Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Mercury Toxicity and Neurodegenerative Effects
Neurodegeneration is a broadly defined term that describes the loss of neuronal structure and function, and produces disorders known as neurodegenerative diseases. A common feature of neurodegeneration is the progressive cell loss in specific neuronal populations of the central nervous system (CNS), often associated with cytoskeletal protein changes that led to intracytoplasmic and/or intranuclear inclusions in neurons and/or glia. The neurological consequences of neurodegeneration in patients are often devastating and result in severe mental and physical effects, accounting for a large number of hospitalizations and disabilities. Although the causes of the majority of neurodegenerative diseases are still unknown, it has become increasingly clear that the major basic processes that induce neurodegeneration are multifactorial ones that are caused by genetic, endogenous, and environmental factors. Protein misfolding and aggregation, oxidative stress, mitochondrial dysfunction, and phosphorylation impairment are the major shared neurodegenerative pathogenic processes (Jellinger 2003).
Mercury Toxicity and Neurodegenerative Effects
Neurodegeneration is a broadly defined term that describes the loss of neuronal structure and function, and produces disorders known as neurodegenerative diseases. A common feature of neurodegeneration is the progressive cell loss in specific neuronal populations of the central nervous system (CNS), often associated with cytoskeletal protein changes that led to intracytoplasmic and/or intranuclear inclusions in neurons and/or glia. The neurological consequences of neurodegeneration in patients are often devastating and result in severe mental and physical effects, accounting for a large number of hospitalizations and disabilities. Although the causes of the majority of neurodegenerative diseases are still unknown, it has become increasingly clear that the major basic processes that induce neurodegeneration are multifactorial ones that are caused by genetic, endogenous, and environmental factors. Protein misfolding and aggregation, oxidative stress, mitochondrial dysfunction, and phosphorylation impairment are the major shared neurodegenerative pathogenic processes (Jellinger 2003).
Mercury Toxicity and Neurodegenerative Effects
Reviews Env.Contamination(formerly:Residue Reviews)
Whitacre, David M. (Herausgeber:in) / Carocci, Alessia (Autor:in) / Rovito, Nicola (Autor:in) / Sinicropi, Maria Stefania (Autor:in) / Genchi, Giuseppe (Autor:in)
Reviews of Environmental Contamination and Toxicology ; Kapitel: 1 ; 229 ; 1-18
31.12.2013
18 pages
Aufsatz/Kapitel (Buch)
Elektronische Ressource
Englisch
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