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Detection of Blood Clots Using a Whole Stent as an Active Implantable Biosensor
https://orcid.org/0000-0002-5562-6479
https://orcid.org/0000-0003-4318-0382
https://orcid.org/0000-0002-3204-7511
https://orcid.org/0000-0002-4588-276X
AbstractMany cardiovascular problems stem from blockages that form within the vasculature and often treatment includes fitting a stent through percutaneous coronary intervention. This offers a minimally invasive therapy but re‐occlusion through restenosis or thrombosis formation often occurs post‐deployment. Research is ongoing into the creation of smart stents that can detect the occurrence of further problems. In this study, it is shown that selectively metalizing a non‐conductive stent can create a set of electrodes that are capable of detecting a build‐up of material around the stent. The associated increase in electrical impedance across the electrodes is measured, testing the stent with blood clot to mimic thrombosis. It is shown that the device is capable of sensing different amounts of occlusion. The stent can reproducibly sense the presence of clot showing a 16% +/−3% increase in impedance which is sufficient to reliably detect the clot when surrounded by explanted aorta (one samplet‐test,p= 0.009,n= 9). It is demonstrated that this approach can be extended beyond the 3D printed prototypes by showing that it can be applied to a commercially available stent and it is believed that it can be further utilized by other types of medical implants.
Detection of Blood Clots Using a Whole Stent as an Active Implantable Biosensor
https://orcid.org/0000-0002-5562-6479
https://orcid.org/0000-0003-4318-0382
https://orcid.org/0000-0002-3204-7511
https://orcid.org/0000-0002-4588-276X
AbstractMany cardiovascular problems stem from blockages that form within the vasculature and often treatment includes fitting a stent through percutaneous coronary intervention. This offers a minimally invasive therapy but re‐occlusion through restenosis or thrombosis formation often occurs post‐deployment. Research is ongoing into the creation of smart stents that can detect the occurrence of further problems. In this study, it is shown that selectively metalizing a non‐conductive stent can create a set of electrodes that are capable of detecting a build‐up of material around the stent. The associated increase in electrical impedance across the electrodes is measured, testing the stent with blood clot to mimic thrombosis. It is shown that the device is capable of sensing different amounts of occlusion. The stent can reproducibly sense the presence of clot showing a 16% +/−3% increase in impedance which is sufficient to reliably detect the clot when surrounded by explanted aorta (one samplet‐test,p= 0.009,n= 9). It is demonstrated that this approach can be extended beyond the 3D printed prototypes by showing that it can be applied to a commercially available stent and it is believed that it can be further utilized by other types of medical implants.
Detection of Blood Clots Using a Whole Stent as an Active Implantable Biosensor
https://orcid.org/0000-0002-5562-6479
https://orcid.org/0000-0003-4318-0382
https://orcid.org/0000-0002-3204-7511
https://orcid.org/0000-0002-4588-276X
AbstractMany cardiovascular problems stem from blockages that form within the vasculature and often treatment includes fitting a stent through percutaneous coronary intervention. This offers a minimally invasive therapy but re‐occlusion through restenosis or thrombosis formation often occurs post‐deployment. Research is ongoing into the creation of smart stents that can detect the occurrence of further problems. In this study, it is shown that selectively metalizing a non‐conductive stent can create a set of electrodes that are capable of detecting a build‐up of material around the stent. The associated increase in electrical impedance across the electrodes is measured, testing the stent with blood clot to mimic thrombosis. It is shown that the device is capable of sensing different amounts of occlusion. The stent can reproducibly sense the presence of clot showing a 16% +/−3% increase in impedance which is sufficient to reliably detect the clot when surrounded by explanted aorta (one samplet‐test,p= 0.009,n= 9). It is demonstrated that this approach can be extended beyond the 3D printed prototypes by showing that it can be applied to a commercially available stent and it is believed that it can be further utilized by other types of medical implants.
Detection of Blood Clots Using a Whole Stent as an Active Implantable Biosensor
Advanced Science
Kirimi, Mahmut Talha (Autor:in) / Hoare, Daniel (Autor:in) / Holsgrove, Michael (Autor:in) / Czyzewski, Jakup (Autor:in) / Mirzai, Nosrat (Autor:in) / Mercer, John R. (Autor:in) / Neale, Steve L. (Autor:in)
Advanced Science ; 11
01.06.2024
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Detection of Blood Clots Using a Whole Stent as an Active Implantable Biosensor (Adv. Sci. 21/2024)
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