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Investigation on the interaction between Ag+ and bovine hemoglobin using spectroscopic methods
Silver ions (Ag+) can be released by silver nanoparticles (AgNPs) which are widely used in diverse fields. Ag+ can exist inside cells to produce cytotoxicity. This report uses spectroscopic methods to reveal the interactions between Ag+ and bovine hemoglobin (BHb). The results of the quenching rate constant (K q) and the fluorescence lifetime detection showed that the quenching mechanism of BHb by Ag+ was static. Thermodynamic investigations indicated that Ag+ can interact with BHb with one binding site to form complex mainly through van der Waals interactions and hydrogen bonds. The UV-vis absorption and synchronous fluorescence spectra showed that Ag+ changed the conformation of BHb, which may affect protein functions. This research is favorable for understanding the molecular toxic mechanism of Ag+ in vivo.
Investigation on the interaction between Ag+ and bovine hemoglobin using spectroscopic methods
Silver ions (Ag+) can be released by silver nanoparticles (AgNPs) which are widely used in diverse fields. Ag+ can exist inside cells to produce cytotoxicity. This report uses spectroscopic methods to reveal the interactions between Ag+ and bovine hemoglobin (BHb). The results of the quenching rate constant (K q) and the fluorescence lifetime detection showed that the quenching mechanism of BHb by Ag+ was static. Thermodynamic investigations indicated that Ag+ can interact with BHb with one binding site to form complex mainly through van der Waals interactions and hydrogen bonds. The UV-vis absorption and synchronous fluorescence spectra showed that Ag+ changed the conformation of BHb, which may affect protein functions. This research is favorable for understanding the molecular toxic mechanism of Ag+ in vivo.
Investigation on the interaction between Ag+ and bovine hemoglobin using spectroscopic methods
Chi, Zhenxing (Autor:in) / Weng, Ling (Autor:in) / Zhang, Xunuo (Autor:in)
Journal of Environmental Science and Health, Part A ; 56 ; 1367-1372
27.12.2021
6 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Unbekannt
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