Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Regional Deposition of Inhaled Nano- to Microscale Particles in Realistic Upper Respiratory Tract Model Under Steady and Transient Breathing Conditions
Inhalation exposure to various types of airborne particles is an important risk factor for human health. This study predicted particle transport and deposition in a realistic human airway model during breathing and observed the effects of steady-state flow and transient flow on the deposition fraction using computational fluid dynamics (CFD). To evaluate the effect of the transient breathing profile on particle transport and deposition in the respiratory tract, we reproduced two unsteady breathing cycles with different breathing time scales. The particle dispersion analysis targeted approximately 50,000 or 75,000 particles, with aerodynamic diameters ranging from 2 nm to 10 µm, randomly placed near the nostril. Under transient breathing conditions, a total of approximately 50,000 or 75,000 particles were continuously released at each time step during the inhalation period. As a result, a significant difference in particle deposition and transport to the lower airway region was confirmed for different breathing patterns.
Regional Deposition of Inhaled Nano- to Microscale Particles in Realistic Upper Respiratory Tract Model Under Steady and Transient Breathing Conditions
Inhalation exposure to various types of airborne particles is an important risk factor for human health. This study predicted particle transport and deposition in a realistic human airway model during breathing and observed the effects of steady-state flow and transient flow on the deposition fraction using computational fluid dynamics (CFD). To evaluate the effect of the transient breathing profile on particle transport and deposition in the respiratory tract, we reproduced two unsteady breathing cycles with different breathing time scales. The particle dispersion analysis targeted approximately 50,000 or 75,000 particles, with aerodynamic diameters ranging from 2 nm to 10 µm, randomly placed near the nostril. Under transient breathing conditions, a total of approximately 50,000 or 75,000 particles were continuously released at each time step during the inhalation period. As a result, a significant difference in particle deposition and transport to the lower airway region was confirmed for different breathing patterns.
Regional Deposition of Inhaled Nano- to Microscale Particles in Realistic Upper Respiratory Tract Model Under Steady and Transient Breathing Conditions
Environ Sci Eng
Wang, Liangzhu Leon (Herausgeber:in) / Ge, Hua (Herausgeber:in) / Zhai, Zhiqiang John (Herausgeber:in) / Qi, Dahai (Herausgeber:in) / Ouf, Mohamed (Herausgeber:in) / Sun, Chanjuan (Herausgeber:in) / Wang, Dengjia (Herausgeber:in) / Kizuka, Ryusei (Autor:in) / Kuga, Kazuki (Autor:in) / Ito, Kazuhide (Autor:in)
International Conference on Building Energy and Environment ; 2022
Proceedings of the 5th International Conference on Building Energy and Environment ; Kapitel: 173 ; 1673-1676
05.09.2023
4 pages
Aufsatz/Kapitel (Buch)
Elektronische Ressource
Englisch
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