Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
Eine Plattform für die Wissenschaft: Bauingenieurwesen, Architektur und Urbanistik
MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM17
The stemness of lung cancer cells contributes to drug resistance, tumor occurrence, progression, and recurrence; however, the underlying mechanisms are still fragmentary. In the present study, it was found that exosomes from cisplatin‐resistant cells and spheres derived from lung cancer cells enhanced the stemness of the parental lung cancer cells. Then we screened the upregulated miRNAs in spheres derived from lung cancer cells and cisplatin‐resistant lung cancer cells/exosomes compared to that in the parental lung cancer cells. It was found that miR‐1246 was remarkably enriched in cisplatin‐resistant lung cancer cells/exosomes and spheres. Additionally, inhibition of miR‐1246 attenuated the stemness of lung cancer cells induced by exosomes from cisplatin‐resistant cells and spheres. Furthermore, TRIM17 was identified to the direct target of miR‐1246 in lung cancer cells. Our findings suggest that exosomal miR‐1246 could be as a potential target for lung cancer treatment.
MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM17
The stemness of lung cancer cells contributes to drug resistance, tumor occurrence, progression, and recurrence; however, the underlying mechanisms are still fragmentary. In the present study, it was found that exosomes from cisplatin‐resistant cells and spheres derived from lung cancer cells enhanced the stemness of the parental lung cancer cells. Then we screened the upregulated miRNAs in spheres derived from lung cancer cells and cisplatin‐resistant lung cancer cells/exosomes compared to that in the parental lung cancer cells. It was found that miR‐1246 was remarkably enriched in cisplatin‐resistant lung cancer cells/exosomes and spheres. Additionally, inhibition of miR‐1246 attenuated the stemness of lung cancer cells induced by exosomes from cisplatin‐resistant cells and spheres. Furthermore, TRIM17 was identified to the direct target of miR‐1246 in lung cancer cells. Our findings suggest that exosomal miR‐1246 could be as a potential target for lung cancer treatment.
MiR‐1246 is responsible for lung cancer cells‐derived exosomes‐mediated promoting effects on lung cancer stemness via targeting TRIM17
Liu, Zhengcheng (Autor:in) / Zhao, Wei (Autor:in) / Yang, Rusong (Autor:in)
Environmental Toxicology ; 37 ; 2651-2659
01.11.2022
9 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
cancer stem cell , exosome , MiR‐1246 , stemness , TRIM17