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Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis
https://orcid.org/0000-0001-7990-2856
AbstractAchieving hemostasis effectively is essential for surgical success and excellent patient outcomes. However, it is challenging to develop hemostatic adhesives that are fast‐acting, strongly adherent, long‐lasting, and biocompatible for treating hemorrhage. In this study, a sequential crosslinking fibrin glue (SCFG) is developed, of which the first network of the fibrin glue forms in situ within 2 s to act as an initial physical barrier and locks the gelatin methacryloyl precursor for tight construction of the second network to enhance wet adhesion and durability for tissues covered with blood. The sequential crosslinking glue can provide large pressures (≈280 mmHg of burst pressure), makes strong (38 kPa of shear strength) and tough (≈60 J m−2 of interfacial toughness) interfaces with wet tissues, and outperforms commercial hemostatic agents and gelatin methacryloyl. SCFG are demonstrated as an effective and safe sealant to enhance the treatment outcomes of bleeding tissues in rat, rabbit, and pig models. The ultrafast gelation, strong adhesion and durability, excellent compatibility, and easy manufacture of SCFG make it a promising hemostatic adhesive for clinical applications.
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis
https://orcid.org/0000-0001-7990-2856
AbstractAchieving hemostasis effectively is essential for surgical success and excellent patient outcomes. However, it is challenging to develop hemostatic adhesives that are fast‐acting, strongly adherent, long‐lasting, and biocompatible for treating hemorrhage. In this study, a sequential crosslinking fibrin glue (SCFG) is developed, of which the first network of the fibrin glue forms in situ within 2 s to act as an initial physical barrier and locks the gelatin methacryloyl precursor for tight construction of the second network to enhance wet adhesion and durability for tissues covered with blood. The sequential crosslinking glue can provide large pressures (≈280 mmHg of burst pressure), makes strong (38 kPa of shear strength) and tough (≈60 J m−2 of interfacial toughness) interfaces with wet tissues, and outperforms commercial hemostatic agents and gelatin methacryloyl. SCFG are demonstrated as an effective and safe sealant to enhance the treatment outcomes of bleeding tissues in rat, rabbit, and pig models. The ultrafast gelation, strong adhesion and durability, excellent compatibility, and easy manufacture of SCFG make it a promising hemostatic adhesive for clinical applications.
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis
https://orcid.org/0000-0001-7990-2856
AbstractAchieving hemostasis effectively is essential for surgical success and excellent patient outcomes. However, it is challenging to develop hemostatic adhesives that are fast‐acting, strongly adherent, long‐lasting, and biocompatible for treating hemorrhage. In this study, a sequential crosslinking fibrin glue (SCFG) is developed, of which the first network of the fibrin glue forms in situ within 2 s to act as an initial physical barrier and locks the gelatin methacryloyl precursor for tight construction of the second network to enhance wet adhesion and durability for tissues covered with blood. The sequential crosslinking glue can provide large pressures (≈280 mmHg of burst pressure), makes strong (38 kPa of shear strength) and tough (≈60 J m−2 of interfacial toughness) interfaces with wet tissues, and outperforms commercial hemostatic agents and gelatin methacryloyl. SCFG are demonstrated as an effective and safe sealant to enhance the treatment outcomes of bleeding tissues in rat, rabbit, and pig models. The ultrafast gelation, strong adhesion and durability, excellent compatibility, and easy manufacture of SCFG make it a promising hemostatic adhesive for clinical applications.
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis
Advanced Science
Yu, Lisha (Autor:in) / Liu, Zhaodi (Autor:in) / Tong, Zongrui (Autor:in) / Ding, Yihang (Autor:in) / Qian, Zhefeng (Autor:in) / Wang, Weilin (Autor:in) / Mao, Zhengwei (Autor:in) / Ding, Yuan (Autor:in)
Advanced Science ; 11
01.02.2024
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis
| Wiley | 2024
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis (Adv. Sci. 7/2024)
| Wiley | 2024
Sequential‐Crosslinking Fibrin Glue for Rapid and Reinforced Hemostasis (Adv. Sci. 7/2024)
| Wiley | 2024
| British Library Online Contents | 2003
| British Library Online Contents | 2004