Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Polyethylene terephthalate nanoplastics cause oxidative stress induced cell death in Saccharomyces cerevisiae
Polyethylene terephthalate (PET) is a common plastic widely used in food and beverage packaging that poses a serious risk to human health and the environment due to the continual rise in its production and usage. After being produced and used, PET accumulates in the environment and breaks down into nanoplastics (NPs), which are then consumed by humans through water and food sources. The threats to human health and the environment posed by PET-NPs are of great concern worldwide, yet little is known about their biological impacts. Herein, the smallest sized PET-NPs so far (56 nm) with an unperturbed PET structure were produced by a modified dilution-precipitation method and their potential cytotoxicity was evaluated in Saccharomyces cerevisiae. Exposure to PET-NPs decreased cell viability due to oxidative stress induction revealed by the increased expression levels of stress response related-genes as well as increased lipid peroxidation. Cell death induced by PET-NP exposure was mainly through apoptosis, while autophagy had a protective role.
Polyethylene terephthalate nanoplastics cause oxidative stress induced cell death in Saccharomyces cerevisiae
Polyethylene terephthalate (PET) is a common plastic widely used in food and beverage packaging that poses a serious risk to human health and the environment due to the continual rise in its production and usage. After being produced and used, PET accumulates in the environment and breaks down into nanoplastics (NPs), which are then consumed by humans through water and food sources. The threats to human health and the environment posed by PET-NPs are of great concern worldwide, yet little is known about their biological impacts. Herein, the smallest sized PET-NPs so far (56 nm) with an unperturbed PET structure were produced by a modified dilution-precipitation method and their potential cytotoxicity was evaluated in Saccharomyces cerevisiae. Exposure to PET-NPs decreased cell viability due to oxidative stress induction revealed by the increased expression levels of stress response related-genes as well as increased lipid peroxidation. Cell death induced by PET-NP exposure was mainly through apoptosis, while autophagy had a protective role.
Polyethylene terephthalate nanoplastics cause oxidative stress induced cell death in Saccharomyces cerevisiae
Kaluç, Nur (Autor:in) / Çötelli, E. Lal (Autor:in) / Tuncay, Salih (Autor:in) / Thomas, Pınar B. (Autor:in)
Journal of Environmental Science and Health, Part A ; 59 ; 180-188
20.03.2024
9 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Nano-ZnO Induced Flocculation of Saccharomyces cerevisiae
| British Library Conference Proceedings | 2013
Laser-induced periodic surface structure formation on polyethylene-terephthalate
| British Library Online Contents | 1998
| American Chemical Society | 2022
Thermal degradation properties of polyethylene terephthalate and polybutylene terephthalate
| British Library Online Contents | 2016