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Stimulation and Repair of Peripheral Nerves Using Bioadhesive Graft‐Antenna
An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft‐antenna). The graft‐antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft‐antenna and stimulated by the TMS for 1 h per week. The graft‐antenna is an innovative and minimally‐invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.
Stimulation and Repair of Peripheral Nerves Using Bioadhesive Graft‐Antenna
An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft‐antenna). The graft‐antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft‐antenna and stimulated by the TMS for 1 h per week. The graft‐antenna is an innovative and minimally‐invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.
Stimulation and Repair of Peripheral Nerves Using Bioadhesive Graft‐Antenna
Sliow, Ashour (Autor:in) / Ma, Zhi (Autor:in) / Gargiulo, Gaetano (Autor:in) / Mahns, David (Autor:in) / Mawad, Damia (Autor:in) / Breen, Paul (Autor:in) / Stoodley, Marcus (Autor:in) / Houang, Jessica (Autor:in) / Kuchel, Rhiannon (Autor:in) / Tettamanzi, Giuseppe C. (Autor:in)
Advanced Science ; 6
01.06.2019
13 pages
Aufsatz (Zeitschrift)
Elektronische Ressource
Englisch
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