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Cerebral Malaria and Neuronal Implications ofPlasmodium FalciparumInfection: From Mechanisms to Advanced Models
https://orcid.org/0000-0003-3358-4789
https://orcid.org/0000-0001-7489-9782
https://orcid.org/0000-0002-5683-1706
AbstractReorganization of host red blood cells by the malaria parasitePlasmodium falciparumenables their sequestration via attachment to the microvasculature. This artificially increases the dwelling time of the infected red blood cells within inner organs such as the brain, which can lead to cerebral malaria. Cerebral malaria is the deadliest complication patients infected withP. falciparumcan experience and still remains a major public health concern despite effective antimalarial therapies. Here, the current understanding of the effect ofP. falciparumcytoadherence and their secreted proteins on structural features of the human blood‐brain barrier and their involvement in the pathogenesis of cerebral malaria are highlighted. Advanced 2D and 3D in vitro models are further assessed to study this devastating interaction between parasite and host. A better understanding of the molecular mechanisms leading to neuronal and cognitive deficits in cerebral malaria will be pivotal in devising new strategies to treat and prevent blood‐brain barrier dysfunction and subsequent neurological damage in patients with cerebral malaria.
Cerebral Malaria and Neuronal Implications ofPlasmodium FalciparumInfection: From Mechanisms to Advanced Models
https://orcid.org/0000-0003-3358-4789
https://orcid.org/0000-0001-7489-9782
https://orcid.org/0000-0002-5683-1706
AbstractReorganization of host red blood cells by the malaria parasitePlasmodium falciparumenables their sequestration via attachment to the microvasculature. This artificially increases the dwelling time of the infected red blood cells within inner organs such as the brain, which can lead to cerebral malaria. Cerebral malaria is the deadliest complication patients infected withP. falciparumcan experience and still remains a major public health concern despite effective antimalarial therapies. Here, the current understanding of the effect ofP. falciparumcytoadherence and their secreted proteins on structural features of the human blood‐brain barrier and their involvement in the pathogenesis of cerebral malaria are highlighted. Advanced 2D and 3D in vitro models are further assessed to study this devastating interaction between parasite and host. A better understanding of the molecular mechanisms leading to neuronal and cognitive deficits in cerebral malaria will be pivotal in devising new strategies to treat and prevent blood‐brain barrier dysfunction and subsequent neurological damage in patients with cerebral malaria.
Cerebral Malaria and Neuronal Implications ofPlasmodium FalciparumInfection: From Mechanisms to Advanced Models
https://orcid.org/0000-0003-3358-4789
https://orcid.org/0000-0001-7489-9782
https://orcid.org/0000-0002-5683-1706
AbstractReorganization of host red blood cells by the malaria parasitePlasmodium falciparumenables their sequestration via attachment to the microvasculature. This artificially increases the dwelling time of the infected red blood cells within inner organs such as the brain, which can lead to cerebral malaria. Cerebral malaria is the deadliest complication patients infected withP. falciparumcan experience and still remains a major public health concern despite effective antimalarial therapies. Here, the current understanding of the effect ofP. falciparumcytoadherence and their secreted proteins on structural features of the human blood‐brain barrier and their involvement in the pathogenesis of cerebral malaria are highlighted. Advanced 2D and 3D in vitro models are further assessed to study this devastating interaction between parasite and host. A better understanding of the molecular mechanisms leading to neuronal and cognitive deficits in cerebral malaria will be pivotal in devising new strategies to treat and prevent blood‐brain barrier dysfunction and subsequent neurological damage in patients with cerebral malaria.
Cerebral Malaria and Neuronal Implications ofPlasmodium FalciparumInfection: From Mechanisms to Advanced Models
Advanced Science
Akide Ndunge, Oscar Bate (Autor:in) / Kilian, Nicole (Autor:in) / Salman, Mootaz M. (Autor:in)
Advanced Science ; 9
01.12.2022
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
| Wiley | 2022
| Online Contents | 2013
Malaria, metabolism and mathematical models
| British Library Online Contents | 2017