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Photocatalytic Quantum Dot‐Armed Bacteriophage for Combating Drug‐Resistant Bacterial Infection
Multidrug‐resistant (MDR) bacterial infection is one of the greatest challenges to public health, a crisis demanding the next generation of highly effective antibacterial agents to specifically target MDR bacteria. Herein, a novel photocatalytic quantum dot (QD)‐armed bacteriophage (QD@Phage) is reported for combating green fluorescent protein‐expressing Pseudomonas aeruginosa (GFP‐P. aeruginosa) infection. The proposed QD@Phage nanosystem not only specifically binds to the host GFP‐P. aeruginosa while preserving the infectivity of the phage itself, but also shows a superior capacity for synergistic bacterial killing by phage and by the photocatalytic localized reactive oxygen species (ROS) generated from anchored QD components. Notably, this highly targeted QD@Phage nanosystem achieves robust in vitro antibacterial elimination for both planktonic (over 99.9%) and biofilm (over 99%) modes of growth. In a mouse wound infection model, this system also shows remarkable activity in eliminating the wound infection and promoting its recovery. These results demonstrate that the novel QD@Phage nanosystem can diversify the existing pool of antibacterial agents and inspire the development of promising therapeutic strategies against MDR bacterial infection.
Photocatalytic Quantum Dot‐Armed Bacteriophage for Combating Drug‐Resistant Bacterial Infection
Multidrug‐resistant (MDR) bacterial infection is one of the greatest challenges to public health, a crisis demanding the next generation of highly effective antibacterial agents to specifically target MDR bacteria. Herein, a novel photocatalytic quantum dot (QD)‐armed bacteriophage (QD@Phage) is reported for combating green fluorescent protein‐expressing Pseudomonas aeruginosa (GFP‐P. aeruginosa) infection. The proposed QD@Phage nanosystem not only specifically binds to the host GFP‐P. aeruginosa while preserving the infectivity of the phage itself, but also shows a superior capacity for synergistic bacterial killing by phage and by the photocatalytic localized reactive oxygen species (ROS) generated from anchored QD components. Notably, this highly targeted QD@Phage nanosystem achieves robust in vitro antibacterial elimination for both planktonic (over 99.9%) and biofilm (over 99%) modes of growth. In a mouse wound infection model, this system also shows remarkable activity in eliminating the wound infection and promoting its recovery. These results demonstrate that the novel QD@Phage nanosystem can diversify the existing pool of antibacterial agents and inspire the development of promising therapeutic strategies against MDR bacterial infection.
Photocatalytic Quantum Dot‐Armed Bacteriophage for Combating Drug‐Resistant Bacterial Infection
Wang, Lei (Autor:in) / Fan, Xin (Autor:in) / Gonzalez Moreno, Mercedes (Autor:in) / Tkhilaishvili, Tamta (Autor:in) / Du, Weijie (Autor:in) / Zhang, Xianlong (Autor:in) / Nie, Chuanxiong (Autor:in) / Trampuz, Andrej (Autor:in) / Haag, Rainer (Autor:in)
Advanced Science ; 9
01.06.2022
8 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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