Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics
https://orcid.org/0000-0002-8206-3325
AbstractPiezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, piezocatalytic therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of the tumor microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS2) nanoflowers are strategically designed, which exhibit enhanced piezoelectric effects. Specifically, the introduction of Co single atom not only induces lattice distortion and out‐of‐plane polarization but also leads to the formation of numerous sulfur vacancies. These changes collectively narrow the intrinsic bandgap of the material, facilitating effective separation and migration of charge carriers, and enabling efficient production of reactive oxygen species under ultrasound stimulation. Additionally, the SA‐Co@MoS2 nanoflowers demonstrate improved enzymatic activity and exhibit glutathione depletion capabilities attributed to the mixed valence states of Co, intensifying oxidative stress in tumor cells, and leading to cell cycle arrest and apoptosis, while the inactivation of glutathione peroxidase 4 induces ferroptosis. Both in vitro and in vivo results indicate that SA‐Co@MoS2 nanoflowers can significantly eliminate tumor cells. This study offers valuable insights into the exploration of single‐atom doping‐enhanced piezoelectric sonosensitizers for cancer treatment, potentially paving the way for advancements in the field of piezocatalytic synergistic enzyodynamic therapy.
Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics
https://orcid.org/0000-0002-8206-3325
AbstractPiezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, piezocatalytic therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of the tumor microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS2) nanoflowers are strategically designed, which exhibit enhanced piezoelectric effects. Specifically, the introduction of Co single atom not only induces lattice distortion and out‐of‐plane polarization but also leads to the formation of numerous sulfur vacancies. These changes collectively narrow the intrinsic bandgap of the material, facilitating effective separation and migration of charge carriers, and enabling efficient production of reactive oxygen species under ultrasound stimulation. Additionally, the SA‐Co@MoS2 nanoflowers demonstrate improved enzymatic activity and exhibit glutathione depletion capabilities attributed to the mixed valence states of Co, intensifying oxidative stress in tumor cells, and leading to cell cycle arrest and apoptosis, while the inactivation of glutathione peroxidase 4 induces ferroptosis. Both in vitro and in vivo results indicate that SA‐Co@MoS2 nanoflowers can significantly eliminate tumor cells. This study offers valuable insights into the exploration of single‐atom doping‐enhanced piezoelectric sonosensitizers for cancer treatment, potentially paving the way for advancements in the field of piezocatalytic synergistic enzyodynamic therapy.
Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics
https://orcid.org/0000-0002-8206-3325
AbstractPiezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, piezocatalytic therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of the tumor microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS2) nanoflowers are strategically designed, which exhibit enhanced piezoelectric effects. Specifically, the introduction of Co single atom not only induces lattice distortion and out‐of‐plane polarization but also leads to the formation of numerous sulfur vacancies. These changes collectively narrow the intrinsic bandgap of the material, facilitating effective separation and migration of charge carriers, and enabling efficient production of reactive oxygen species under ultrasound stimulation. Additionally, the SA‐Co@MoS2 nanoflowers demonstrate improved enzymatic activity and exhibit glutathione depletion capabilities attributed to the mixed valence states of Co, intensifying oxidative stress in tumor cells, and leading to cell cycle arrest and apoptosis, while the inactivation of glutathione peroxidase 4 induces ferroptosis. Both in vitro and in vivo results indicate that SA‐Co@MoS2 nanoflowers can significantly eliminate tumor cells. This study offers valuable insights into the exploration of single‐atom doping‐enhanced piezoelectric sonosensitizers for cancer treatment, potentially paving the way for advancements in the field of piezocatalytic synergistic enzyodynamic therapy.
Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics
Advanced Science
Bai, Haomiao (Autor:in) / Ding, Sujun (Autor:in) / Dai, Yanfei (Autor:in) / Liu, Jiefu (Autor:in) / Chen, Huangjing (Autor:in) / Feng, Wei (Autor:in) / Yu, Dehong (Autor:in) / Chen, Yu (Autor:in) / Ni, Xuejun (Autor:in)
14.02.2025
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Preparation and characterization of polythiophene/molybdenum disulfide intercalation material
| British Library Online Contents | 2009
| British Library Online Contents | 2004
Cobalt-doped disulfide nanotubes prepared by exfoliation–intercalation–hydrothermal adulteration
| British Library Online Contents | 2006
Novel intercalation compound of poly[oligo(ethylene glycol)-oxalate] in molybdenum disulfide
| British Library Online Contents | 2003
| British Library Online Contents | 2003