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Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response
https://orcid.org/0009-0003-0772-1062
https://orcid.org/0009-0006-7727-8088
https://orcid.org/0000-0001-6495-2594
https://orcid.org/0000-0003-0272-1576
https://orcid.org/0000-0003-0060-0535
AbstractNeuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti‐inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐reader YTH domain‐containing family protein 2 (YTHDF2). This modulation affects the expression of critical genes, resulting in reduced inflammatory responses. These findings highlight the importance of post‐transcriptional modifications of RNA in the neuroprotective and anti‐inflammatory effects of curcumin, offering new insights for the treatment of related diseases.
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response
https://orcid.org/0009-0003-0772-1062
https://orcid.org/0009-0006-7727-8088
https://orcid.org/0000-0001-6495-2594
https://orcid.org/0000-0003-0272-1576
https://orcid.org/0000-0003-0060-0535
AbstractNeuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti‐inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐reader YTH domain‐containing family protein 2 (YTHDF2). This modulation affects the expression of critical genes, resulting in reduced inflammatory responses. These findings highlight the importance of post‐transcriptional modifications of RNA in the neuroprotective and anti‐inflammatory effects of curcumin, offering new insights for the treatment of related diseases.
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response
https://orcid.org/0009-0003-0772-1062
https://orcid.org/0009-0006-7727-8088
https://orcid.org/0000-0001-6495-2594
https://orcid.org/0000-0003-0272-1576
https://orcid.org/0000-0003-0060-0535
AbstractNeuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti‐inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐reader YTH domain‐containing family protein 2 (YTHDF2). This modulation affects the expression of critical genes, resulting in reduced inflammatory responses. These findings highlight the importance of post‐transcriptional modifications of RNA in the neuroprotective and anti‐inflammatory effects of curcumin, offering new insights for the treatment of related diseases.
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response
Advanced Science
Zhang, Ninan (Autor:in) / Lin, Ruifan (Autor:in) / Gao, Wenya (Autor:in) / Xu, Honglin (Autor:in) / Li, Yuejia (Autor:in) / Huang, Xiahe (Autor:in) / Wang, Yingchun (Autor:in) / Jing, Xianghong (Autor:in) / Meng, Wenxiang (Autor:in) / Xie, Qi (Autor:in)
08.02.2025
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
| British Library Online Contents | 2010