Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening
https://orcid.org/0000-0001-5763-7553
AbstractIn vitro models are crucial in cancer research, but they must truthfully mimic in vivo tumors for clinical relevance. The development of unprecedent melanoma quadruple multicellular tumoroids (MCTs) is proposed comprising tumor cells, keratinocytes, fibroblasts, and monocytes that replicate tumor architecture, tumor microenvironment, and secretome behavior. These MCTs of 300 µm in diameter secreted keratin and collagen, showing complexity proportional to their cell combinations. Further, closely resembled in vivo tumors in terms of cells organization, growth, progression, and immune behavior. Drug screening using these MCTs demonstrated their potential as patient‐derived platforms for precision medicine. These findings highlight the true value of MCTs for studying melanoma biology and testing therapeutic interventions with greater precision and relevance to human disease.
Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening
https://orcid.org/0000-0001-5763-7553
AbstractIn vitro models are crucial in cancer research, but they must truthfully mimic in vivo tumors for clinical relevance. The development of unprecedent melanoma quadruple multicellular tumoroids (MCTs) is proposed comprising tumor cells, keratinocytes, fibroblasts, and monocytes that replicate tumor architecture, tumor microenvironment, and secretome behavior. These MCTs of 300 µm in diameter secreted keratin and collagen, showing complexity proportional to their cell combinations. Further, closely resembled in vivo tumors in terms of cells organization, growth, progression, and immune behavior. Drug screening using these MCTs demonstrated their potential as patient‐derived platforms for precision medicine. These findings highlight the true value of MCTs for studying melanoma biology and testing therapeutic interventions with greater precision and relevance to human disease.
Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening
https://orcid.org/0000-0001-5763-7553
AbstractIn vitro models are crucial in cancer research, but they must truthfully mimic in vivo tumors for clinical relevance. The development of unprecedent melanoma quadruple multicellular tumoroids (MCTs) is proposed comprising tumor cells, keratinocytes, fibroblasts, and monocytes that replicate tumor architecture, tumor microenvironment, and secretome behavior. These MCTs of 300 µm in diameter secreted keratin and collagen, showing complexity proportional to their cell combinations. Further, closely resembled in vivo tumors in terms of cells organization, growth, progression, and immune behavior. Drug screening using these MCTs demonstrated their potential as patient‐derived platforms for precision medicine. These findings highlight the true value of MCTs for studying melanoma biology and testing therapeutic interventions with greater precision and relevance to human disease.
Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening
Advanced Science
Viegas, Juliana (Autor:in) / Costa, Sofia (Autor:in) / Dias, Sofia (Autor:in) / Pereira, Catarina Leite (Autor:in) / Sarmento, Bruno (Autor:in)
Advanced Science ; 11
01.12.2024
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
Patient‐Derived Melanoma Immune‐Tumoroids as a Platform for Precise High throughput Drug Screening
| Wiley | 2024
High-throughput screening platform for CRISPR
| British Library Online Contents | 2016
High-throughput screening platform for CRISPR
| British Library Online Contents | 2016
Patient‐Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening
| Wiley | 2022