and the lower bone repair layer are mutually staggered at the junction to form a pore structure with a third aperture, and the third aperture is 50-300 [mu] m; the third aperture is smaller than the first aperture and the second aperture. The osteochondral scaffold disclosed by the invention not only can ensure that bone marrow blood carries bioactive substances such as mesenchymal stem cells and growth factors to permeate to a cartilage defect part, but also can prevent blood vessel invasion of a lower bone repair layer and prevent calcification of a cartilage layer; and the lower bone repair layer provides enough support for the repair of the cartilage layer in the repair process.
本申请公开了一种光固化3D打印生物陶瓷骨软骨支架，涉及组织修复材料技术领域，该支架包括由相同材料形成的软骨修复层和软骨下骨修复层，软骨修复层具有第一孔径的多孔结构，第一孔径为100‑1000μm，下骨修复层具有第二孔径的多孔结构，第二孔径为300‑1000μm，软骨修复层与下骨修复层在交界处相互交错形成具有第三孔径的孔隙结构，第三孔径为50‑300μm；第三孔径小于第一孔径和第二孔径。本发明的骨软骨支架既能保证骨髓血携带骨髓间充质干细胞和生长因子等生物活性物质向软骨缺损部位渗透，同时能阻碍下骨修复层的血管侵袭，防止软骨层钙化；下骨修复层在修复过程中对软骨层的修复提供足够的支撑。
Photocuring 3D printing biological ceramic osteochondral scaffold and preparation method thereof
光固化3D打印生物陶瓷骨软骨支架及其制备方法
GAO CHEN (Autor:in) / CHEN WEIMING (Autor:in) / LI HANG (Autor:in) / YANG XUXIA (Autor:in)
03.12.2024
Patent
Elektronische Ressource
Chinesisch
IPC:
A61F
FILTERS IMPLANTABLE INTO BLOOD VESSELS
,
Filter in Blutgefäße implantierbar
/
A61L
Verfahren oder Vorrichtungen zum Sterilisieren von Stoffen oder Gegenständen allgemein
,
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
/
B33Y
ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
,
Additive (generative) Fertigung, d. h. die Herstellung von dreidimensionalen [3D] Bauteilen durch additive Abscheidung, additive Agglomeration oder additive Schichtung, z. B. durch 3D- Drucken, Stereolithografie oder selektives Lasersintern
/
C04B
Kalk
,
LIME
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